Results 31 to 40 of about 24,357,552 (149)

Flurbiprofen-Loaded Solid SNEDDS Preconcentrate for the Enhanced Solubility, In-Vitro Dissolution and Bioavailability in Rats

Pharmaceutics, 2018
The aim of this work was to prepare and optimize a solid self-nanoemulsifying drug delivery system pre-concentrate (SSP) containing water-insoluble flurbiprofen (FL) using a novel pseudo-ternary phase diagram.
Rae Man Kim, Dong-Jin Jang, Yu Chul Kim, Jin-Ha Yoon, Kyoung Ah Min, Han-Joo Maeng, Kwan Hyung Cho   +6 more
doaj   +1 more source

Oral solid self-nanoemulsifying drug delivery systems of candesartan citexetil: formulation, characterization and in vitro drug release studies

AAPS Open, 2017
Candesartan cilexetil is an ester prodrug antagonist to angiotensin II receptor type 1 (AT1) used in management of many cardiovascular diseases. The absolute bioavailability of candesartan cilexetil is about (14–40%).
Halah Hussein Ali, Ahmed Abbas Hussein
doaj   +1 more source

Solid Lipid Nanoparticles: A Potential Approach for Dermal Drug Delivery [PDF]

, 2014
Solid lipid nanoparticles (SLNs) have attracted increasing attention during recent years. Due to their unique size dependent properties, lipid nanoparticles offer possibilities to develop new therapeutics.
Conway, Barbara R, Kakadia, Pratibha G., Conway, Barbara, Kakadia, Partibha   +3 more
core   +1 more source

Self nano-emulsifying drug delivery system for Embelin: Design, characterization and in-vitro studies

Asian Journal of Pharmaceutical Sciences, 2015
CThe objective of the present study was to prepare solid self-nanoemulsifying drug delivery system (S-SNEDDS) containing Capryol-90 as oil phase for the delivery of Embelin, a poorly water soluble herbal active ingredient. Box-Behnken experimental design
Komal Parmar, Jayvadan Patel, Navin Sheth   +2 more
doaj   +1 more source

Solid Self-Nano Emulsifying Nanoplatform Loaded with Tamoxifen and Resveratrol for Treatment of Breast Cancer

Pharmaceutics, 2022
The solid self-nanoemulsifying drug delivery system (s-SNEDDS) is a growing platform for the delivery of drugs via oral route. In the present work, tamoxifen (TAM) was loaded in SNEDDS with resveratrol (RES), which is a potent chemotherapeutic ...
Nupur Shrivastava, Ankit Parikh, Rikeshwer Prasad Dewangan, Largee Biswas, Anita Kamra Verma, Saurabh Mittal, Javed Ali, Sanjay Garg, Sanjula Baboota   +8 more
doaj   +1 more source

A Solid Ultra Fine Self-Nanoemulsifying Drug Delivery System (S-SNEDDS) of Deferasirox for Improved Solubility: Optimization, Characterization, and In Vitro Cytotoxicity Studies

Pharmaceuticals, 2020
The research work was designed to develop a solid self-nanoemulsifying drug delivery system (S-SNEDDS) of deferasirox (DFX). According to the solubility studies of DFX in different components, Peceol, Kolliphor EL, and Transcutol were selected as ...
Alaa Alghananim, Yıldız Özalp, Burcu Mesut, Nedime Serakinci, Yıldız Özsoy, Sevgi Güngör   +5 more
doaj   +1 more source

Formulation and Evaluation of Self-Nanoemulsifying Drug Delivery System Derived Tablet Containing Sertraline

Pharmaceutics, 2022
Being a biopharmaceutics classification system class II drug, the absorption of sertraline from the gut is mainly limited by its poor aqueous solubility.
Anroop B. Nair, Bhavna Singh, Jigar Shah, Shery Jacob, Bandar Aldhubiab, Nagaraja Sreeharsha, Mohamed A. Morsy, Katharigatta N. Venugopala, Mahesh Attimarad, Pottathil Shinu   +9 more
doaj   +1 more source

Self-Nanoemulsifying Drug Delivery System for Enhanced Bioavailability of Madecassic Acid: In vitro and in vivo Evaluation

, 2023
Li Lin,1,* Qingyong Chen,1,* Yue Dai,2 Yufeng Xia1 1Department of Pharmacognosy, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, 211198, People’s Republic of China; 2Department of Traditional Chinese Medicine and
Xia Y, Chen Q, Lin L, Dai Y
core  

Unlocking the Potential: Synergistic Effects of Solid SNEDDS and Lyophilized Solid Dispersion to Enhance Stability Attributes

Frontiers in Bioscience-Landmark, 2023
Background: Among lipid-based formulations, self-nanoemulsifying drug delivery systems (SNEDDS) have captured a spotlight, captivating both academia and the pharmaceutical industry.
Ahmad Yousef Tashish, Ahmad Abdul-Wahhab Shahba, Fars Kaed Alanazi, Mohsin Kazi   +3 more
doaj   +1 more source

Combined Self-Nanoemulsifying and Solid Dispersion Systems Showed Enhanced Cinnarizine Release in Hypochlorhydria/Achlorhydria Dissolution Model

, 2021
The study aims to design a novel combination of drug-free solid self-nanoemulsifying drug delivery systems (S-SNEDDS) + solid dispersion (SD) to enhance cinnarizine (CN) dissolution at high pH environment caused by hypochlorhydria/achlorhydria.
Ahmad A. Shahba, Ahmad Y. Tashish, Fars K. Alanazi, Mohsin Kazi   +3 more
core   +1 more source