Results 231 to 240 of about 76,206 (274)
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Metabolism, 1990
Hippocampal neurons containing somatostatin have been shown to be vulnerable in some experimental models of epilepsy. In this report, we describe our recent findings about the seizure-related changes in somatostatin in brain tissue and cerebrospinal fluid (CSF) in experimental and human epilepsy.
P J, Riekkinen, A, Pitkänen
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Hippocampal neurons containing somatostatin have been shown to be vulnerable in some experimental models of epilepsy. In this report, we describe our recent findings about the seizure-related changes in somatostatin in brain tissue and cerebrospinal fluid (CSF) in experimental and human epilepsy.
P J, Riekkinen, A, Pitkänen
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Somatostatin analogues: Are they analogues of somatostatin?
Journal of Endocrinological Investigation, 2002Dear Sir, Somatostatin (SRIH) was discovered because of its surprising inhibitory effect on GH secretion (1), and thus appropriately named. Later on, its ubiquitousness and the inhibiting activity on pancreatic hormones and on other types of hormones, rendered its name too restrictive. It was by then too late to change it.
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Trends in Endocrinology and Metabolism, 1985
It is now well established that the biological actions of tetradecapeptide somatostatin (somatostatin-14, S-14) are receptor-mediated. These receptors were first quantified in GH4C pituitary tumor cells using [125I-Tyr1] S-14 as radioligand which was found to exhibit high non-specific binding to membrane receptor preparations from normal tissues.
Y C, Patel, C B, Srikant
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It is now well established that the biological actions of tetradecapeptide somatostatin (somatostatin-14, S-14) are receptor-mediated. These receptors were first quantified in GH4C pituitary tumor cells using [125I-Tyr1] S-14 as radioligand which was found to exhibit high non-specific binding to membrane receptor preparations from normal tissues.
Y C, Patel, C B, Srikant
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Lung Cancer, 1993
Lung carcinoma is the most common cause of death in the western world and is increasing particularly among women. Despite significant developments in our understanding of the molecular biology of this disease our ability to treat the various subtypes of lung cancer has been at a relative standstill for the past decade.
K J, O'Byrne, D N, Carney
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Lung carcinoma is the most common cause of death in the western world and is increasing particularly among women. Despite significant developments in our understanding of the molecular biology of this disease our ability to treat the various subtypes of lung cancer has been at a relative standstill for the past decade.
K J, O'Byrne, D N, Carney
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The Journal of Peptide Research, 2001
Abstract: Somatostatin is a hypothalamic peptide hormone that inhibits the secretion of growth hormone, glucagon, insulin, gastrin and secretin, and also plays a role in neural transmission. Because of its wide range of possible clinical applications hundreds of somatostatin analogs have been synthesized and bioassayed to date.
A, Janecka, M, Zubrzycka, T, Janecki
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Abstract: Somatostatin is a hypothalamic peptide hormone that inhibits the secretion of growth hormone, glucagon, insulin, gastrin and secretin, and also plays a role in neural transmission. Because of its wide range of possible clinical applications hundreds of somatostatin analogs have been synthesized and bioassayed to date.
A, Janecka, M, Zubrzycka, T, Janecki
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1985
This is a review of pancreatic somatostatin which is limited in its scope and therefore focuses upon some selected issues. Throughout the entire review the same basic questions recur: Why do islets contain somatostatin? What is the physiological role of somatostatin and what does this peptide have to do with diabetes?
G C, Weir, S, Bonner-Weir
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This is a review of pancreatic somatostatin which is limited in its scope and therefore focuses upon some selected issues. Throughout the entire review the same basic questions recur: Why do islets contain somatostatin? What is the physiological role of somatostatin and what does this peptide have to do with diabetes?
G C, Weir, S, Bonner-Weir
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[Somatostatin and somatostatin receptors in the prostate].
Minerva endocrinologica, 2001Somatostatin (st) exerts a role in the control of prostate growth and function acting both at hypothalamus-hypophysis level and at glandular level. St analogues have been used to control prostate cancer (CaP) in clinical trials, with contradictory results.
SINISI, Antonio Agostino +2 more
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Journal of Endocrinological Investigation, 2003
We discuss the recent knowledge concerning domatostatin action in follicular and parafollicular cell function regulation.
ZATELLI, Maria Chiara +2 more
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We discuss the recent knowledge concerning domatostatin action in follicular and parafollicular cell function regulation.
ZATELLI, Maria Chiara +2 more
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Hormone Research, 2008
Biological activity of somatostatin can be altered by modiñcations in the amino acid sequence. Thus, a number of bioassays have been developed in order to measure the potency and specificity of analogues and heterogenous molecular forms of somatostatin.
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Biological activity of somatostatin can be altered by modiñcations in the amino acid sequence. Thus, a number of bioassays have been developed in order to measure the potency and specificity of analogues and heterogenous molecular forms of somatostatin.
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Medical Clinics of North America, 1978
Somatostatin may act as a local regulator of endocrine and exocrine secretion and as a peptidergic neurotransmitter rather than as a classical circulating hormone. The possible physiologic role of its secretion in the regulation of islet A and B cell function, and particularly its significance in nutrient homeostasis and diabetes, are discussed.
R A, Rizza, J E, Gerich
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Somatostatin may act as a local regulator of endocrine and exocrine secretion and as a peptidergic neurotransmitter rather than as a classical circulating hormone. The possible physiologic role of its secretion in the regulation of islet A and B cell function, and particularly its significance in nutrient homeostasis and diabetes, are discussed.
R A, Rizza, J E, Gerich
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