Results 221 to 230 of about 76,206 (274)

Somatostatin and Somatostatin Receptors

2009
The biological effects of somatostatin (SST) were first encountered unexpectedly in the late 1960s in two unrelated studies, one by Krulich et al. (1968) who reported on a growth hormone (GH)-releasing inhibitory substance from hypothalamic extracts, and the other, by Hellman and Lernmark (1969), on the presence of a potent insulin inhibitory factor ...
Ujendra, Kumar, Michael, Grant
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Somatostatin and somatostatin analogues in oncology

Cancer Treatment Reviews, 1989
La somatostatine, et ses analogues, sa structure, sa pharmacologie, son effet antiproliferatif, et son activite anticancereux sont ...
H, Parmar, A, Bogden, M, Mollard, B, de Rougé, R H, Phillips, S L, Lightman   +5 more
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Evolutionary history of the somatostatin and somatostatin receptors

Journal of Genetics, 2009
Somatostatin and its receptors have a critical role in mammalian growth through their control pattern of secretion of growth hormone, but the evolutionary history of somatostatin and somatostatin receptors are ill defined. We used comparative whole genome analysis of Danio rerio, Carassius auratus, Xenopus tropicalis, Gallus gallus, Monodelphis ...
Muhammad, Moaeen-ud-Din, Li Guo, Yang
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Somatostatin Analogs Inhibit Somatostatin Release*

Endocrinology, 1979
To determine if, like insulin, somatostatin inhibits its own secretion from the pancreas, nonimmunoreactive analogs of somatostatin were perfused in an isolated dog pancreaticoduodenal preparation using a nonrecirculating system. [D-Trp8-D-Cys14]somatostatin, at a concentration of 200 ng/ml, blocked the response of somatostatin-like immunoreactivity ...
E, Ipp, J, Rivier, R E, Dobbs, M, Brown, W, Vale, R H, Unger   +5 more
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Somatostatin and somatostatin receptors in fish growth

General and Comparative Endocrinology, 2010
Multiple forms of somatostatin (SS) and SS receptors (SSTR) are produced widely in the tissues of fish and interact to coordinate numerous physiological processes. Insight into their role in growth regulation emerged from studies of abnormal growth and of whole animals.
Mark A, Sheridan, Alison L, Hagemeister
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Somatostatin, Somatostatin Receptors, and Pancreatic Cancer

World Journal of Surgery, 2005
AbstractSomatostatin may play an important role in the regulation of cancer growth including pancreatic cancer by interaction with somatostatin receptors (SSTRs) on the cell surface. Five SSTRs were cloned, and the function of these SSTRs is addressed in this review.
Min, Li, William E, Fisher, Hee Joon, Kim, Xiaoping, Wang, Charles F, Brunicardi, Changyi, Chen, Qizhi, Yao   +6 more
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Somatostatin

Cellular and Molecular Neurobiology, 1995
1. Somatostatin (SRIF) exerts diverse physiological actions in the body including regulation of hormone and neurotransmitter release and neuronal firing activity. Analogs of SRIF are used clinically to treat tumors and cancers and to block the hypersecretion of growth hormone in acromegaly. 2.
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Somatostatin, Somatostatin Analogs and Somatostatin Receptor Dynamics in the Biology of Cancer Progression

Current Molecular Medicine, 2013
The pharmacological effects (i.e., inhibition of endocrine secretion and cell proliferation) mediated by the hormone somatostatin (SRIF) are derived from its universal high-affinity binding to five different G proteincoupled receptors (GPCRs), named sst1-5.
Ruscica M, ARVIGO, MARICA, Steffani L, FERONE, DIEGO, Magni P.   +4 more
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Somatostatin Receptors

Digestion, 2000
Somatostatin is a neuropeptide produced by neuroendocrine, inflammatory and immune cells in response to different stimuli. Somatostatin inhibits various cellular functions including secretions, motility and proliferation. Its action is mediated by five specific somatostatin receptors (sst1-sst5) which belong to the G protein-coupled receptor family ...
N, Benali, G, Ferjoux, E, Puente, L, Buscail, C, Susini   +4 more
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Somatostatin and Somatostatin Receptor Physiology

Endocrine, 2003
Since the discovery of somatostatin (SST) over three decades ago, its ubiquitous distribution and manifold functions are still being documented. SST is synthesized in the hypothalamus and transported to the anterior pituitary gland where it tonicaly inhibits GH and TSH secretion as well as being responsible for GH pulsatile release.
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