Results 41 to 50 of about 241 (129)

Overexpression of wheat spermidine synthase gene enhances wheat resistance to Fusarium head blight

Phytopathology Research
Polyamines, such as putrescine, spermidine, and spermine, are crucial for plant defense against both abiotic and biotic stresses. Putrescine is also known as a significant inducer of deoxynivalenol (DON) production in Fusarium graminearum, the primary ...
Jingyi Ren, Chengliang Li, Qi Xiu, Ming Xu, Huiquan Liu   +4 more
doaj   +1 more source

Multi‐omics–driven precision medicine

iMeta, EarlyView.
Multi‐omics‐driven precision medicine (MODPM) provides a multiscale, continuously learnable framework that integrates genomics, epigenomics, transcriptomics, proteomics, metabolomics, microbiome profiles, and clinical data. Powered by artificial intelligence and foundation models, MODPM enables cross‐modal representation learning, contextual modeling ...
Huibo Li, Zhe Zhao, Yifan Zhang, Yao Ma, Gaofei Hu, Min Zeng, Zhanqun Yang, Zixuan Zhao, Xin Zhou, Wei Hu, Yuxuan Sun, Meng Su, Jun Li, Matthew Whiteman, Wei Fu, Chao Zhong, Lemin Zheng, Long Chen, Hairong Lv, Rongsheng Zhao, Yi Zhun Zhu   +20 more
wiley   +1 more source

Anti-inflammatory effects of spermidine in lipopolysaccharide-stimulated BV2 microglial cells

Journal of Biomedical Science, 2012
Background Spermidine, a naturally occurring polyamine, displays a wide variety of internal biological activities including cell growth and proliferation.
Choi Yung, Park Hye
doaj   +1 more source

Evaluation of differential expression of homospermidine synthase (HSS1) gene in different tissues of medicinal plant Senecio vulgaris L [PDF]

مجله بیوتکنولوژی کشاورزی, 2019
Objective Homospermidine synthase (HSS) is the first enzyme in the specific pathway of pyrrolizidiene alkaloid (PA). HSS catalyzes the NAD1-dependent transfer of an aminobutyl group of spermidine to putrescine.
Hashem Marawene, Asadollah Ahmadikhah, Masoud Tohidfar   +2 more
doaj   +1 more source

Yeast Knockout Strain Collection: Driving Functional Genomics, Biotechnological Applications and Human Disease Research

Yeast, EarlyView.
ABSTRACT The knockout strain collection of Saccharomyces cerevisiae has served as a valuable resource for functional genomics and yeast‐based biotechnology studies. A comprehensive single‐gene knockout strain collection, covering nearly all non‐essential genes, together with complementary mutant collections for essential genes, including temperature ...
Takashi Hirasawa
wiley   +1 more source

2‐Mercaptoethylamine, a competitive inhibitor of spermidine synthase in mammalian cells [PDF]

FEBS Letters, 1988
Spermidine synthase from rat ventral prostate was inhibited by 2‐mercaptoethylamine (MEA). Inhibition of spermidine synthase by MEA was competitive with respect to one of the substrates putrescine, but not competitive with respect to the other substrate decarboxylated S‐adenosylmethionine.
Hibasami, Hiroshige, Kawase, Masahiro, Tsukada, Tetsuya, Maekawa, Satoru, Sakurai, Masaki, Nakashima, Kunio   +5 more
openaire   +2 more sources

Inhibition of Ornithine Decarboxylase 1 Mitigates Denervation‐Induced Muscle Atrophy by Suppressing Proteolysis and Preserving Muscle Stem Cell Homeostasis

Cell Proliferation, EarlyView.
Polyamine metabolism is innervation responsive and involved in denervation‐induced muscle atrophy. Inhibition of polyamine metabolism attenuates muscle atrophy by restraining proteolysis and preserving MuSCs homeostasis. Denervation‐induced activation of FAP‐derived FGF7 drives premature MuSCs activation, while DFMO suppresses this paracrine cue to ...
Mingming Zhang, Feifan Chang, Siliang Ge, Fuming Cao, Pincong Fu, Haobo Zhang, Ming Chen, Yi Li, Peifu Tang, Pengbin Yin   +9 more
wiley   +1 more source

Multi-Temperature Crystallography of Polyamine Biosynthesis Enzymes Reveals Differing Active Site Conformations at RT than 100K [PDF]

Structural Dynamics
The polyamine biosynthetic pathway synthesizes the polyamines putrescine, spermidine, and spermine from ornithine and S-adenosyl methionine. These polyamines are important molecules in metabolism and are associated with growth and proliferation of cells ...
Jonathan A Clinger
doaj   +1 more source

Phenylbutyrate modulates polyamine acetylase and ameliorates Snyder-Robinson syndrome in a Drosophila model and patient cells

JCI Insight, 2022
Polyamine dysregulation plays key roles in a broad range of human diseases from cancer to neurodegeneration. Snyder-Robinson syndrome (SRS) is the first known genetic disorder of the polyamine pathway, caused by X-linked recessive loss-of-function ...
Xianzun Tao, Yi Zhu, Zoraida Diaz-Perez, Seok-Ho Yu, Jackson R. Foley, Tracy Murray Stewart, Robert A. Casero Jr., Richard Steet, R. Grace Zhai   +8 more
doaj   +1 more source

Transgenic mice over-expressing the human spermidine synthase gene [PDF]

Biochemical Journal, 1993
We have generated a transgenic mouse line harbouring the functional (chromosome-1-derived) human spermidine synthase (EC 2.5.1.16) gene in their genome. The transgenic animals expressed the human gene-derived mRNA, as revealed by reverse-transcriptase/PCR analysis, in all tissues studied and displayed tissue spermidine synthase activity that was 2-6 ...
L, Kauppinen, S, Myöhänen, M, Halmekytö, L, Alhonen, J, Jänne   +4 more
openaire   +2 more sources