Results 21 to 30 of about 241 (129)

Fluorinated analogues of spermidine as substrates of spermine synthase [PDF]

European Journal of Biochemistry, 1988
A series of mono‐and geminal difluorinated analogues of spermidine (4‐azaoctane‐1, 8‐diamine) have been tested as potential substrates of partially purified rat hepatoma (HTC) cell or pure bovine spleen spermine synthase (EC 2.5.1.22).Substitution of the hydrogen atoms of the methylene group at position 7 by one or two fluorine atoms decreases 8‐fold ...
J G, Baillon, P S, Mamont, J, Wagner, F, Gerhart, P, Lux   +4 more
openaire   +2 more sources

Crystal structure of apo human spermidine synthase reveals dynamic rearrangement at the active site [PDF]

Structural Dynamics
Polyamines are polycations involved in both differentiation and proliferation of cells. Highly conserved polyamine biosynthetic enzymes are involved in the synthesis of polyamines.
Omowumi O. Fagbohun, Molly A. Canfield, Jonathan A. Clinger   +2 more
doaj   +1 more source

Spermidine Enhances Heat Tolerance of Rice Seeds by Modulating Endogenous Starch and Polyamine Metabolism

Molecules, 2019
Polyamines have been reported to be involved in grain filling and they might contribute to the construction of heat resistance of some cereals. In this study, the hybrid rice ‘YLY 689’ was used to explore the possible effects of exogenous ...
Yuying Fu, Qingqing Gu, Qian Dong, Zhihao Zhang, Cheng Lin, Weimin Hu, Ronghui Pan, Yajing Guan, Jin Hu   +8 more
doaj   +1 more source

Macrophage ABHD5 promotes colorectal cancer growth by suppressing spermidine production by SRM

Nature Communications, 2016
ABHD5 is a co-activator of lipolysis. Here the authors show that in tumour-associated macrophages ABHD5 inhibits ROS-dependent induction of C/EBPɛ, which transcriptionally activates spermidine synthase, and that blocking ABHD5 delays colorectal cancer ...
Hongming Miao, Juanjuan Ou, Yuan Peng, Xuan Zhang, Yujuan Chen, Lijun Hao, Ganfeng Xie, Zhe Wang, Xueli Pang, Zhihua Ruan, Jianjun Li, Liqing Yu, Bingzhong Xue, Hang Shi, Chunmeng Shi, Houjie Liang   +15 more
doaj   +1 more source

Novel Synthetic Polyamines Have Potent Antimalarial Activities in vitro and in vivo by Decreasing Intracellular Spermidine and Spermine Concentrations

Frontiers in Cellular and Infection Microbiology, 2019
Twenty-two compounds belonging to several classes of polyamine analogs have been examined for their ability to inhibit the growth of the human malaria parasite Plasmodium falciparum in vitro and in vivo.
Kamal El Bissati, Henry Redel, Li-Min Ting, Joseph D. Lykins, Martin J. McPhillie, Rajendra Upadhya, Patrick M. Woster, Nigel Yarlett, Kami Kim, Kami Kim, Louis M. Weiss, Louis M. Weiss   +11 more
doaj   +1 more source

METTL3-IGF2BP3-axis mediates the proliferation and migration of pancreatic cancer by regulating spermine synthase m6A modification

Frontiers in Oncology, 2022
Spermine synthase (SMS) is an enzyme participating in polyamine synthesis; however, its function and role in pancreatic cancer remains elusive. Here we report that SMS is upregulated in pancreatic cancer and predicts a worse overall survival and ...
Zhenyun Guo, Zhenyun Guo, Xiang Zhang, Xiang Zhang, Chengjie Lin, Chengjie Lin, Yue Huang, Yue Huang, Yun Zhong, Yun Zhong, Hailing Guo, Hailing Guo, Zhou Zheng, Zhou Zheng, Shangeng Weng, Shangeng Weng, Shangeng Weng, Shangeng Weng   +17 more
doaj   +1 more source

Validation of spermidine synthase as a drug target in African trypanosomes [PDF]

Biochemical Journal, 2007
The trypanocidal activity of the ODC (ornithine decarboxylase) inhibitor DFMO (difluoromethylornithine) has validated polyamine biosynthesis as a target for chemotherapy. As DFMO is one of only two drugs used to treat patients with late-stage African trypanosomiasis, the requirement for additional drug targets is paramount.
Tayor, Martin C, Kaur, Harparkash, Blessington, Bernard, Kelly, John M, Wilkinson, Shane R   +4 more
openaire   +3 more sources

Rational engineering of homospermidine synthase for enhanced catalytic efficiency toward spermidine synthesis

Synthetic and Systems Biotechnology
Spermidine is a naturally occurring polyamine widely utilized in the prevention and treatment of various diseases. Current spermidine biosynthetic methods have problems such as low efficiency and complex multi-enzyme catalysis.
Wenjing Liu, Xiaoxiang Hu, Yi Yan, Yujie Cai   +3 more
doaj   +1 more source

Polyamine Homeostasis in Snyder-Robinson Syndrome

Medical Sciences, 2018
Loss-of-function mutations of the spermine synthase gene (SMS) result in Snyder-Robinson Syndrome (SRS), a recessive X-linked syndrome characterized by intellectual disability, osteoporosis, hypotonia, speech abnormalities, kyphoscoliosis, and seizures ...
Tracy Murray-Stewart, Matthew Dunworth, Jackson R. Foley, Charles E. Schwartz, Robert A. Casero   +4 more
doaj   +1 more source

The crystal structure of spermidine synthase with a multisubstrate adduct inhibitor [PDF]

Nature Structural Biology, 2001
Polyamines are essential in all branches of life. Spermidine synthase (putrescine aminopropyltransferase, PAPT) catalyzes the biosynthesis of spermidine, a ubiquitous polyamine. The crystal structure of the PAPT from Thermotoga maritima (TmPAPT) has been solved to 1.5 A resolution in the presence and absence of AdoDATO (S-adenosyl-1,8-diamino-3 ...
Sergey, Korolev, Yoshihiko, Ikeguchi, Tatiana, Skarina, Steven, Beasley, Cheryl, Arrowsmith, Aled, Edwards, Andrzej, Joachimiak, Anthony E, Pegg, Alexei, Savchenko   +8 more
openaire   +2 more sources