Results 1 to 10 of about 222 (110)

Structural Analysis of Spermidine Synthase from Kluyveromyces lactis

Molecules, 2023
Spermidine is a polyamine molecule that performs various cellular functions, such as DNA and RNA stabilization, autophagy modulation, and eIF5A formation, and is generated from putrescine by aminopropyltransferase spermidine synthase (SpdS).
Seongjin Kim, Jeong Ho Chang
doaj   +3 more sources

Evolution of the key alkaloid enzyme putrescine N-methyltransferase from spermidine synthase

Frontiers in Plant Science, 2013
Putrescine N-methyltransferases (PMTs) are the first specific enzymes of the biosynthesis of nicotine and tropane alkaloids. PMTs transfer a methyl group onto the diamine putrescine from S-adenosyl-L-methionine (SAM) as coenzyme.
Wolfgang Dr Brandt, Juliane Fischer
exaly   +3 more sources

Stereochemistry of spermidine synthase [PDF]

Journal of the American Chemical Society, 1982
The biosynthesis of polyamines is a topic of current interest. A number of methods for the isolation and analysis of these polyamines have been described in the literature. However, the stereochemical course of the biosynthesis of these polyamines is still undefined.\ud \ud After a general introduction to the importance of the polyamines in living ...
Bernard T. Golding, Ishaq K. Nassereddin
openaire   +2 more sources

Spermidine Synthase Localization in Retinal Layers: Early Age Changes

International Journal of Molecular Sciences
Polyamine (PA) spermidine (SPD) plays a crucial role in aging. Since SPD accumulates in glial cells, particularly in Müller retinal cells (MCs), the expression of the SPD-synthesizing enzyme spermidine synthase (SpdS) in Müller glia and age-dependent SpdS activity are not known.
Christian J Malpica Nieves, Amanda Diaz, Serguei Skatchkov   +2 more
exaly   +3 more sources

Bioengineering of Escherichia coli Nissle 1917 for Production and Excretion of Spermidine, a Key Metabolite in Human Health

Metabolites, 2022
Microbiota-derived metabolites have biological importance for their host. Spermidine, a metabolite described for its protective effect in age-related diseases, is now studied for its role in the resolution of inflammation and gut homeostasis.
Clément Caffaratti, Caroline Plazy, Valérie Cunin, Bertrand Toussaint, Audrey Le Gouellec   +4 more
doaj   +1 more source

Specificity of mammalian spermidine synthase and spermine synthase [PDF]

Biochemical Journal, 1981
1. The specificity of rat prostatic spermidine synthase and spermine synthase with respect to the amine acceptor of the propylamine group was studied. 2. Spermidine synthase could use cadaverine (1,5-diaminopentane) instead of putrescine, but the Km for cadaverine was much greater and the rate with 1mM-cadaverine was only 10% of that with putrescine. 1,
A E, Pegg, K, Shuttleworth, H, Hibasami
openaire   +2 more sources

Aminopropyltransferases involved in polyamine biosynthesis localize preferentially in the nucleus of plant cells. [PDF]

PLoS ONE, 2012
Plant aminopropyltransferases consist of a group of enzymes that transfer aminopropyl groups derived from decarboxylated S-adenosyl-methionine (dcAdoMet or dcSAM) to propylamine acceptors to produce polyamines, ubiquitous metabolites with positive charge
Borja Belda-Palazón, Leticia Ruiz, Esmeralda Martí, Susana Tárraga, Antonio F Tiburcio, Francisco Culiáñez, Rosa Farràs, Pedro Carrasco, Alejandro Ferrando   +8 more
doaj   +1 more source

Synergistic effect of carbon nanoparticles with mild salinity for improving chemical composition and antioxidant activities of radish sprouts

Frontiers in Plant Science, 2023
The demand for healthy foods with high functional value has progressively increased. Carbon nanoparticles (CNPs) have a promising application in agriculture including the enhancement of plant growth.
Riyadh F. Halawani, Hamada AbdElgawad, Fahed A. Aloufi, Mansour A. Balkhyour, Ahlem Zrig, Ahlem Zrig, Abdelrahim H.A. Hassan, Abdelrahim H.A. Hassan   +7 more
doaj   +1 more source

The Role of Spermidine and Its Key Metabolites in Important, Pathogenic Human Viruses and in Parasitic Infections Caused by Plasmodium falciparum and Trypanosoma brucei

Biomolecules, 2023
The triamine spermidine is a key metabolite of the polyamine pathway. It plays a crucial role in many infectious diseases caused by viral or parasitic infections.
Annette Kaiser
doaj   +1 more source

Putrescine supplementation shifts macrophage L-arginine metabolism related-genes reducing Leishmania amazonensis infection.

PLoS ONE, 2023
Leishmania is a protozoan that causes leishmaniasis, a neglected tropical disease with clinical manifestations classified as cutaneous, mucocutaneous, and visceral leishmaniasis.
Jonathan Miguel Zanatta, Stephanie Maia Acuña, Yan de Souza Angelo, Camilla de Almeida Bento, Jean Pierre Schatzman Peron, Beatriz Simonsen Stolf, Sandra Marcia Muxel   +6 more
doaj   +1 more source