Results 1 to 10 of about 27,012 (233)

Spermine is a natural suppressor of AR signaling in castration-resistant prostate cancer [PDF]

Cell Reports, 2023
Summary: In castration-resistant prostate cancer (CRPC), clinical response to androgen receptor (AR) antagonists is limited mainly due to AR-variants expression and restored AR signaling.
Xiao Li, Fei Li, Fei Ye, Haotian Guo, Wentao Chen, Jia Jin, Yiran Wang, Pengfei Dai, Huili Shi, Hongru Tao, Wenzhen Dang, Yiluan Ding, Mingchen Wang, Hualiang Jiang, Kaixian Chen, Naixia Zhang, Dong Gao, Yuanyuan Zhang, Cheng Luo   +18 more
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Application of the "Plazmontest" Software and Hardware Complex for the Determination of Spermine Concentration [PDF]

Кібернетика та комп'ютерні технології, 2023
Introduction. One of the main areas of application of SPR sensors is biochemical analysis. The "Plasmontest" device, developed at the Institute of Cybernetics of the National Academy of Sciences of Ukraine, was used for rapid diagnosis of various ...
Tetyana Lebyedyeva, Yuriy Minov, Maksym Prylutskyi, Pavlo Sutkovyi, Yurii Frolov, Pavlo Shpylovyy   +5 more
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Spermine modulation of Alzheimer’s Tau and Parkinson’s α-synuclein: implications for biomolecular condensation and neurodegeneration [PDF]

Nature Communications
Spermine, a pivotal player in biomolecular condensation and diverse cellular processes, has emerged as a focus of investigation in aging, neurodegeneration, and other diseases.
Xun Sun, Debasis Saha, Xue Wang, Cecilia Mörman, Rebecca Sternke-Hoffmann, Juan Atilio Gerez, Fátima Herranz-Trillo, Roland Riek, Wenwei Zheng, Jinghui Luo   +9 more
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Effects of spermine supplementation on the morphology, digestive enzyme activities, and antioxidant capacity of intestine in weaning rats

Animal Nutrition, 2016
The main objective of this study was to investigate the effects of different doses of spermine and its extended supplementation on the morphology, digestive enzyme activities, and intestinal antioxidant capacity in weaning rats.
Tingting Fang, Gang Jia, Hua Zhao, Xiaoling Chen, Jiayong Tang, Jing Wang, Guangmang Liu   +6 more
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Targeting spermine metabolism to overcome immunotherapy resistance in pancreatic cancer [PDF]

Nature Communications
While dysregulation of polyamine metabolism is frequently observed in cancer, it is unknown how polyamines alter the tumor microenvironment (TME) and contribute to therapeutic resistance. Analysis of polyamines in the plasma of pancreatic cancer patients
Hanshen Yang, Xiaozhen Zhang, Sirui Zhang, Yanqing Yang, Yan Chen, Yangwei Jiang, Qingsong Lu, Lingyue Liu, Mengyi Lao, Weiran Du, Kang Sun, Lihong He, Jiatao Shi, Xinyuan Liu, Jinyuan Song, Na Lu, Junming Huang, Jinyan Huang, Ruhong Zhou, Xiongbin Lu, Tingbo Liang, Xueli Bai   +21 more
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ZDHHC9 and spermine metabolism: a palmitoylation-driven pathway to prostate carcinogenesis [PDF]

Journal of Translational Medicine
Background Spermine is a natural metabolite that has been shown to hinder the progression of prostate cancer. Protein palmitoylation, a recently identified post-translational lipid modification, is catalyzed by a family of 23 enzymes known as zinc finger
Chunli Chen, Yiqun Zhang, Gaofa Wang, Yang Liu, Bin Ye, Shengqiang Zhou, Kelong Wang, Haojie Zheng, Xiaoxia Dong, Chao Luo, Junshuo Zhou, Kangkang Zeng, Caiyun Fang, Li Shen   +13 more
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Spermine treatment improves salinity tolerance in Plantago major by altering growth parameters, biochemical profiles and gene expression [PDF]

Scientific Reports
Salinity is one of the most challenging environmental factors limiting plant development and yield by interfering with key physiological and metabolic activities.
Md Mukhtar Hossain, Mojtaba Kordrostami, Fumiyuki Goto, Mehdi Rahimi   +3 more
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Spermine protects intestinal barrier integrity through ras-related C3 botulinum toxin substrate 1/phospholipase C-γ1 signaling pathway in piglets

Animal Nutrition, 2022
Weaning stress can cause tight junctions damage and intestinal permeability enhancement, which leads to intestinal imbalance and growth retardation, thereby causing damage to piglet growth and development. Spermine can reduce stress.
Guangmang Liu, Xiaomei Xu, Caimei Wu, Gang Jia, Hua Zhao, Xiaoling Chen, Gang Tian, Jingyi Cai, Jing Wang   +8 more
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Changes in Whole Blood Polyamine Levels and Their Background in Age-Related Diseases and Healthy Longevity

Biomedicines, 2023
The relationship between polyamines and healthy longevity has received much attention in recent years. However, conducting research without understanding the properties of polyamines can lead to unexpected pitfalls.
Kuniyasu Soda
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Spermine synthase [PDF]

Cellular and Molecular Life Sciences, 2009
Spermine is present in many organisms including animals, plants, some fungi, some archaea, and some bacteria. It is synthesized by spermine synthase, a highly specific aminopropyltransferase. This review describes spermine synthase structure, genetics, and function.
Anthony E, Pegg, Anthony J, Michael
openaire   +2 more sources