Results 1 to 10 of about 23,772 (188)

Spermine modulation of Alzheimer’s Tau and Parkinson’s α-synuclein: implications for biomolecular condensation and neurodegeneration [PDF]

Nature Communications
Spermine, a pivotal player in biomolecular condensation and diverse cellular processes, has emerged as a focus of investigation in aging, neurodegeneration, and other diseases.
Xun Sun, Debasis Saha, Xue Wang, Cecilia Mörman, Rebecca Sternke-Hoffmann, Juan Atilio Gerez, Fátima Herranz-Trillo, Roland Riek, Wenwei Zheng, Jinghui Luo   +9 more
doaj   +2 more sources

Targeting spermine metabolism to overcome immunotherapy resistance in pancreatic cancer [PDF]

Nature Communications
While dysregulation of polyamine metabolism is frequently observed in cancer, it is unknown how polyamines alter the tumor microenvironment (TME) and contribute to therapeutic resistance. Analysis of polyamines in the plasma of pancreatic cancer patients
Hanshen Yang, Xiaozhen Zhang, Sirui Zhang, Yanqing Yang, Yan Chen, Yangwei Jiang, Qingsong Lu, Lingyue Liu, Mengyi Lao, Weiran Du, Kang Sun, Lihong He, Jiatao Shi, Xinyuan Liu, Jinyuan Song, Na Lu, Junming Huang, Jinyan Huang, Ruhong Zhou, Xiongbin Lu, Tingbo Liang, Xueli Bai   +21 more
doaj   +2 more sources

Spermine treatment improves salinity tolerance in Plantago major by altering growth parameters, biochemical profiles and gene expression [PDF]

Scientific Reports
Salinity is one of the most challenging environmental factors limiting plant development and yield by interfering with key physiological and metabolic activities.
Md Mukhtar Hossain, Mojtaba Kordrostami, Fumiyuki Goto, Mehdi Rahimi   +3 more
doaj   +2 more sources

Spermine protects intestinal barrier integrity through ras-related C3 botulinum toxin substrate 1/phospholipase C-γ1 signaling pathway in piglets

Animal Nutrition, 2022
Weaning stress can cause tight junctions damage and intestinal permeability enhancement, which leads to intestinal imbalance and growth retardation, thereby causing damage to piglet growth and development. Spermine can reduce stress.
Guangmang Liu, Xiaomei Xu, Caimei Wu, Gang Jia, Hua Zhao, Xiaoling Chen, Gang Tian, Jingyi Cai, Jing Wang   +8 more
doaj   +1 more source

Changes in Whole Blood Polyamine Levels and Their Background in Age-Related Diseases and Healthy Longevity

Biomedicines, 2023
The relationship between polyamines and healthy longevity has received much attention in recent years. However, conducting research without understanding the properties of polyamines can lead to unexpected pitfalls.
Kuniyasu Soda
doaj   +1 more source

Spermine synthase [PDF]

Cellular and Molecular Life Sciences, 2009
Spermine is present in many organisms including animals, plants, some fungi, some archaea, and some bacteria. It is synthesized by spermine synthase, a highly specific aminopropyltransferase. This review describes spermine synthase structure, genetics, and function.
Anthony E, Pegg, Anthony J, Michael
openaire   +2 more sources

Urine spermine and multiparametric magnetic resonance imaging for prediction of prostate cancer in Japanese men

Prostate International, 2023
Objectives: To investigate the role of urine spermine and spermine risk score in predicting prostate cancer (PCa) diagnoses in combination with multiparametric magnetic resonance imaging (mpMRI).
Shuji Isotani, Peter Ka-Fung Chiu, Takeshi Ashizawa, Yan-Ho Fung, Takeshi Ieda, Toshiyuki China, Haruna Kawano, Fumitaka Shimizu, Masayoshi Nagata, Yuki Nakagawa, Satoru Muto, Ka-Leung Wong, Chi-Fai Ng, Shigeo Horie   +13 more
doaj   +1 more source

Oral Spermine Supplementation in Gestated Rabbit: A Study on Villi Height of Immature Intestines

Frontiers in Surgery, 2021
Introduction: Immature intestines are the major problem in prematurity. Postnatal oral spermine has been shown in studies to improve intestinal maturation in rats and piglets.
Riana Pauline Tamba, Yefta Moenadjat
doaj   +1 more source

Elevation of spermine remodels immunosuppressive microenvironment through driving the modification of PD-L1 in hepatocellular carcinoma

Cell Communication and Signaling, 2022
Background Spermine is frequently elevated in tumor tissues and body fluids of cancer patients and is critical for cancer cell proliferation, migration and invasion.
Hong-Xiang Shi, Chao Liang, Chao-Yan Yao, Zi-Xuan Gao, Jia Qin, Jin-Lan Cao, Ming-Zhu Zhang, Ying-Ying Li, Meng-Qing Wang, Hua Sun, Song-Qiang Xie, Dong Fang   +11 more
doaj   +1 more source

The effect of spermine on Tetranychus urticae-Cucumis sativus interaction

BMC Plant Biology, 2023
Background Two spotted spider mite, Tetranychus urticae (Acari: Tetranychidae) is one of the most important plant pests in the world. Due to increased resistance of mites to acaricides, it is necessary to use other methods such as inducing resistance in ...
Shima Shahtousi, Ladan Talaee
doaj   +1 more source