Results 21 to 30 of about 27,012 (233)

GlnA3Mt is able to glutamylate spermine but it is not essential for the detoxification of spermine in Mycobacterium tuberculosis

Journal of Bacteriology
Mycobacterium tuberculosis is well adapted to survive and persist in the infected host, escaping the host’s immune response. Since polyamines such as spermine, which are synthesized by infected macrophages, are able to inhibit the growth of M ...
Sergii Krysenko, Carine Sao Emani, Moritz Bäuerle, Maria Oswald, Andreas Kulik, Christian Meyners, Doris Hillemann, Matthias Merker, Gareth Prosser, Inken Wohlers, Felix Hausch, Heike Brötz-Oesterhelt, Agnieszka Mitulski, Norbert Reiling, Wolfgang Wohlleben   +14 more
doaj   +1 more source

Changes in the sugars, amino acids and organic acids of postharvest spermine-treated immature vegetable soybean (Glycine max L. Merr.) as determined by 1H NMR spectroscopy

Food Production, Processing and Nutrition, 2020
1H NMR spectroscopy was adopted to determine compositional changes (mainly sugars, organic acids and amino acids) involved in cold-stored immature soybean grains after exogenous spermine treatment.
Jiangfeng Song, Gang Wu, Tao Li, Chunquan Liu, Dajing Li   +4 more
doaj   +1 more source

The Involvement of Polyamines Catabolism in the Crosstalk between Neurons and Astrocytes in Neurodegeneration

Biomedicines, 2022
In mammalian cells, the content of polyamines is tightly regulated. Polyamines, including spermine, spermidine and putrescine, are involved in many cellular processes. Spermine oxidase specifically oxidizes spermine, and its deregulated activity has been
Manuela Cervelli, Monica Averna, Laura Vergani, Marco Pedrazzi, Sarah Amato, Cristian Fiorucci, Marianna Nicoletta Rossi, Guido Maura, Paolo Mariottini, Chiara Cervetto, Manuela Marcoli   +10 more
doaj   +1 more source

Polyamine Homeostasis in Snyder-Robinson Syndrome

Medical Sciences, 2018
Loss-of-function mutations of the spermine synthase gene (SMS) result in Snyder-Robinson Syndrome (SRS), a recessive X-linked syndrome characterized by intellectual disability, osteoporosis, hypotonia, speech abnormalities, kyphoscoliosis, and seizures ...
Tracy Murray-Stewart, Matthew Dunworth, Jackson R. Foley, Charles E. Schwartz, Robert A. Casero   +4 more
doaj   +1 more source

Effects of spermine on the antioxidant status and gene expression of antioxidant-related signaling molecules in the liver and longissimus dorsi of piglets

Animal, 2018
Previous studies showed that spermine could protect the organism from oxidative damage in vivo. However, in vivo information on the antioxidant-related underlying molecular mechanism of spermine is limited.
T. Fang, J. Zheng, W. Cao, G. Jia, H. Zhao, X. Chen, J. Cai, J. Wang, G. Liu   +8 more
doaj   +1 more source

Exogenous spermine attenuates rat diabetic cardiomyopathy via suppressing ROS-p53 mediated downregulation of calcium-sensitive receptor

Redox Biology, 2020
Diabetic cardiomyopathy (DCM) is a severe complication of type 1 diabetic (T1D) patients, manifested as combined diastolic and systolic dysfunction. DCM is associated with impaired calcium homeostasis secondary to decreased calcium-sensitive receptor ...
Yuehong Wang, Junting Chen, Siwei Li, Xinying Zhang, Zuoming Guo, Jing Hu, Xiaoting Shao, Ningyang Song, Yajun Zhao, Hongzhu Li, Guangdong Yang, Changqing Xu, Can Wei   +12 more
doaj   +1 more source

Transcriptomic data for analyzing global gene expression patterns in Methicillin-resistance Staphylococcus aureus in response to spermine and oxacillin stress

Data in Brief, 2018
Methicillin-resistant Staphylococcus aureus (MRSA) is a rapidly emerging bacteria causing infection, which has developed resistance to most of the beta-lactam antibiotics because of newly acquired low-affinity penicillin binding protein (PBP2a), which ...
Shrikant Pawar, Xiangyu Yao, ChungDar Lu
doaj   +1 more source

Structure and transport mechanism of P5B-ATPases

Nature Communications, 2021
In human cells, P5B‐ATPases execute export of spermine from lysosomes to the cytosol, but the mechanisms of spermine recognition, uptake and transport remain elusive. Here the authors present cryo‐EM structures of a yeast homolog of human ATP13A2‐5, Ypk9,
Ping Li, Kaituo Wang, Nina Salustros, Christina Grønberg, Pontus Gourdon   +4 more
doaj   +1 more source

Metabolism of N-alkylated spermine analogues by polyamine and spermine oxidases [PDF]

Amino Acids, 2009
N-alkylated polyamine analogues have potential as anticancer and antiparasitic drugs. However, their metabolism in the host has remained incompletely defined thus potentially limiting their utility. Here, we have studied the degradation of three different spermine analogues N,N'-bis-(3-ethylaminopropyl)butane-1,4-diamine (DESPM), N-(3-benzyl ...
Merja R, Häkkinen, Mervi T, Hyvönen, Seppo, Auriola, Robert A, Casero, Jouko, Vepsäläinen, Alex R, Khomutov, Leena, Alhonen, Tuomo A, Keinänen   +7 more
openaire   +2 more sources

Regulatory Effect of Spermine on Growth and Antioxidant System in Tomato Seedlings Grown in the Presence of Cadmium [PDF]

Journal of Stress Physiology & Biochemistry, 2019
The protective role of exogenous supplied polyamines such as spermine in detoxifying the cadmium induced toxicity was studied in the tomato plants Solanum lycopersicum, we applied a dose of (1 mM) spermine with cadmium (0, 20 and 100 µM) for 7 days.
Dorra El Gueder, Rihab Ben Fattoum, Mohamed Debouba, Ahlem Ben Khedher, Houda Gouia, Chiraz Haouari Chaffei   +5 more
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