Results 41 to 50 of about 23,772 (188)
Advanced ScienceDecreased plasma spermine levels are associated with kidney dysfunction. However, the role of spermine in kidney disease remains largely unknown. Herein, it is demonstrated that spermine oxidase (SMOX), a key enzyme governing polyamine metabolism, is ...
Dan Luo +13 more
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Spermine and L-name pretreatment effects on polyamine and nitric oxide metabolism in rat brain during seizures [PDF]
Journal of Medical Biochemistry, 2007 In the CNS polyamines can exert opposite effects, depending on the concentration and conditions in the cell. Protective or neurotoxic polyamine effects were documented during seizures and repeated CNS excitation.
Stojanović Ivana +4 more
doaj
Antimycotic Effect of Spermine.
Experimental Biology and Medicine, 1958 Summary1) Spermine inhibited growth of several species of yeasts, Saccharomyces and Debaryomyces species being the most sensitive. The antimycotic effect of spermine was more pronounced at an alkaline pH and was antagonized by inorganic salts. The adsorption of spermine by yeast cells was significantly smaller than by Staph. aureus.
S, RAZIN, A, COHEN, R, ROZANSKY
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Advanced Science, EarlyView.This study investigates the genetic and microbial factors influencing the susceptibility of Diaphorina citri to the citrus greening pathogen Candidatus Liberibacter asiaticus (CLas), employing a microbiome Genome Wide Association Study. The research identifies a key gene encoding an MFS‐type transporter contributing to CLas infectivity and abundance in
Kai Liu +12 more
wiley +1 more source
RIPK3 Orchestrates Scar‐Associated Macrophage Dysfunction to Drive Pulmonary Fibrosis
Advanced Science, EarlyView.Beyond signaling cell death, RIPK3 emerges as a critical metabolic regulator in pulmonary fibrosis. This research reveals that RIPK3 promotes PI3K‐AKT signaling in scar‐associated macrophages to fuel polyamine synthesis, independent of its kinase activity.
Tao Yang +12 more
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Nephrotoxic Action of Spermine
Experimental Biology and Medicine, 1952 ConclusionsSpermine administered parenterally is highly active in producing renal injury in mice, rats, and rabbits. This property was not observed for spermidine, putrescine, or cadaverine.
S M, ROSENTHAL +2 more
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Advanced Science, EarlyView.SJNPs co‐deliver JHU083 and spermine to reprogram macrophage–neuron immunometabolic crosstalk in sepsis. By suppressing pro‐inflammatory M1 polarization and promoting NGF‐mediated neurotrophic signaling, SJNPs preserve pulmonary neuronal integrity, alleviate lung injury, and improve survival in murine sepsis models.
Wenhui Wang +11 more
wiley +1 more source
Difluoromethylornithine rebalances aberrant polyamine ratios in Snyder–Robinson syndrome
EMBO Molecular Medicine, 2023 Snyder–Robinson syndrome (SRS) results from mutations in spermine synthase (SMS), which converts the polyamine spermidine into spermine. Affecting primarily males, common manifestations of SRS include intellectual disability, osteoporosis, hypotonia, and
Tracy Murray Stewart +8 more
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Advanced Science, EarlyView.Resident myonuclei are the molecular “control centers” for large multinuclear muscle fibers. It is presumed that, with aging, these control centers become compromised and contribute to delayed or blunted muscle adaptive potential. This study is a detailed roadmap that exposes how young versus aged myonuclei respond to a hypertrophic loading stimulus ...
Pieter J. Koopmans +8 more
wiley +1 more source
SPERMINE OXIDASE: AN AMINE OXIDASE WITH SPECIFICITY FOR SPERMINE AND SPERMIDINE [PDF]
Journal of Experimental Medicine, 1953 Sheep serum and bovine serum contain an enzyme which brings about a rapid oxidative deamination of certain biological amines. This enzyme differs from previously described amine oxidases in several regards and especially in its substrate specificity.
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