Results 51 to 60 of about 23,772 (188)

Genetic and Phenotypic Features of the Five Known Polyaminopathies: A Critical Narrative Review

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Polyaminopathies are a recently described family of rare genetic neurodevelopmental disorders. Polyaminopathies disrupt the biosynthesis of the primary polyamines: putrescine, spermidine, and spermine. Snyder–Robinson syndrome results from hemizygous loss‐of‐function variants in the spermine synthase (SMS) gene, resulting in decreased or ...
Elizabeth A. VanSickle, Sara M. Sarasua, Tracy Lowe, Christopher L. Farrell, Luigi Boccuto, Charles Schwartz, Anthony E. Pegg, Angela Peron, Victor Faundes, Mythily Ganapathi, Wendy K. Chung, Alban Ziegler, Floris Hofstede, Clément Prouteau, Katharina Steindl, Colleen Olson, Orrin Devinsky, Teresa L. Mastracci, Robert A. Casero Jr., Tracy Murray Stewart, Susan Gilmour, Teri Koerner, Mary Jo Kutler, Surender Rajasekaran, Julianne Michael, André S. Bachmann, Caleb P. Bupp   +26 more
wiley   +1 more source

Antibacterial Action of Oxidized Spermine [PDF]

Journal of General Microbiology, 1964
SUMMARY: Spermine oxidized by partially purified serum amine oxidase inhibited the growth of a variety of Gram-positive and Gram-negative bacteria. This inhibition of growth was not antagonized by calcium ion, and occurred over a wide pH range. Inactivation increased with time and temperature of incubation.
U, BACHRACH, S, PERSKY
openaire   +2 more sources

Synthesis and Characterization of Ag–Fe Bimetallic Nanoparticles and Nanocomposites (Alloys and Core–Shells) for Photocatalytic Degradation of Bromophenol Blue Dye Using Grewia optiva Leaf Extract

Asia-Pacific Journal of Chemical Engineering, EarlyView.
ABSTRACT Ag–Fe bimetallic nanoparticles (alloy and core–shell structures) were synthesized using Grewia optiva leaf extract through a green, phytochemical‐mediated approach. The effects of pH, temperature, extract concentration, and Ag:Fe molar ratio on nanoparticle formation were systematically optimized, enabling size‐controlled and morphologically ...
Sehrish Asad, Waheed Murad, Natasha Anwar, Khushbakht Asad, Muhammad Salman Khan, Shohreh Azizi, Malik Maaza   +6 more
wiley   +1 more source

Biomaterial design strategies for enhancing mitochondrial transplantation therapy

BMEMat, EarlyView.
Biomaterials to facilitate mitochondrial transplantation therapy: biomaterials as barriers to protect mitochondria from pathophysiological microenvironments, like osmotic stress caused by the excessive concentration of calcium ion, reactive oxygen species, and advanced glycation end products; biomaterials integrating with biochemical cues to improve ...
Shaoyang Kang, Yushan Zhang, Hang Li, Sirui Peng, Donghao Lyu, Chunxiao Zhou, Sheng Ding, Zujian Feng, Pingsheng Huang, Chuangnian Zhang, Hongjun Wang, Deling Kong, Weiwei Wang   +12 more
wiley   +1 more source

Sulforaphane potentiates RNA damage induced by different xenobiotics. [PDF]

PLoS ONE, 2012
The isothiocyanate sulforaphane (SFN) possesses interesting anticancer activities. However, recent studies reported that SFN promotes the formation of reactive oxygen species (ROS) as well as DNA breakage.We investigated whether SFN is able to damage RNA,
Carmela Fimognari, Monia Lenzi, Piero Sestili, Eleonora Turrini, Lorenzo Ferruzzi, Patrizia Hrelia, Giorgio Cantelli-Forti   +6 more
doaj   +1 more source

Reprogramming tumor immune microenvironment by ultrasound‐responsive nanoplatforms for enhanced cancer immunotherapy

BMEMat, EarlyView.
Ultrasound‐responsive nanoplatforms reprogram the tumor immune microenvironment by targeting tumor cells, immune cells, and non‐immune stromal cells to enhance the efficacy of cancer immunotherapy. Abstract Cancer immunotherapy represents a significant advancement in cancer treatment by enhancing the specific recognition and elimination of cancer cells.
Shilong Zhao, Rui Qu, Zan Dai, Xiqun Jiang, Xu Zhen   +4 more
wiley   +1 more source

Interkingdom Interactions in the Gut: Ecological Mechanisms, Homeostasis, and Therapeutic Modulation

Gut Medicine, EarlyView.
ABSTRACT The gut microbiota constitutes a highly complex and dynamic ecosystem that profoundly influences host physiology, metabolism, and immunity. This review provides an integrative overview of the mechanisms through which gut microorganisms—particularly bacteria and fungi—interact with host cells and with each other to maintain intestinal ...
Rui‐Qi Wei, Xin‐Wei Sun, Hao‐Jie Huang, Yu‐Zhi Zhao, Shuang‐Jiang Liu, Chang Liu   +5 more
wiley   +1 more source

Overexpression of SAMDC1 gene in Arabidopsis thaliana increases expression of defense-related genes as well as resistance to Pseudomonas syringae and Hyaloperonospora arabidopsidis

Frontiers in Plant Science, 2014
It has been previously described that elevation of endogenous spermine levels in Arabidopsis could be achieved by transgenic overexpression of S-Adenosylmethionine decarboxylase (SAMDC) or Spermine synthase (SPMS).
Francisco eMarco, Enrique eBusó, Pedro eCarrasco   +2 more
doaj   +1 more source

Monosaccharide‐Based Macrocyclic Receptors—History and Recent Applications

Helvetica Chimica Acta, EarlyView.
This perspective provides an overview of most common applications of monosaccharide‐based macrocycles in molecular recognition over the past four decades. The most recent achievements, such as fluorescent ion sensing and selective amino acid binding in aqueous media, including the work from the author's lab, are highlighted. Potential future directions
Bartosz Lewandowski
wiley   +1 more source

Targeting Microbiome Metabolites: Reshaping Immunotherapy and Clinical Management Strategies for Colorectal Cancer

iMetaMed, EarlyView.
The occurrence and progression of colorectal cancer are intricately linked to metabolites produced by the gut microbiota. Metabolites generated by pathogenic microbial communities can promote colorectal cancer development by reshaping the immune microenvironment.
Xinrui Yang, Ke Zhang, Lijie Xia, Jinyao Li   +3 more
wiley   +1 more source