Results 141 to 150 of about 150,601 (174)
Spermine Oxidase: Ten Years After
Amino Acids, 2012 ""Spermine oxidase (SMO) was discovered much. more recently than other enzymes involved in polyamine. metabolism; this review summarizes 10 years of researches. on this enzyme. Spermine oxidase (SMO) is a FADdependent.
Manuela Cervelli +2 more
exaly +5 more sources
Inhibition of Acetylpolyamine and Spermine Oxidases by the Polyamine Analogue Chlorhexidine. [PDF]
Journal of Enzyme Inhibition and Medicinal Chemistry, 2013 ""Acetylpolyamine and spermine oxidases are involved in the catabolism of polyamines. The discovery of selective. inhibitors of these enzymes represents an important tool for the development of novel anti-neoplastic drugs. Here, a.
Manuela Cervelli +2 more
exaly +6 more sources
Spermine Oxidase: An Amine Oxidase With Specificity for Spermine and Spermidine. [PDF]
Journal of Experimental Medicine, 1953 Sheep serum and bovine serum contain an enzyme which brings about a rapid oxidative deamination of certain biological amines. This enzyme differs from previously described amine oxidases in several regards and especially in its substrate specificity.
James G Hirsch
exaly +3 more sources
Genetic and Epigenetic Influences on Expression of Spermine Synthase and Spermine Oxidase in Suicide Completers [PDF]
International Journal of Neuropsychopharmacology, 2010 Alterations in the levels of spermine synthase (SMS) and spermine oxidase (SMOX), two enzymes involved in polyamine metabolism, have previously been observed in brains of suicide completers. To characterize the roles played by genetic and epigenetic factors in determining expression levels of these genes, as well as to identify potential mechanisms by ...
Laura M Fiori, Gustavo Turecki
exaly +3 more sources
Characterization of a Cyclic Compound Formed After Spermine Oxidation by Lentil Amine Oxidase
IUBMB Life, 1997 Spermine is a substrate of lentil seedling amine oxidase and is oxidized at terminal amino groups to a dialdehyde: 2 mol of hydrogen peroxide and two mol of ammonia per mol of spermine are formed.
Maurizio Paci +2 more
exaly +3 more sources
Free Radical Biology and Medicine, 2017 Spermine oxidase oxidizes spermine to produce H2O2, spermidine, and 3-aminopropanal. It is involved in cell drug response, apoptosis, and in the etiology of several pathologies, including cancer.
Stefania Sabatini +2 more
exaly +3 more sources
Free Radical Biology and Medicine, 2015 The uptake of spermine into mammalian mitochondria indicated the need to identify its catabolic pathway in these organelles. Bovine liver mitochondria were therefore purified and their capacity for natural polyamine uptake was verified.
Annarita Stringaro +2 more
exaly +2 more sources
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Synthesis of 2,11-Bis(Methylidene)Spermine, a New Inhibitor of Spermine Oxidase
Russian Journal of Bioorganic Chemistry, 2016Earlier unknown 1,12-diamino-2,11-bis(methylidene)-4,9-diazadodecane, which may be considered as an enzyme-activated inhibitor of spermine oxidase, was synthesized in 6 steps starting from 2-chloromethyl-3-chloropropene-1 in a high yield. Application of newly synthesized spermine analogue for the inhibition of spermine oxidase was discussed.
Sergey Kochetkov +2 more
exaly +2 more sources
Inhibition of Polyamine and Spermine Oxidases by Polyamine Analogues
FEBS Journal, 2006Polyamine oxidase (PAO) and spermine oxidase (SMO) are involved in the catabolism of polyamines – basic regulators of cell growth and proliferation. The discovery of selective inhibitors of PAO and SMO represents an important tool in studying the involvement of these enzymes in polyamine homeostasis and a starting point for the development of novel ...
Alessandra Cona +2 more
exaly +6 more sources
Pentamine as a Substrate for Measuring Spermine Oxidase Activity
2017A method for determining spermine oxidase activity is described using the pentamine 1,16-diamino-4,8,13-triazahexadecane (3343) as the substrate, coupled with o-phthalaldehyde-post-label ion-exchange HPLC. The synthesis of 3343 is also described.
Koichi, Takao, Yoshiaki, Sugita
openaire +2 more sources