Results 151 to 160 of about 150,601 (174)

Amine oxidase-based biosensors for spermine and spermidine determination

Analytical and Bioanalytical Chemistry, 2014
The present work describes the development and optimization of electrochemical biosensors for specific determination of the biogenic polyamine spermine (Spm) and spermidine (Spmd) whose assessment represents a novel important analytical tool in food analysis and human diagnostics.
BOFFI, Alberto, FAVERO, Gabriele, FEDERICO, RODOLFO, MACONE, ALBERTO, ANTIOCHIA, RICCARDA, TORTOLINI, CRISTINA, SANZO', GABRIELLA, MAZZEI, Franco   +7 more
openaire   +2 more sources

Development of Irreversible Inactivators of Spermine Oxidase and N1-Acetylpolyamine Oxidase

Biological and Pharmaceutical Bulletin, 2014
Three functional groups (2-propenyl, 2-propynyl, and 2,3-butadienyl) were introduced onto one of the terminal amino groups of spermidine. Of the six compounds synthesized, N-(3-aminopropyl)-N'-2,3-butadienyl-1,4-butanediamine (N(8)-butadienyl Spd) and N-[3-(2,3-butadienylamino)propyl]-1,4-butanediamine (N(1)-butadienyl Spd) irreversibly inactivated ...
Keijiro Samejima, Yoshiaki Sugita, Masao Kawakita   +2 more
exaly   +3 more sources

Astrocyte-Dependent Vulnerability to Excitotoxicity in Spermine Oxidase-Overexpressing Mouse

NeuroMolecular Medicine, 2015
Transgenic mice overexpressing spermine oxidase (SMO) in the cerebral cortex (Dach-SMO mice) showed increased vulnerability to excitotoxic brain injury and kainate-induced epileptic seizures. To investigate the mechanisms by which SMO overexpression leads to increased susceptibility to kainate excitotoxicity and seizure, in the cerebral cortex of Dach ...
CERVETTO, CHIARA, VERGANI, LAURA, PASSALACQUA, MARIO, RAGAZZONI, MILENA, VENTURINI, ARIANNA, Cecconi, Francesco, Berretta, Nicola, Mercuri, Nicola, D’Amelio, Marcello, MAURA, GUIDO, Mariottini, Paolo, VOCI, ADRIANA, MARCOLI, MANUELA, Cervelli, Manuela   +13 more
openaire   +4 more sources

Spermine oxidase and benzylamine oxidase. Distribution, development and substrate specificity

Proceedings of the Royal Society of London. Series B. Biological Sciences, 1962
Abstract A survey has been made of the distribution of the two types of amine oxidase that occur in mammalian blood plasma. Spermine oxidase has been found in all ruminants (Ruminantia and Tylopoda) examined, and also in the hippopotamus and two members of the order Hyracoidea.
H. Blaschko, Rosemary Bonney
openaire   +1 more source

Plasma Spermine Oxidase in relation to Fermentation in Hippopotamus Stomach

Nature, 1968
THE communication by Thurston, Noirot-Timothee and Arman1 is of interest to the enzymologist. The authors relate the occurrence of ciliate protozoa in the stomach of Hippopotamus amphibius, a non-ruminant ungulate, to the fact that in this species, as in the ruminants, fermentation takes place in the stomach.
openaire   +2 more sources

Spermine oxidase is upregulated and promotes tumor growth in hepatocellular carcinoma

Hepatology Research, 2018
AimThe polyamine catabolic enzyme, spermine oxidase (SMOX) is upregulated in chronic inflammatory conditions and linked to increased reactive oxygen species and DNA damage in various forms of cancers. The present study aims to explore the expression pattern and biological function of SMOX in hepatocellular carcinoma (HCC).MethodsWe used quantitative ...
Hu, TT, Sun, DL, Zhang, J, Xue, RY, Janssen, HLA, Tang, WQ, Dong, L   +6 more
openaire   +2 more sources

Quantification of spermine oxidase (SMOX) activity in tissues by HPLC

The polyamine oxidases, SMOX and PAOX, are enzymes involved in the normal metabolism of polyamines. Both enzymes are implicated in numerous human diseases including cancer, reperfusion injury, and neurodegenerative diseases. The ability to directly measure the activity of these enzymes is imperative in understanding their role in human health and ...
Jackson R, Foley, Cassandra E, Holbert
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Discovery and Optimization of a Novel Series of Pyrazolopyrimidines as Spermine Oxidase Inhibitors

Journal of Medicinal Chemistry
Abstract Spermine oxidase (SMOX) is associated with pathological processes in cancer initiation and progression, driving interest in the search for SMOX inhibitors. Currently available inhibitors exhibit moderate activity and limited selectivity toward other polyamine-metabolizing enzymes such as polyamine oxidase (PAOX), underscoring
Josep Llaveria, Suraj Adhikary, Christophe Buyck, Santiago Cañellas, Jose Maria Cid, Ben Danna, Francisca Delgado, Elsie Diaz, Alejandro Diéguez-Vázquez, Lichao Fang, Froylan Omar Fernandez Candelaria, Garrett Gibbons, Vincent N. A. Klaren, Daniel J. Krosky, Antonietta Impagliazzo, Maria Lourdes Linares, Carolina Martinez Lamenca, Antonio Misale, Meghan Pryor, Jackie Shang, Javier Suarez   +20 more
openaire   +2 more sources

spermine oxidase 1.5.3.16

2013
Dietmar Schomburg, Ida Schomburg
openaire   +1 more source

The formation of spermidine from spermine by serum amine oxidase

Biochimica et Biophysica Acta, 1960
U, BACHRACH, R, BAR-OR
openaire   +2 more sources