Increased spermine oxidase (SMO) activity as a novel differentiation marker of myogenic C2C12 cells
, 2009 Spermine oxidase (SMO) is a FAD-containing enzyme involved in animal cell polyamines (PA) homeostasis, selectively active on spermine and producing H2O2, spermidine, and the 3-aminopropanal.
Elisabetta Ferraro +18 more
core +2 more sources
Molecular Oncology, Volume 20, Issue 6, Page 1556-1590, June 2026.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Leveraging Macrophage Metabolic Reprogramming for Enhanced Anti‐Tumor Immunity
Advanced Science, Volume 13, Issue 33, 15 June 2026.Tumor‐associated macrophages (TAMs) are key regulators of the tumor microenvironment (TME), with their metabolic states playing a critical role in tumor progression or regression. This review summarizes current understanding of TAM metabolic plasticity alongside cutting‐edge bioengineering innovations, outlining a roadmap for transforming the ...
Zhiyun Liu +8 more
wiley +1 more source
npj Parkinson's DiseaseParkinson’s Disease (PD) is a neurodegenerative disorder characterized by α-synuclein accumulation and aggregation, leading to disrupted cellular homeostasis, impaired mitochondrial function, and neuroinflammation, ultimately causing neuronal death ...
Bedri Ranxhi +7 more
doaj +1 more source
Molecular evolution of the polyamine oxidase gene family in Metazoa
BMC Evolutionary Biology, 2012 Background Polyamine oxidase enzymes catalyze the oxidation of polyamines and acetylpolyamines. Since polyamines are basic regulators of cell growth and proliferation, their homeostasis is crucial for cell life.
Polticelli Fabio +4 more
doaj +1 more source
Biomaterial design strategies for enhancing mitochondrial transplantation therapy
BMEMat, Volume 4, Issue 2, June 2026.Biomaterials to facilitate mitochondrial transplantation therapy: biomaterials as barriers to protect mitochondria from pathophysiological microenvironments, like osmotic stress caused by the excessive concentration of calcium ion, reactive oxygen species, and advanced glycation end products; biomaterials integrating with biochemical cues to improve ...
Shaoyang Kang +12 more
wiley +1 more source
Epileptic seizures and oxidative stress in a mouse model over-expressing spermine oxidase
, 2019 Several studies have demonstrated high polyamine levels in brain diseases such as epilepsy. Epilepsy is the fourth most common neurological disorder and affects people of all ages. Excitotoxic stress has been associated with epilepsy and it is considered
Pietropaoli S. +13 more
core +2 more sources
Perturbation of spermine synthase Gene Expression and Transcript Profiling Provide New Insights on the Role of the Tetraamine Spermine in Arabidopsis Defense against Pseudomonas viridiflava1[C][W] [PDF]
, 2011 The role of the tetraamine spermine in plant defense against pathogens was investigated by using the Arabidopsis (Arabidopsis thaliana)-Pseudomonas viridiflava pathosystem.
María Elisa Gonzalez +23 more
core +1 more source
THE INHIBITION OF AMINE OXIDASE AND SPERMINE OXIDASE BY AMIDINES [PDF]
British Journal of Pharmacology and Chemotherapy, 1955 H, BLASCHKO, J M, HIMMS
openaire +2 more sources
Polyamine Catabolism Revisited: Acetylpolyamine Oxidase Plays a Minor Role due to Low Expression
CellsBiogenic polyamines are ubiquitous compounds. Dysregulation of their metabolism is associated with the development of various pathologies, including cancer, hyperproliferative diseases, and infections.
Olga N. Ivanova +14 more
doaj +1 more source