Results 61 to 70 of about 150,601 (174)
Mechanism of cell death induced by spermine and amine oxidase in mouse melanoma cells [PDF]
, 2008 Polyamines such as spermine, spermidine and putrescine are necessary for cell proliferation and are detected at higher concentrations in most tumor tissues, compared to normal tissues.
A. Tanel +5 more
core
The Glu216/Ser218 pocket is a major determinant of spermine oxidase substrate specificity
, 2014 SMO (spermine oxidase) and APAO (acetylpolyamine oxidase) are flavoenzymes that play a critical role in the catabolism of polyamines. Polyamines are basic regulators of cell growth and proliferation and their homoeostasis is crucial for cell life ...
Rodolfo Federico +21 more
core +1 more source
Food Safety and Health, Volume 4, Issue 4, Page 875-892, October 2026.This review elucidates the formation pathways and detection technologies for ethyl carbamate, biogenic amines, and higher alcohols in Huangjiu. It concludes that integrated control frameworks are essential to decouple safety risks from the metabolic processes responsible for flavor development.
Lulu Liu +5 more
wiley +1 more source
Self-Assembled Alkylated Polyamine Analogs as Supramolecular Anticancer Agents
Molecules, 2022 Conformationally restrained polyamine analog PG11047 is a well-known drug candidate that modulates polyamine metabolism and inhibits cancer cell growth in a broad spectrum of cancers. Here, we report a structure–activity relationship study of the PG11047
Diptesh Sil +10 more
doaj +1 more source
Ischemic Stroke and Traumatic Brain Injury: Epidemiology, Molecular Pathways, and Emerging Therapies
MedComm, Volume 7, Issue 10, October 2026.Schematic overview of secondary brain injury after ischemic stroke and traumatic brain injury. Both conditions trigger endothelial cell dysfunction, pericyte contraction, and upregulated AQP4 expression in astrocytic end‐feet, leading to blood–brain barrier disruption.
Mengzhao Feng +7 more
wiley +1 more source
Bovine liver mitochondria: constitutive presence of a novel enzyme with spermine oxidase properties
, 2016 Spermine is taken up by mammalian mitochondria and this process needs to identify its catabolic pathway in such organelles. Therefore, the ability of purified bovine liver mitochondria for natural polyamine uptake was verified.
Roberto Stevanato +9 more
core +1 more source
Journal of Cellular and Molecular Medicine, Volume 30, Issue 19, October 2026.ABSTRACTThe effects and mechanisms of Huangqi Guizhi Wuwu Decoction (HGWD) in cancer cachexia remain unclear. We generated an in vivo cachexia model by implanting Lewis lung carcinoma cells into mice and treated animals with HGWD. We evaluated muscle function using grip strength and wire‐grip tests.
Yingjia Zhou +9 more
wiley +1 more source
Initial characerization of human spermine oxidase [PDF]
, 2009 The flavoprotein spermine oxidase catalyzes the oxidation of spermine and oxygen to spermidine, 3-aminopropanol, and hydrogen peroxide. To allow mechanistic studies of the enzyme, methods have been developed to obtain large amounts of purified ...
Juarez, Paul Ramon
core
Medical Sciences, 2018 Polyamine levels are elevated in breast tumors compared to those of adjacent normal tissues. The female sex hormone, estrogen is implicated in the origin and progression of breast cancer.
T. J. Thomas, Thresia Thomas
doaj +1 more source
Plant Biotechnology Journal, Volume 24, Issue 10, Page 5440-5459, October 2026.ABSTRACT Drought stress severely restricts rice productivity, necessitating strategies to enhance stress resilience. Here, we identify translation termination as a tunable regulatory node for stress adaptation. Using 25 rounds of SELEX, we isolated RTAR, an RNA aptamer that binds the rice eukaryotic release factor 1 (OseRF1) with nanomolar affinity ...
Shuangfeng Dai +7 more
wiley +1 more source