Results 221 to 230 of about 39,549 (288)

Aging‐Derived Alterations in Genomic, Immune, and Metabolic Networks: Implications for Cancer Development and Therapy

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ageing acts as a double‐edged sword in cancer. In the elderly, open chromatin, immunosenescence, and chronic inflammation drive SASP (IL‐6, MMPs), MDSC accumulation and T‐cell suppression, fostering tumor‐promoting microenvironments and limited therapeutic benefit.
Qi Wang, Xue Sun, Xinhao Han, Xingda Zhang, Wenzheng Wang, Hongbin Wang, He Ren, Lina Gu   +7 more
wiley   +1 more source

Integration of network pharmacology, metabolomics and lipidomics for clarifying the role of sphingolipid metabolism in the treatment of liver cancer by regorafenib

Hua Mu, Jinlong Hu, Zhikun Lin, Letian Wei, Qi Li, Xiaolin Wang, Pengyu Geng, Rui Zhong, Shimeng Cui, Wenru Liu, Chunxiu Hu, Guowang Xu, Guang Tan   +12 more
openalex   +1 more source

Unraveling Lysosomal Exocytosis: From Molecular Mechanisms to Physiological Functions

Traffic, Volume 27, Issue 1, March 2026.
Lysosomal exocytosis is propelled by specific molecular mechanisms that direct its microtubule‐dependent transport and subsequent fusion with the plasma membrane. This process fulfills essential physiological functions such as plasma membrane repair, maintenance of cellular homeostasis, and participation in signal transduction.
Shanshan Jiang, Jingyi Fu, Shan Li, Zehui Li, Qirui Zhao, Yuqi Yin, Mei Yang, Yonghua Wang   +7 more
wiley   +1 more source

Combined Weight Loss and Exercise Training Alters Skeletal Muscle Subcellular Lipid Localization and Intermuscular Adipose Tissue Cellular Composition. [PDF]

Diabetes
Zemski Berry K, Garfield A, Whytock KL, Macias E, Zarini S, Jambal P, Stepaniak T, Bowen S, Perreault L, Johnson C, Kahn D, Kerege A, Tamburini IJ, Nguyen CM, Viesi CH, Seldin M, Sun Y, Walsh M, Sparks LM, Bergman BC.   +19 more
europepmc   +1 more source

The role of cytokines in ovarian cancer drug resistance

International Journal of Cancer, Volume 158, Issue 4, Page 821-834, 15 February 2026.
Abstract Ovarian cancer is the leading cause of death among women diagnosed with female reproductive system cancers. While significant advances have been made in treating various types of cancer, progress in ovarian cancer treatment over the past 20 years has been minimal, and the treatment course of ovarian cancer is not linear. Although many patients
Lu Wang, Yunxia Zang, Rebeka Dejenie, Junyuan Bing, Shixia Dong, Yanfei Zhang, Yi Zhu, Jingjing Li   +7 more
wiley   +1 more source

Retraction Note: Long-term use of fluoxetine accelerates bone loss through the disruption of sphingolipids metabolism in bone marrow adipose tissue. [PDF]

Transl Psychiatry
Zhang H, Li K, Zhao Y, Zhang Y, Sun J, Li S, Lin G.   +6 more
europepmc   +1 more source

The Sphingolipid-Modulating Drug Opaganib Protects against Radiation-Induced Lung Inflammation and Fibrosis: Potential Uses as a Medical Countermeasure and in Cancer Radiotherapy [PDF]

Lynn W. Maines, Staci N. Keller, Ryan A. Smith, Cecelia L. Green, Charles D. Smith   +4 more
openalex   +1 more source

Molecular Insights Into Heat Stress Resilience in Chickpea Near‐Isogenic Lines

Plant, Cell &Environment, EarlyView.
Miriam Negussu, Maria Ventimiglia, Chiara Vergata, Matteo Buti, David J. Bonfil, Dudy Bar‐Zvi, Michele Zaccai, Federico Martinelli   +7 more
wiley   +1 more source

Metabolic reprogramming of efferocytosis in the tumour microenvironment: From apoptotic‐cell clearance to therapeutic targeting

Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.
This review systematically deconstructs the pathological efferocytic—metabolic axis in tumours, framing it as a three‐stage, self‐reinforcing cycle: from metabolite‐driven macrophage recruitment, through hijacked surface recognition, to post‐phagocytic metabolic reprogramming that locks in immunosuppression.
Qianlu Yang, Jie Yan, Qianxi Yang
wiley   +1 more source

Lipidomic Characterization of Muscle and Head of <i>Litopenaeus vannamei</i> Exposed to <i>Lactococcus lactis</i> D1813 at Varied Levels of Salinity and Dissolved Oxygen. [PDF]

Food Sci Nutr
Adil M, Xiao X, Waseem M, Afraz MT, Javed MR, Alohali BM, Mohamed Ahmed IA, Manzoor MF, Madilo FK.   +8 more
europepmc   +1 more source