Results 241 to 250 of about 66,876 (325)

F13A1‐Mediated Macrophage Activation Promotes MASH Progression via the PKM2/HIF1A Pathway

Advanced Science, Volume 13, Issue 13, 3 March 2026.
In fatty liver disease, hepatocytes exposed to palmitate release S1P, which activates calcium signaling in macrophages. Elevated calcium enhances the activity of F13A1, driving PKM2 dimerization. The PKM2 dimers cause Warburg effect, translocate to the nucleus, cooperate with HIF1A, and upregulate IL1B expression, ultimately promoting classical ...
Qianrang Lu, Meiching Ong, Xuewen Yi, Muqiong Xing, Xinyao Tian, Ke Zhang, Ling Lu, Hao Wang, Xiaohan Lin, Jun Fang, Aibo Mu, Jiaying Cao, Jingyu Jiang, Feng Gao, Hongjun Li, Baohong Wang, Qi Ling   +16 more
wiley   +1 more source

Dual Biological Potential: Anticancer and Antibacterial Activities of Bis-α, ω-Bifunctional Sphingolipids from the Marine Sponge Oceanapia ramsayi. [PDF]

ChemMedChem
Keneni DA, Njanje I, Kalinski JJ, Isaacs M, Swart T, Davison C, de la Mare JA, Dorrington RA.   +7 more
europepmc   +1 more source

Spatial lipidomics reveals sphingolipid metabolism as anti-fibrotic target in the liver

Gruevska A, Leslie J, Perpinan E, Maude H, Collins AL, Johnson S, Evangelista Linden L, Sabey E, French Allen J., White S, Moir J, Robinson SM, Alrawashdeh W, Thakkar R, Forlano R, Manousou P, Goldin Jackson R, Carling D, Hoare M, Thursz M, Mann DA, Cebola I, Posma JM, Safinia N, Oakley F, Hall Z   +25 more
openalex  

The role of vitamin D receptor signaling in hair follicle health and alopecia: Current understanding and therapeutic implications

Journal of Cell Communication and Signaling, Volume 20, Issue 1, March 2026.
The vitamin D receptor (VDR) regulates hair follicle biology through ligand‐dependent and ligand‐independent mechanisms by heterodimerizing with retinoid X receptor, recruiting coactivator complexes, and activating target genes including Wnt inhibitors, hair keratins, and cell cycle regulators.
Liancheng Guan, Fan Yang, Meijuan Li, Yujia Chen, Zexin Zhao, Hongxia Li, Deping Luo, Qian Li, Yunzhi Chen   +8 more
wiley   +1 more source

Metabolic signatures in sciatic nerve of PMP22 transgenic rats provide insights into the pathogenesis of charcot-marie-tooth disease type 1 A. [PDF]

Sci Rep
Muller A, Grove K, Christen I, Kreider J, Santos C, Hoque S, Bidinosti M, Hatakeyama S, Zhang J.   +8 more
europepmc   +1 more source

Drosophila models uncover substrate channeling effects on phospholipids and sphingolipids in peroxisomal biogenesis disorders

Michael F. Wangler, Yu-Hsin Chao, Mary R. Roth, Ruth Welti, James A. McNew   +4 more
openalex   +1 more source

SMPD1 as a Potential Prognostic Biomarker in Glioma Is Associated With an Immunosuppressive Microenvironment

CNS Neuroscience &Therapeutics, Volume 32, Issue 3, March 2026.
SMPD1 expression varies across different glioma subtypes and clinical features and is associated with poor prognosis. High SMPD1 levels are linked to an immunosuppressive tumor microenvironment, characterized by suppressed M1 macrophage polarization and enhanced M2‐like signatures.
Yanan Xu, Xing Liu, Boya Xu, Qiuling Li, Luofei Zhang, Cao Li, Zhigang Zhao   +6 more
wiley   +1 more source

Non‐HLA Risk Loci ERBB3/IKZF4 and ERBB2/IKZF3/GSDMB/ORMDL3 Interact to Influence Progression of Autoimmunity in Relatives of T1D Patients

Diabetes/Metabolism Research and Reviews, Volume 42, Issue 3, March 2026.
ABSTRACT Aim The genetic loci, ERBB2/IKZF3/GSDMB/ORMDL3 on chromosome 17q, and ERBB3/IKZF4 on chromosome 12q represent confirmed non‐HLA risk factors for the development of autoimmunity and progression to type 1 diabetes (T1D). It is unknown whether both regions can interact to influence the progression of T1D.
Ina M. Mertens, Bart Keymeulen, Frans K. Gorus, Mark Van De Casteele, the Belgian Diabetes Registry   +4 more
wiley   +1 more source

Altered Sphingolipids, Glycerophospholipids, and Lysophospholipids Reflect Disease Status in Idiopathic Steroid-Sensitive Nephrotic Syndrome in Children: A Non-Targeted Metabolomic Study. [PDF]

Cells
Kanai T, Ogiso H, Aoyagi J, Kurosaki M, Maru T, Ishii M, Tanimoto K, Yoshino M, Yamashita Y, Tajima T, Nagai R, Aizawa K.   +11 more
europepmc   +1 more source

Circulating Sphingolipids and Incident CKD

Amanda M. Fretts, Paul N. Jensen, Benjamin Lidgard, Colleen M. Sitlani, David S. Siscovick, Irena B. King, Reya H. Mokiao, Andrew N. Hoofnagle, Jason G. Umans, Rozenn N. Lemaître   +9 more
openalex   +1 more source