Results 111 to 120 of about 31,322 (227)

Enterotoxin Production of Bacillus thuringiensis Isolates From Biopesticides, Foods, and Outbreaks

Frontiers in Microbiology, 2018
While the relevance of Bacillus (B.) cereus as a major cause of gastroenteritis is undisputed, the role of the closely related B. thuringiensis in foodborne disease is unclear. B. thuringiensis strains frequently harbor enterotoxin genes.
Sophia Johler, Eva M. Kalbhenn, Nicole Heini, Peter Brodmann, Sylvia Gautsch, Murat Bağcioğlu, Murat Bağcioğlu, Matthias Contzen, Roger Stephan, Monika Ehling-Schulz   +9 more
doaj   +1 more source

Adults With Acid Sphingomyelinase Deficiency Have Sustained Improvements in Clinical Outcomes With up to 5 Years of Olipudase Alfa Enzyme Replacement Therapy: ASCEND Trial Final Results

Journal of Inherited Metabolic Disease, Volume 49, Issue 3, May 2026.
ABSTRACT Acid sphingomyelinase deficiency (ASMD) is a rare debilitating lysosomal storage disease resulting in multisystemic disease manifestations, significant disease burden, and early mortality for some individuals. Enzyme replacement therapy (ERT) with olipudase alfa (Xenpozyme) is the first disease‐specific treatment indicated for noncentral ...
Melissa P. Wasserstein, Carla E. Hollak, Antonio Barbato, Renata C. Gallagher, Roberto Giugliani, Norberto Bernardo Guelbert, Julia B. Hennermann, Takayuki Ikezoe, Robin Lachmann, Olivier Lidove, Paulina Mabe, Eugen Mengel, Maurizio Scarpa, Ebubekir Senates, Michel Tchan, Beth L. Thurberg, Jesus Villarrubia, Nicole M. Armstrong, Shashi Bhushan, Yong Kim, Monica Kumar   +20 more
wiley   +1 more source

Plasma Membrane Lipid Domains as Platforms for Vesicle Biogenesis and Shedding?

Biomolecules, 2018
Extracellular vesicles (EVs) contribute to several pathophysiological processes and appear as emerging targets for disease diagnosis and therapy. However, successful translation from bench to bedside requires deeper understanding of EVs, in particular ...
Hélène Pollet, Louise Conrard, Anne-Sophie Cloos, Donatienne Tyteca   +3 more
doaj   +1 more source

Upregulation of sphingomyelin and ABCA8 in response to TDP‐43 pathology in amyotrophic lateral sclerosis brain

Brain Pathology, Volume 36, Issue 3, May 2026.
Increases in sphingomyelin in response to TDP‐43 pathology in the disease‐affected motor cortex of amyotrophic lateral sclerosis (ALS) brain. Abstract Amyotrophic lateral sclerosis (ALS) is a rapidly progressing neurodegenerative disease characterized by the degeneration of motor neurons and the presence of TAR DNA‐binding protein 43 (TDP‐43 ...
Finula I. Isik, Russell Pickford, Nicolas Dzamko, Kerry‐Anne Rye, Woojin Scott Kim   +4 more
wiley   +1 more source

Apoptosis and signalling in acid sphingomyelinase deficient cells

BMC Cell Biology, 2001
Background Recent evidence suggests that the activation of a non-specific lipid scramblase during apoptosis induces the flipping of sphingomyelin from the cell surface to the cytoplasmic leaftet of the plasma membrane. Inner leaflet sphingomyelin is then
Sillence Dan J
doaj   +1 more source

Identification of miR‐150‐5p in Human Amniotic Membrane Mesenchymal Cell‐Derived Extracellular Vesicles as a Novel Mechanism Driving Cardioprotection

European Journal of Clinical Investigation, Volume 56, Issue 5, May 2026.
Human amniotic membrane mesenchymal stem cells (hAMSCs) provide significant cardioprotection following myocardial ischemia/reperfusion injury. They improve cardiac function and reduce fibrosis by modulating the MIAT/miR‐150‐5p/HOXA4 signalling axis.
Nunzio Alcharani, Laura Tesoro, Javier Díez‐Mata, José Luis Zamorano, Marta Saura, Maite Iglesias, Carlos Zaragoza   +6 more
wiley   +1 more source

The role of membrane lipids in the induction of macrophage apoptosis by microparticles [PDF]

, 2018
Microparticles are membrane-derived vesicles that are released from cells during activation or cell death. These particles can serve as mediators of intercellular cross-talk and induce a variety of cellular responses.
Distler, Jörg, Distler, Oliver, Gay, Renate, Gay, Steffen, Huber, Lars, Jüngel, Astrid, Michel, Beat, Moritz, Falk, Pisetsky, David   +8 more
core  

Structure and Function of Sphingomyelinase

YAKUGAKU ZASSHI, 2009
Bacillus cereus is one that causes of opportunistic human infections. Sphingomyelinase produced by B. cereus is assumed a virulence factor for the infection. Sphingomyelinase from Bacillus cereus (Bc-SMase) is Mg(2+)-containing metalloenzyme. Bc-SMase is a family of neutral SMase (nSMase) and mimics the actions of the endogenous mammalian nSMase in ...
openaire   +3 more sources

Sphingomyelinase treatment of low density lipoprotein and cultured cells results in enhanced processing of LDL which can be modulated by sphingomyelin.

Journal of Lipid Research, 1992
The addition of neutral sphingomyelinase from S. aureus to the medium of rat intestinal epithelial cell cultures (IEC-6) containing added human low density lipoprotein (LDL) resulted in two- to fivefold increases in LDL uptake and degradation.
AK Gupta, H Rudney
doaj   +1 more source

Staphylococcus aureus α-Toxin Induces Inflammatory Cytokines via Lysosomal Acid Sphingomyelinase and Ceramides

Cellular Physiology and Biochemistry, 2017
Background/Aims: Staphylococcus aureus (S. aureus) infections are a major clinical problem and range from mild skin and soft-tissue infections to severe and even lethal infections such as pneumonia, endocarditis, sepsis, osteomyelitis, and toxic shock ...
Jie Ma, Erich Gulbins, Michael J. Edwards, Charles C. Caldwell, Martin Fraunholz, Katrin Anne Becker   +5 more
doaj   +1 more source