Results 191 to 200 of about 31,322 (227)
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Journal of Bioscience and Bioengineering, 2012
A sphingomyelinase C (SMase) was identified in the culture supernatant of Streptomyces sp. A9107 (S-SMase). Although S-SMase seems to be a typical bacterial SMase, the primary structure of S-SMase was unusual for known bacterial SMase. The gene was functionally overexpressed in the culture medium of recombinant Rhodococcus erythropolis.
Takayuki, Sogabe +4 more
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A sphingomyelinase C (SMase) was identified in the culture supernatant of Streptomyces sp. A9107 (S-SMase). Although S-SMase seems to be a typical bacterial SMase, the primary structure of S-SMase was unusual for known bacterial SMase. The gene was functionally overexpressed in the culture medium of recombinant Rhodococcus erythropolis.
Takayuki, Sogabe +4 more
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Interfacial regulation of bacterial sphingomyelinase activity
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1997The objective of this study was to define how the quality of the buffer/membrane interface influences the activity of bacterial sphingomyelinase acting at the interface. The enzyme reaction was carried out in a zero-order trough using a surface barostat.
M, Jungner, H, Ohvo, J P, Slotte
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Sphingomyelin analogues as inhibitors of sphingomyelinase
Bioorganic & Medicinal Chemistry Letters, 2003To search for neutral sphingomyelinase inhibitors we designed and synthesized hydrolytically stable analogues of sphingomyelin. The novel compounds 8 and 9 which were replaced the phosphodiester moiety of sphingomyelin with the carbamate moiety showed inhibitory activity with an IC(50) value of micro M on neutral sphingomyelinase in rat brain ...
Minoru, Taguchi +10 more
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Role of sphingomyelinases in neurological disorders
Expert Opinion on Therapeutic Targets, 2015Sphingomyelinases, which catalyze the hydrolysis of sphingomyelin to ceramide and phosphorylcholine, are abundant in the brain. These enzymes are a major, rapid source of ceramide production not only during physiological responses to receptor stimulation, but also in neurological disorders.We covered an introduction to sphingomyelinases and its ...
Wei-Yi, Ong +4 more
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Functional Inhibitors of Acid Sphingomyelinase (FIASMAs)
2013Sphingolipids are not only structural components of biological membranes, but also play an important role in cellular signalling and, thus, are involved in cell proliferation and differentiation but also stress and cell death. It is therefore of great clinical relevance to define inhibitors of the enzymes involved in sphingolipid metabolism.
Kornhuber, Johannes +3 more
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Advances in lipid research, 1993
Although we have accumulated few data that would definitely designate the role of N-SMase in modern cell biology, current evidence indicates that N-SMase may play a central role in signal transduction (Fig. 7). Biomodulators such as hormones, antibiotics, drugs, growth factors, and lipoproteins may interact with N-SMase either directly or in ...
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Although we have accumulated few data that would definitely designate the role of N-SMase in modern cell biology, current evidence indicates that N-SMase may play a central role in signal transduction (Fig. 7). Biomodulators such as hormones, antibiotics, drugs, growth factors, and lipoproteins may interact with N-SMase either directly or in ...
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STAPHYLOCOCCAL SPHINGOMYELINASE (β‐HEMOLYSIN)*
Annals of the New York Academy of Sciences, 1974A W, Bernheimer, L S, Avigad, K S, Kim
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