Results 171 to 180 of about 23,449 (215)
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Sphingomyelinases in cell regulation
Seminars in Cell & Developmental Biology, 1997Sphingomyelin hydrolysis and ceramide generation have emerged as key events in cellular regulation. Sphingomyelinases (SMases) catalyse the breakdown of sphingomyelin to form ceramide and phosphorylcholine. Ceramide formed through activation of SMases may function as a second messenger in mediating cell growth, differentiation, stress responses, and ...
, Liu, , Obeid, , Hannun
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Chromatofocusing of purified placental sphingomyelinase
Biochimie, 1983To establish the profile of the multiple forms of placental lysosomal sphingomyelinase, we have developed in a preliminary step, a new sequence of purification. This protocol has a good yield such that the final preparation is representative of the whole enzyme. Using chromatofocusing, purified sphingomyelinase is resolved into 4 major forms whose pI's
R, Rousson, M T, Vanier, P, Louisot
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Role of sphingomyelinases in neurological disorders
Expert Opinion on Therapeutic Targets, 2015Sphingomyelinases, which catalyze the hydrolysis of sphingomyelin to ceramide and phosphorylcholine, are abundant in the brain. These enzymes are a major, rapid source of ceramide production not only during physiological responses to receptor stimulation, but also in neurological disorders.We covered an introduction to sphingomyelinases and its ...
Wei-Yi, Ong +4 more
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Sphingomyelinase of Human Tissues
1978Sphingomyelinase (sphingomyelin phosphodiesterase, E.C. 3.1.4. 12) catalyzes hydrolysis of sphingomyelin to ceramide and phosphorylcholine. A genetic deficiency of this enzyme characterizes at least two distinct clinical forms of Niemann-Pick disease (Crocker’s Type A and Type B (1)).
S, Yamaguchi, K, Suzuki
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Magnesium-dependent sphingomyelinase
Biochemical and Biophysical Research Communications, 1976Abstract An enzyme which requires divalent metals and hydrolyses sphingomyelin to ceramide and phosphorylcholine is present in rat and human brain and practically absent from other organs. The greatest activity is associated with the microsomal fraction.
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The Extended Family of Neutral Sphingomyelinases
Biochemistry, 2006The neutral sphingomyelinases (N-SMases) are considered major candidates for mediating the stress-induced production of ceramide, and N-SMase activity has been identified, characterized, and cloned from bacteria, yeast, and mammalian cells. Although the level of identity between these enzymes is low, a number of key residues thought to be involved in ...
Christopher J, Clarke +5 more
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A method for the determination of sphingomyelinase activity
Clinica Chimica Acta, 1975A method is presented for the determination of the activity of sphingomyelinase. It is based on the determination of sphingomyelin before and after enzymatic conversion with the aid of a quantitative paper chromatographic analysis of phospholipids. This method is used for the determination of sphingomyelinase activity in various tissues such as those ...
R E, De Rooij +4 more
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The function of sphingomyelinases in mycobacterial infections
Biological Chemistry, 2018Abstract Tuberculosis (TB), caused by Mycobacterium tuberculosis, is one of the deadliest and most important infectious diseases worldwide. The sphingomyelinase/ceramide system, which has been shown several times to be a crucial factor in the internalization, processing and killing of diverse pathogens, also modulates the pro ...
Wu, Yuqing +2 more
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Sphingomyelin analogues as inhibitors of sphingomyelinase
Bioorganic & Medicinal Chemistry Letters, 2003To search for neutral sphingomyelinase inhibitors we designed and synthesized hydrolytically stable analogues of sphingomyelin. The novel compounds 8 and 9 which were replaced the phosphodiester moiety of sphingomyelin with the carbamate moiety showed inhibitory activity with an IC(50) value of micro M on neutral sphingomyelinase in rat brain ...
Minoru, Taguchi +10 more
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Acid sphingomyelinase in macrophage apoptosis
Current Opinion in Lipidology, 2004This article presents an overview of the recent progress in understanding metabolic and functional interrelationships of biologically active sphingolipids related to the sphingomyelin signal transduction pathway in relation to the regulation of apoptosis in macrophages.Ceramide generation is an essential, early step in apoptosis in numerous systems ...
Urs P, Steinbrecher +2 more
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