Sphingosine-1-phosphate affects myocardial vascular homeostasis by regulating the balance of sphingosine-1-phosphate receptors in the hearts of diabetic mice [PDF]
Journal of International Medical ResearchObjective This study aimed to explore the effect of sphingosine-1-phosphate on vascular homeostasis in the myocardium of diabetic mice. Methods Bioinformatics analyses were performed to analyze the targets and function of sphingosine-1-phosphate in ...
Guozhu Jin +4 more
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The sphingosine‐1‐phosphate signaling pathway (sphingosine‐1‐phosphate and its receptor, sphingosine kinase) and epilepsy [PDF]
Epilepsia OpenEpilepsy is one of the common chronic neurological diseases, affecting more than 70 million people worldwide. The brains of people with epilepsy exhibit a pathological and persistent propensity for recurrent seizures.
Lin Wang +4 more
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Broad and diverse roles of sphingosine-1-phosphate/sphingosine-1-phosphate receptors in the prostate [PDF]
iScienceSummary: Benign prostatic hyperplasia (BPH) is a common condition in aging males, but its underlying pathogenesis remains unclear. Sphingosine-1-phosphate (S1P) and its receptors (S1PRs) play important roles in various diseases, while less studied in ...
Daoquan Liu +12 more
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Small EVs From Adipose‐Derived MSCs Modulate Epidermal Barrier and Inflammation Via Sphingosine‐1‐Phosphate Signaling Pathway [PDF]
Journal of Extracellular VesiclesEpidermal permeability barrier defects are associated with several skin diseases, including atopic dermatitis (AD). Using an AD mouse model, we previously demonstrated that topically administered small extracellular vesicles (sEVs) (prepared following ...
Kyong‐Oh Shin +15 more
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Sphingosine-1-phosphate in the regulation of diabetes mellitus: a scientometric study to an in‐depth review [PDF]
Frontiers in EndocrinologyDiabetes is a significant global health issue, causing extensive morbidity and mortality, and represents a serious threat to human health. Recently, the bioactive lipid molecule Sphingosine-1-Phosphate has garnered considerable attention in the field of ...
Jieying Li +7 more
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Enhancement of neoangiogenesis and follicle survival by sphingosine-1-phosphate in human ovarian tissue xenotransplants. [PDF]
PLoS ONE, 2011 Ovarian transplantation is one of the key approaches to restoring fertility in women who became menopausal as a result of cancer treatments. A major limitation of human ovarian transplants is massive follicular loss during revascularization.
Reza Soleimani +2 more
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ESC Heart Failure, 2023 Aims Therapeutic options targeting post‐ischaemic cardiac remodelling are sparse. The bioactive sphingolipid sphingosine‐1‐phosphate (S1P) reduces ischaemia/reperfusion injury.
Amin Polzin +16 more
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Discover Oncology, 2021 Sphingosine-1-phosphate (S1P), a pleiotropic lipid mediator, participates in various cellular processes during tumorigenesis, including cell proliferation, survival, drug resistance, metastasis, and angiogenesis. S1P is formed by two sphingosine kinases (
Guangmeng Xu +4 more
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Cells, 2020 Sphingosine 1-phosphate (S1P), derived from membrane sphingolipids, is a pleiotropic bioactive lipid mediator capable of evoking complex immune phenomena.
Alexandra Lucaciu +4 more
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Cells, 2023 Psoriasis is a long-lasting skin condition characterized by redness and thick silver scales on the skin’s surface. It involves various skin cells, including keratinocytes, dendritic cells, T lymphocytes, and neutrophils.
Kana Masuda-Kuroki +2 more
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