Results 11 to 20 of about 35,942 (184)
Sphingosine 1-Phosphate in Renal Diseases [PDF]
Cellular Physiology and Biochemistry, 2013 Because of its highly bioactive properties sphingosine 1-phosphate (S1P) is an attractive target for the treatment of several diseases. Since the expression of sphingosine kinases as well as S1P receptors was demonstrated in the kidney, questions about ...
Alexander Koch +2 more
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Circulation Research, 2006 See related article, pages 731–739 A key question in unlocking the mystery of accelerated atherosclerosis that often accompanies types1 and 2 diabetes and leads to increased incidence and severity of heart attacks and strokes is, what are the precise biochemical and molecular signaling pathways that perturb the diabetic blood vessel leading to ...
Ravichandran Ramasamy +2 more
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British Journal of Pharmacology, 2009 Sphingosine-1 phosphate (S1P) is a bioactive sphingolipid that is critical in the development of blood vessels, and in the adult regulates vascular functions including vascular tone, endothelial integrity, and angiogenesis. Further, S1P may regulate arterial lesions in disease and after injury by controlling leukocyte recruitment and smooth muscle cell
G, Daum, A, Grabski, M A, Reidy
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Sphingosine 1-phosphate signalling [PDF]
Development, 2014 Sphingosine 1-phosphate (S1P) is a lipid mediator formed by the metabolism of sphingomyelin. In vertebrates, S1P is secreted into the extracellular environment and signals via G protein-coupled S1P receptors to regulate cell-cell and cell-matrix adhesion, and thereby influence cell migration, differentiation and survival.
Karen, Mendelson +2 more
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Sphingosine 1-Phosphate Signaling at the Skin Barrier Interface
Biology, 2022 Sphingosine 1-phosphate (S1P) is a product of membrane sphingolipid metabolism. S1P is secreted and acts via G-protein-coupled receptors, S1PR1-5, and is involved in diverse cellular functions, including cell proliferation, immune suppression, and ...
Kana Masuda-Kuroki, Anna Di Nardo
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Sphingosine 1-phosphate and cancer [PDF]
Advances in Biological Regulation, 2018 The bioactive lipid, sphingosine 1-phosphate (S1P) is produced by phosphorylation of sphingosine and this is catalysed by two sphingosine kinase isoforms (SK1 and SK2). Here we discuss structural functional aspects of SK1 (which is a dimeric quaternary enzyme) that relate to coordinated coupling of membrane association with phosphorylation of Ser225 in
Nigel J. Pyne +3 more
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Sphingosine 1-Phosphate Receptors and Metabolic Enzymes as Druggable Targets for Brain Diseases
Frontiers in Pharmacology, 2019 The central nervous system is characterized by a high content of sphingolipids and by a high diversity in terms of different structures. Stage- and cell-specific sphingolipid metabolism and expression are crucial for brain development and maintenance ...
Sara Grassi +6 more
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Sphingosine 1-phosphate chemical biology [PDF]
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2008 A dozen years ago, the term 'S1P' (sphingosine 1-phosphate) was not in the lexicons of scientific literature databases. By early 2008, this query term retrieved well over 1000 citations from PubMed - about 225 of these appeared in 2007. Indeed, S1P is arguably the most heavily studied lipid molecule at present.
Kevin R, Lynch, Timothy L, Macdonald
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Sphingosine-1-Phosphate Signaling in Cardiovascular Diseases
Biomolecules, 2023 Sphingosine-1-phosphate (S1P) is an important sphingolipid molecule involved in regulating cardiovascular functions in physiological and pathological conditions by binding and activating the three G protein-coupled receptors (S1PR1, S1PR2, and S1PR3 ...
Na Wang +3 more
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Sphingosine 1-phosphate and inflammation [PDF]
International Immunology, 2019 AbstractAbstractSphingosine 1-phosphate (S1P), a sphingolipid mediator, regulates various cellular functions via high-affinity G protein-coupled receptors, S1P1-5. The S1P-S1P receptor signaling system plays important roles in lymphocyte trafficking and maintenance of vascular integrity, thus contributing to the regulation of complex inflammatory ...
Hideru, Obinata, Timothy, Hla
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