Results 21 to 30 of about 50,070 (158)

Proteolysis of Sars-Associated Coronavirus Spike Glycoprotein [PDF]

, 2006
Severe acute respiratory syndrome-associated coronavirus (SARS-CoV) mediates attachment, receptor engagement and entry via its spike glycoprotein (S). S-dependent viral entry requires the presence of a primary receptor, angiotensin converting enzyme-2 (ACE2), while the C-type lectins, DC-SIGN, DC-SIGNR, and LSECtin act as attachment factors, promoting ...
Simmons, Graham, Rennekamp, Andrew J., Bates, Paul   +2 more
openaire   +2 more sources

Multiple regions of the murine coronavirus spike glycoprotein influence neurovirulence [PDF]

Journal of NeuroVirology, 2001
The spike (S) glycoprotein of mouse hepatitis virus (MHV) is a major determinant of neurovirulence. Using targeted recombination we previously demonstrated that the S gene of the highly neurovirulent MHV-4 conferred a dramatic increase in neurovirulence to the mildly neurovirulent MHV-A59.
Phillips, Joanna J, Chua, MingMing, Seo, Su-hun, Weiss, Susan R   +3 more
openaire   +4 more sources

Vaccine design of coronavirus spike (S) glycoprotein in chicken: immunoinformatics and computational approaches [PDF]

Translational Medicine Communications, 2020
Abstract Background Infectious bronchitis (IB) is a highly contagious respiratory disease in chickens and produces economic loss within the poultry industry. This disease is caused by a single stranded RNA virus belonging to Cronaviridae family.
Eman Ali Awadelkareem, Sumaia Awad Elkariem Ali   +1 more
openaire   +4 more sources

Biochemical Analysis of Coronavirus Spike Glycoprotein Conformational Intermediates during Membrane Fusion [PDF]

Journal of Virology, 2019
Recent studies using single-particle cryo-electron microscopy (cryoEM) revealed the mechanism underlying activation of viral fusion protein at the priming stage. However, characterizing the subsequent triggering stage underpinning transition from pre- to postfusion structures is difficult because single-particle cryoEM excludes unstable structures that
Kawase, Miyuki, Kataoka, Michiyo, Shirato, Kazuya, Matsuyama, Shutoku   +3 more
openaire   +2 more sources

Tectonic conformational changes of a coronavirus spike glycoprotein promote membrane fusion [PDF]

Proceedings of the National Academy of Sciences, 2017
Significance The pandemic potential of coronaviruses was recently demonstrated twice by global outbreaks of deadly pneumonia. The spike (S) glycoprotein initiates infection through conformational changes that remain largely uncharacterized. Here we report the cryoEM structure of an S glycoprotein in the postfusion state, showing large-scale ...
Walls, Alexandra, Tortorici, M. Alejandra, Snijder, Joost, Xiong, Xiaoli, Bosch, Berend-Jan, Rey, Félix A., Veesler, David   +6 more
openaire   +4 more sources

Primary Structures of Hemagglutinin-esterase and Spike Glycoproteins of Murine Coronavirus DVIM [PDF]

Virus Genes, 1998
Diarrhea virus of infant mice (DVIM) is a member of murine hepatitis viruses (MHVs). The nucleotide sequences of the genes encoding the hemagglutinin-esterase (HE) and the spike (S) glycoproteins from DVIM were determined and compared with those of other MHVs.
Morita, Eiji, Ebina, Hirotaka, Muto, Akira, Himeno, Hyouta, Hatakeyama, Koki, Sugiyama, Kazuo   +5 more
openaire   +2 more sources

Receptor binding may directly activate the fusion machinery in coronavirus spike glycoproteins [PDF]

, 2021
AbstractSARS-CoV-2, the causative agent of the COVID-19 pandemic, is an enveloped RNA virus. Trimeric spike glycoproteins extend outward from the virion; these class I viral membrane fusion proteins mediate entry of the virus into a host cell and are the dominant antigen for immune response.
Yuzhang Wang, Lucy Fallon, Lauren Raguette, Stephanie Budhan, Kellon Belfon, Darya Stepanenko, Stephanie Helbock, Sarah Varghese, Carlos Simmerling   +8 more
openaire   +1 more source

Canine respiratory coronavirus employs caveolin-1-mediated pathway for internalization to HRT-18G cells [PDF]

, 2018
Canine respiratory coronavirus (CRCoV), identified in 2003, is a member of the Coronaviridae family. The virus is a betacoronavirus and a close relative of human coronavirus OC43 and bovine coronavirus.
A Milewska, A Pratelli, A Quan, Aleksandra Milewska, AM Zaki, Artur Szczepanski, B Hernaez, B Jancekova, BA Mainou, BJ Dille, C Burkard, C Kooi, C Liu, C Liu, D Dutta, DM Blau, E Dietzel, E Girard, E Hamme Van, EJ Bowman, F Samson, G Preta, GA Wudiri, GM Li, GR Ares, H Imhoff, H Lin, H Wang, IC Huang, IM Mackay, J Li, J Schindelin, J Somsel Rodman, JA Mitchell, JK Millet, JL Wang, JP Lim, JR Henley, Judy A. Mitchell, K Erles, K Erles, K Owczarek, K Shirato, K Shirato, Katarzyna Owczarek, Krzysztof Pyrc, KS Choi, L Kleist von, L Pelkmans, LH Wang, LJ Reed, M Marsh, MG Hemida, MJ Geisow, MJ Vincent, O Achour, O Heikkila, P Duckert, P Eifart, P Oh, Q Xu, R Nomura, S Bertram, S Bolte, S Gierer, S Matsuyama, SL Priestnall, TA Hill, VC Chu, X Ren, Y Inoue, Y Phonphok, Z Qian, Z Qinfen, Zbigniew Baster, Zenon Rajfur   +75 more
core   +8 more sources

COVID-19 and chronological aging : senolytics and other anti-aging drugs for the treatment or prevention of corona virus infection? [PDF]

, 2020
COVID-19, also known as SARS-CoV-2, is a new emerging zoonotic corona virus of the SARS (Severe Acute Respiratory Syndrome) and the MERS (Middle East Respiratory Syndrome) family.
Auwerx, Blagosklonny, Blagosklonny, Blagosklonny, Colasurdo, Colson, Diaz-Quijano, Du, Erusalimsky, Gerontol, Gorospe, Hoffmann, Häkkinen, Jang, Li, Lisanti, Lisanti, Lu, Masternak, Munster, Musso, Nowakowski, Porter, Subbarao, Subbarao, Tanga, Tremblay, Wilce, Yaron, Yusof, Zhang   +30 more
core   +2 more sources

Murine Coronavirus Spike Glycoprotein [PDF]

, 2001
The mature Coronavirus spike is a large, oligomeric, type I integral membrane glycoprotein that projects about 20 nm from the surface of infected cells and virions. In this extracellular position, the spikes function to bind the cellular receptors extending from opposing membranes.
openaire   +2 more sources