Results 31 to 40 of about 50,070 (158)

Immunogenicity of a recombinant coronavirus spike glycoprotein expressed in transgenic plants [PDF]

Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz, 2000
Recently, it has been demonstrated that plants offer the possibility of producing low cost subunit vaccines that can be either parenterally or orally administered. Here we review data we obtained on the immunological response elicited by two recombinant versions of the glycoprotein S from the swine transmissible gastroenteritis coronavirus (TGEV ...
Escribano, J.M., Borca, M.V.
openaire   +1 more source

Bat and pangolin coronavirus spike glycoprotein structures provide insights into SARS-CoV-2 evolution [PDF]

Nature Communications, 2020
AbstractIn recognizing the host cellular receptor and mediating fusion of virus and cell membranes, the spike (S) glycoprotein of coronaviruses is the most critical viral protein for cross-species transmission and infection. Here we determined the cryo-EM structures of the spikes from bat (RaTG13) and pangolin (PCoV_GX) coronaviruses, which are closely
Shuyuan Zhang, Shuyuan Qiao, Jinfang Yu, Jianwei Zeng, Sisi Shan, Jun Lan, Long Tian, Linqi Zhang, Xinquan Wang   +8 more
openaire   +3 more sources

The V5A13.1 envelope glycoprotein deletion mutant of mouse hepatitis virus type-4 is neuroattenuated by its reduced rate of spread in the central nervous system. [PDF]

, 1992
Following intracerebral inoculation of adult Balb/c Byj mice, the MHV-4 strain of mouse hepatitis virus (MHV) had an LD50 of less than 0.1 PFU, whereas its monoclonal antibody resistant variant V5A13.1 had an LD50 of 10(4.2) PFU.
Bloom, F, Buchmeier, MJ, Fazakerley, JK, Parker, SE   +3 more
core   +1 more source

Cytokine release syndrome in COVID-19 patients, a new scenario for an old concern. The fragile balance between infections and autoimmunity [PDF]

, 2020
On 7 January 2020, researchers isolated and sequenced in China from patients with severe pneumonitis a novel coronavirus, then called SARS-CoV-2, which rapidly spread worldwide, becoming a global health emergency.
Diamanti, A. P., Lagana, B., Pioli, C., Rosado, M. M., Sesti, G.   +4 more
core   +2 more sources

In vitro and in vivo expression of foreign genes by transmissible gastroenteritis coronavirus-derived minigenomes [PDF]

, 2002
A helper-dependent expression system based on transmissible gastroenteritis coronavirus (TGEV) has been developed using a minigenome of 3·9 kb (M39).
Alonso, S., Balasch, M., Enjuanes, L., Izeta, A., Moormann, R.J.M., Plana Duran, J., Reimann, I., Sola, I., Teifke, J.P.   +8 more
core   +3 more sources

Cryo-electron Microscopy Structure of the Swine Acute Diarrhea Syndrome Coronavirus Spike Glycoprotein Provides Insights into Evolution of Unique Coronavirus Spike Proteins

Journal of Virology, 2020
In this article, we report the atomic-resolution prefusion structure of the spike protein from swine acute diarrhea syndrome coronavirus (SADS-CoV). SADS-CoV is a pathogenic alphacoronavirus that was responsible for a large-scale outbreak of fatal disease in pigs and that was reported to be capable of interspecies transmission.
Guan, Hongxin, Wang, Youwang, Perčulija, Vanja, Saeed, Abdullah F. U. H., Liu, Yichang, Li, Jinyu, Jan, Syed Sajid, Li, Yu, Zhu, Ping, Ouyang, Songying   +9 more
openaire   +3 more sources

Differential maturation and subcellular localization of severe acute respiratory syndrome coronavirus surface proteins S, M and E [PDF]

, 2005
Post-translational modifications and correct subcellular localization of viral structural proteins are prerequisites for assembly and budding of enveloped viruses. Coronaviruses, like the severe acute respiratory syndrome-associated virus (SARS-CoV), bud
Altmeyer, R, Chan, C, Chu, K, CrescenzoChaigne, B, Escriou, N, Kam, J, Kien, F, Nal, B, Siu, L, Staropoli, I, Tse, J, van der Wef, S, Yuen, KY   +12 more
core   +3 more sources

Demyelination Determinants Map to the Spike Glycoprotein Gene of Coronavirus Mouse Hepatitis Virus [PDF]

Journal of Virology, 2000
ABSTRACTDemyelination is the pathologic hallmark of the human immune-mediated neurologic disease multiple sclerosis, which may be triggered or exacerbated by viral infections. Several experimental animal models have been developed to study the mechanism of virus-induced demyelination, including coronavirus mouse hepatitis virus (MHV) infection in mice.
J, Das Sarma, L, Fu, J C, Tsai, S R, Weiss, E, Lavi   +4 more
openaire   +2 more sources

Structure, receptor recognition, and antigenicity of the human coronavirus CCoV-HuPn-2018 spike glycoprotein

Cell, 2022
The isolation of CCoV-HuPn-2018 from a child respiratory swab indicates that more coronaviruses are spilling over to humans than previously appreciated. We determined the structures of the CCoV-HuPn-2018 spike glycoprotein trimer in two distinct conformational states and showed that its domain 0 recognizes sialosides.
M. Alejandra Tortorici, Alexandra C. Walls, Anshu Joshi, Young-Jun Park, Rachel T. Eguia, Marcos C. Miranda, Elizabeth Kepl, Annie Dosey, Terry Stevens-Ayers, Michael J. Boeckh, Amalio Telenti, Antonio Lanzavecchia, Neil P. King, Davide Corti, Jesse D. Bloom, David Veesler   +15 more
openaire   +2 more sources

Protease inhibitors targeting coronavirus and filovirus entry. [PDF]

, 2015
In order to gain entry into cells, diverse viruses, including Ebola virus, SARS-coronavirus and the emerging MERS-coronavirus, depend on activation of their envelope glycoproteins by host cell proteases.
Agudelo, Juliet, Barnard, Dale, Carrion, Ricardo, Lu, Kai, McKerrow, James H, Nunneley, Jerritt W, Pöhlmann, Stefan, Renslo, Adam R, Simmons, Graham, Vedantham, Punitha, Zhou, Yanchen   +10 more
core   +1 more source