The spindle assembly checkpoint and speciation [PDF]
PeerJ, 2020 A mechanism is proposed by which speciation may occur without the need to postulate geographical isolation of the diverging populations. Closely related species that occupy overlapping or adjacent ecological niches often have an almost identical genome ...
Robert C. Jackson, Hitesh B. Mistry
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PIGN spatiotemporally regulates the spindle assembly checkpoint proteins in leukemia transformation and progression [PDF]
Scientific Reports, 2021 Phosphatidylinositol glycan anchor biosynthesis class N (PIGN) has been linked to the suppression of chromosomal instability. The spindle assembly checkpoint complex is responsible for proper chromosome segregation during mitosis to prevent chromosomal ...
Emmanuel K. Teye +9 more
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The chromosomal passenger complex and the spindle assembly checkpoint: kinetochore-microtubule error correction and beyond [PDF]
Cell Division, 2008 During mitosis, correct bipolar chromosome attachment to the mitotic spindle is an essential prerequisite for the equal segregation of chromosomes. The spindle assembly checkpoint can prevent chromosome segregation as long as not all chromosome pairs ...
Maia André F +2 more
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Knl1 participates in spindle assembly checkpoint signaling in maize. [PDF]
Proc Natl Acad Sci U S A, 2021 Significance The spindle assembly checkpoint (SAC) signaling controls the attachments of kinetochores to spindle microtubules rigorously. However, how SAC proteins connect to the kinetochores is largely unknown in plants.
Su H +9 more
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Age-dependent integrity of the meiotic spindle assembly checkpoint in females requires Aurora kinase B. [PDF]
Aging Cell, 2021 A hallmark of advanced maternal age is a significant increase in meiotic chromosome segregation errors, resulting in early miscarriages and congenital disorders. These errors most frequently occur during meiosis I (MI).
Blengini CS +3 more
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Ubc1 turnover contributes to the spindle assembly checkpoint in Saccharomyces cerevisiae [PDF]
G3: Genes, Genomes, Genetics, 2021 The spindle assembly checkpoint protects the integrity of the genome by ensuring that chromosomes are properly attached to the mitotic spindle before they are segregated during anaphase.
Heather E Arsenault +8 more
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Spindle assembly checkpoint-dependent mitotic delay is required for cell division in absence of centrosomes [PDF]
eLifeThe spindle assembly checkpoint (SAC) temporally regulates mitosis by preventing progression from metaphase to anaphase until all chromosomes are correctly attached to the mitotic spindle.
KC Farrell, Jennifer T Wang, Tim Stearns
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JAK2-CHK2 signaling safeguards the integrity of the mitotic spindle assembly checkpoint and genome stability [PDF]
Cell Death and Disease, 2022 Checkpoint kinase 2 (CHK2) plays an important role in safeguarding the mitotic progression, specifically the spindle assembly, though the mechanism of regulation remains poorly understood.
Md Al Nayem Chowdhury +5 more
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Nature Communications, 2019 During the spindle assembly checkpoint, the activity of the anaphase promoting complex/cyclosome (APC/C) is repressed, yet cyclin A2 evades the checkpoint and is targeted for degradation.
Suyang Zhang +2 more
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bir1 deletion causes malfunction of the spindle assembly checkpoint and apoptosis in yeast [PDF]
Frontiers in Oncology, 2012 Cell division in yeast is a highly regulated and well studied event. Various checkpoints are placed throughout the cell cycle to ensure faithful segregation of sister chromatids.
Qun eRen +5 more
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