Results 1 to 10 of about 17,463 (177)
Spindle assembly checkpoint protein dynamics reveal conserved and unsuspected roles in plant cell division. [PDF]
PLoS ONE, 2009 BACKGROUND: In eukaryotes, the spindle assembly checkpoint (SAC) ensures that chromosomes undergoing mitosis do not segregate until they are properly attached to the microtubules of the spindle.
Marie-Cécile Caillaud +9 more
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PLoS ONE, 2010 Microtubule-targeting drugs induce mitotic delay at pro-metaphase by preventing the spindle assembly checkpoint to be satisfied. However, especially after prolonged treatments, cells can escape this arrest in a process called mitotic slippage.
Ana Lúcia Mena +2 more
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Some assembly required: Redefining the mitotic checkpoint
Molecular & Cellular Oncology, 2017 The spindle assembly checkpoint (also known as the spindle or mitotic checkpoint) is a surveillance system that ensures fidelity of chromosome segregation.
John C. Meadows, Jonathan B. A. Millar
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Kinetochore stretching inactivates the spindle assembly checkpoint [PDF]
Journal of Cell Biology, 2009 The spindle assembly checkpoint (SAC) monitors the attachment of microtubules to the kinetochore and inhibits anaphase when microtubule binding is incomplete. The SAC might also respond to tension; however, how cells can sense tension and whether its detection is important to satisfy the SAC remain controversial.
Uchida, Kazuhiko S.K. +5 more
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TRIP13 Regulates Both the Activation and Inactivation of the Spindle-Assembly Checkpoint
Cell Reports, 2016 Summary: Biochemical studies have indicated that p31comet and TRIP13 are critical for inactivating MAD2. To address unequivocally whether p31comet and TRIP13 are required for mitotic exit at the cellular level, their genes were ablated either ...
Hoi Tang Ma, Randy Yat Choi Poon
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Spindle assembly checkpoint: the third decade [PDF]
Philosophical Transactions of the Royal Society B: Biological Sciences, 2011 The spindle assembly checkpoint controls cell cycle progression during mitosis, synchronizing it with the attachment of chromosomes to spindle microtubules. After the discovery of themitotic arrest deficient(MAD) andbudding uninhibited by benzymidazole(BUB) genes as crucial checkpoint components in 1991, the second decade of checkpoint studies (2001 ...
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Noise resistance in the spindle assembly checkpoint [PDF]
Molecular Systems Biology, 2006 Genetically identical cells vary in the amount of expressed proteins even when growing under the same conditions. It is not yet clear how cellular information processing copes with such stochastic fluctuations in protein levels. Here we examine the capacity of the spindle assembly checkpoint to buffer temporal fluctuations in the expression of Cdc20, a
Doncic, Andreas +2 more
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MAP kinase meets mitosis: A role for Raf Kinase Inhibitory Protein in spindle checkpoint regulation
Cell Division, 2007 Raf Kinase Inhibitory Protein (RKIP) is an evolutionarily conserved protein that functions as a modulator of signaling by the MAP kinase cascade.
Rosner Marsha
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Requirement for proteolysis in spindle assembly checkpoint silencing [PDF]
Cell Cycle, 2010 Anaphase initiation requires ubiquitin-dependent proteolysis of crucial substrates through activation of the ubiquitin ligase Anaphase promoting Complex/Cyclosome (ApC/C) in association with its coactivator Cdc20. To prevent chromosome segregation errors, effector proteins of a safeguard mechanism called spindle assembly checkpoint (SAC), Mad2 and ...
Visconti R. +2 more
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TRIP13 is a protein-remodeling AAA+ ATPase that catalyzes MAD2 conformation switching
eLife, 2015 The AAA+ family ATPase TRIP13 is a key regulator of meiotic recombination and the spindle assembly checkpoint, acting on signaling proteins of the conserved HORMA domain family.
Qiaozhen Ye +5 more
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