Results 101 to 110 of about 50,149 (285)
Synchronization and spindle oscillation in noisy integrate-and-fire-or-burst neurons with inhibitory coupling [PDF]
, 2005 We propose another integrate-and-fire model as a single neuron model. We study a globally coupled noisy integrate-and-fire model with inhibitory interaction using the Fokker-Planck equation and the Langevin equation, and find a reentrant transition of oscillatory states.
arxiv +1 more source
ULK1 phosphorylates Mad1 to regulate spindle assembly checkpoint
Nucleic Acids Research, 2019 The spindle assembly checkpoint (SAC) ensures the fidelity of chromosome segregation during mitosis. Here, we show that ULK1, a serine/threonine kinase that plays a key role in initiation of autophagy, also has an important function in the activation of ...
Fengjie Yuan +9 more
semanticscholar +1 more source
Advanced Science, EarlyView.This study reveals that cytoplasmic PABPN1 is essential for mouse oocyte meiotic maturation by coordinating polyadenylation, translation, and degradation of maternal mRNAs. Pabpn1 knockout disrupts CDK1 activation, spindle formation, and chromosome alignment by impairing maturation‐promoting factor (MPF) regulation and BTG4‐mediated deadenylation ...
Xing‐Xing Dai +8 more
wiley +1 more source
Bub1 positions Mad1 close to KNL1 MELT repeats to promote checkpoint signalling
Nature Communications, 2017 The spindle assembly checkpoint ensures correct chromosome segregation and relies on kinetochore localization of the Bub1 and Mad1/Mad2 checkpoint proteins.
Gang Zhang +7 more
doaj +1 more source
USP49 deubiquitinase regulates the mitotic spindle checkpoint and prevents aneuploidy
Cell Death and Disease, 2023 The spindle assembly checkpoint (SAC) is an essential mechanism that ensures the accurate chromosome segregation during mitosis, thus preventing genomic instability.
Diana Campos-Iglesias +7 more
doaj +1 more source
The current view for the silencing of the spindle assembly checkpoint [PDF]
Cell Cycle, 2014 Chromosome bipolar attachment is achieved when sister kinetochores are attached by microtubules emanating from opposite spindle poles, and this process is essential for faithful chromosome segregation during anaphase. A fundamental question in cell biology is how cells ensure that chromosome segregation only occurs after bipolar attachment.
Yanchang Wang +3 more
openaire +3 more sources
Journal of Cell Science, 2018 During the prometaphase stage of mitosis, the cell builds a bipolar spindle of microtubules that mechanically segregates sister chromatids between two daughter cells in anaphase.
Thibault Courthéoux +5 more
semanticscholar +1 more source
BMEMat, EarlyView.This review highlights the complex roles of cellular senescence in cancer progression and suppression, discusses the mechanisms and regulatory pathways involved, and evaluates the efficacy of the “One‐Two punch” sequential treatment approach while addressing emerging challenges in this novel therapeutic strategy.
Qiuming Pan +12 more
wiley +1 more source
The Spindle Assembly Checkpoint Is Required for Hematopoietic Progenitor Cell Engraftment
Stem Cell Reports, 2017 Summary: The spindle assembly checkpoint plays a pivotal role in preventing aneuploidy and transformation. Many studies demonstrate impairment of this checkpoint in cancer cells.
Andreas Brown +9 more
doaj
The Spindle Assembly Checkpoint Functions during Early Development in Non-Chordate Embryos
bioRxiv, 2019 In eukaryotic cells, a spindle assembly checkpoint (SAC) ensures accurate chromosome segregation. This control mechanism monitors proper attachment of chromosomes to spindle microtubules and delays mitotic progression if connections are erroneous or ...
J. Chenevert +8 more
semanticscholar +1 more source