Results 121 to 130 of about 36,497 (260)

Liquid–Liquid Phase Separation in Major Hallmarks of Cancer

Cell Proliferation, Volume 59, Issue 2, February 2026.
Aberrant condensates formed through phase separation are involved in the dysregulation of various critical cellular processes, including genome stability, transcriptional regulation and signal transduction, thereby promoting malignant transformation and the acquisition of multiple cancer hallmarks.
Chen‐chen Xie, Ting Wang, Xin‐ran Liu, Yan Wang, Qin Dang, Tian Ding, Jia‐qi Xu, Xian‐jun Yu, Hai Lin, Xiao‐wu Xu, Yi Qin   +10 more
wiley   +1 more source

Interplay of kinetochores and catalysts drives rapid assembly of the mitotic checkpoint complex

Nature Communications
The spindle assembly checkpoint (SAC) ensures mitotic exit occurs only after sister chromatid biorientation, but how this coordination is mechanistically achieved remains unclear.
Suruchi Sethi, Sabrina Ghetti, Verena Cmentowski, Teresa Benedetta Guerriere, Patricia Stege, Valentina Piano, Andrea Musacchio   +6 more
doaj   +1 more source

Centriole assembly and the role of Mps1: defensible or dispensable?

Cell Division, 2011
The Mps1 protein kinase is an intriguing and controversial player in centriole assembly. Originally shown to control duplication of the budding yeast spindle pole body, Mps1 is present in eukaryotes from yeast to humans, the nematode C.
Fisk Harold A, Pike Amanda N
doaj   +1 more source

Table S2 from Spindle Assembly Checkpoint Inhibition Can Resensitize p53-Null Stem Cells to Cancer Chemotherapy

, 2023
Changlong Liu, Carolyn E. Banister, Phillip Buckhaults   +2 more
openalex   +1 more source

Chromosome Segregation Is Biased by Kinetochore Size [PDF]

, 2018
Chromosome missegregation during mitosis or meiosis is a hallmark of cancer and the main cause of prenatal death in humans. The gain or loss of specific chromosomes is thought to be random, with cell viability being essentially determined by selection ...
Aguiar, P, Almeida, A C, Damas, J, Drpic, D, Khodjakov, A, Larkin, D M, Lewin, H A, Maiato, H, Renda, F   +8 more
core   +2 more sources

Positive Feedback Keeps Duration of Mitosis Temporally Insulated from Upstream Cell-Cycle Events [PDF]

, 2016
Cell division is characterized by a sequence of events by which a cell gives rise to two daughter cells. Quantitative measurements of cell-cycle dynamics in single cells showed that despite variability in G1-, S-, and G2 phases, duration of mitosis is ...
Araujo, AR, Gelens, L, Santos, S, Sheriff, RSM   +3 more
core   +1 more source

Selective vulnerability of aneuploid human cancer cells to inhibition of the spindle assembly checkpoint [PDF]

, 2020
Yael Cohen‐Sharir, James M. McFarland, Mai Abdusamad, Carolyn Marquis, Helen Tang, Marica Rosaria Ippolito, Sara V. Bernhard, Kathrin Laue, Heidi L.H. Malaby, Andrew Jones, Mariya Kazachkova, Nicholas Lyons, Ankur K. Nagaraja, Adam J. Bass, Rameen Beroukhim, Stefano Santaguida, Jason Stumpff, Todd R. Golub, Zuzana Štorchová, Uri Ben‐David   +19 more
openalex   +1 more source

Condensin II is required for efficient Spindle Assembly Checkpoint activation in Drosophila male meiosis [PDF]

, 2022
Cíntia Horta, Alexandra Tavares, Raquel A. Oliveira   +2 more
openalex   +1 more source

The spindle assembly checkpoint is a therapeutic vulnerability of CDK4/6 inhibitor-resistant ER+ breast cancer with mitotic aberrations

, 2022
Isabel Soria‐Bretones, Kelsie L. Thu, Jennifer Silvester, Jennifer Cruickshank, Samah El Ghamrasni, Wail Ba-Alawi, Graham C. Fletcher, Reza Kiarash, Mitchell J. Elliott, Jordan J. Chalmers, Andrea C. Elia, Albert Cheng, April A. N. Rose, Mark R. Bray, Benjamin Haibe‐Kains, Tak W. Mak, David W. Cescon   +16 more
openalex   +1 more source

The RZZ Complex and the Spindle Assembly Checkpoint

Cell Structure and Function, 2009
The conserved protein Rod is found in various organisms. It is localized on the kinetochores or spindle microtubules during cell division. Rod is required for proper chromosome segregation during both mitosis and meiosis. The effects of rod mutations are similar for both equational and reductional divisions, giving rise to anaphases with lagging ...
Yujian, Lu, Zhenyu, Wang, Liang, Ge, Ni, Chen, Heng, Liu   +4 more
openaire   +3 more sources