Results 121 to 130 of about 50,149 (285)

Nanomaterials for acute myeloid leukemia therapy: Current progress and future perspectives

Interdisciplinary Medicine, EarlyView.
Infographics of this review introducing the current treatment strategies, types of nanomaterials, and their advantages in AML treatment (Created with BioRender.com, a license purchased, accessed on March 26, 2024). Abstract Acute myeloid leukemia (AML) is a highly aggressive hematologic malignancy characterized by poor prognosis, high relapse rates ...
Jiarui Zhao, Jiaqi Cui, Lixuan Wang, Xinyi Shi, Jiayan Ding, Muhammad Farhan Sohail, Irshad Hussain, Qihui Liu, Fangfang Chen   +8 more
wiley   +1 more source

TRIP13 Regulates Both the Activation and Inactivation of the Spindle-Assembly Checkpoint

Cell Reports, 2016
Summary: Biochemical studies have indicated that p31comet and TRIP13 are critical for inactivating MAD2. To address unequivocally whether p31comet and TRIP13 are required for mitotic exit at the cellular level, their genes were ablated either ...
Hoi Tang Ma, Randy Yat Choi Poon
doaj  

Smurf2 as a novel mitotic regulator: From the spindle assembly checkpoint to tumorigenesis

Cell Division, 2009
The execution of the mitotic program with high fidelity is dependent upon precise spatiotemporal regulation of posttranslational protein modifications.
Moore Finola E, Ray Dipankar, Osmundson Evan C, Kiyokawa Hiroaki   +3 more
doaj   +1 more source

A fast platform for simulating flexible fiber suspensions applied to cell mechanics [PDF]

, 2016
We present a novel platform for the large-scale simulation of fibrous structures immersed in a Stokesian fluid and evolving under confinement or in free-space. One of the main motivations for this work is to study the dynamics of fiber assemblies within biological cells.
arxiv   +1 more source

Go for Gold: Development of a Scalable Synthesis of [1‐(Ethoxycarbonyl)cyclopropyl] Triphenylphosphonium Tetrafluoroborate, a Key Reagent to Explore Covalent Monopolar Spindle 1 Inhibitors

ChemistryOpen, EarlyView.
[1‐(Ethoxycarbonyl)cyclopropyl] triphenylphosphonium tetrafluoroborate is a limiting key reagent for synthesis of the tricyclic 5,6‐dihydropyrimido[5,4‐e]indolizine and related scaffolds, which are central to First‐in‐Class covalent inhibitors of the protein kinase monopolar spindle 1/threonine tyrosine kinase (TTK).
Leon Rebhan, Rebekka Fürst, Dieter Schollmeyer, Ricardo A. M. Serafim, Matthias Gehringer   +4 more
wiley   +1 more source

Spatial-Temporal Regulation of Spindle Assembly Checkpoint [PDF]

Biophysical Journal, 2013
During mitosis, microtubule spindle organized by the two spindle poles (SP) need to properly capture and align chromosomes at the cell equator to ensure faithful chromosome segregation. Improper chromosome-spindle attachment will activate spindle assembly checkpoint proteins (SAC) emanated from this chromosome.
Jian Liu, Jing Chen
openaire   +2 more sources

Centriole assembly and the role of Mps1: defensible or dispensable?

Cell Division, 2011
The Mps1 protein kinase is an intriguing and controversial player in centriole assembly. Originally shown to control duplication of the budding yeast spindle pole body, Mps1 is present in eukaryotes from yeast to humans, the nematode C.
Fisk Harold A, Pike Amanda N
doaj   +1 more source

Deregulation of the spindle assembly checkpoint is associated with paclitaxel resistance in ovarian cancer

Journal of Ovarian Research, 2018
BackgroundOvarian cancer is the leading gynecologic cancer diagnosed in North America and because related symptoms are not disease specific, this often leads to late detection, an advanced disease state, and the need for chemotherapy.
Taryne M. Chong, A. Sarac, C. Yao, L. Liao, N. Lyttle, P. Boutros, J. Bartlett, M. Spears   +7 more
semanticscholar   +1 more source

Strong Signatures of Selection on Candidate Genes Underlying Core Speciation Mechanisms in Desert Tortoises

Molecular Ecology Resources, EarlyView.
ABSTRACT Genomic incompatibilities and differential ecological adaptation are thought to be fundamental mechanisms of speciation. In this study, we generated a chromosome‐scale reference genome and annotation for Gopherus morafkai , the Sonoran Desert tortoise, and conducted a detailed analysis of genes under positive selection with its sister species,
Sarah M. Baty, Raúl Araya‐Donoso, Avery Paulsen, Avery Williams, Dale F. DeNardo, Kenro Kusumi, Greer A. Dolby   +6 more
wiley   +1 more source

Deletion of the MAD2L1 spindle assembly checkpoint gene is tolerated in mouse models of acute T-cell lymphoma and hepatocellular carcinoma

eLife, 2017
Chromosome instability (CIN) is deleterious to normal cells because of the burden of aneuploidy. However, most human solid tumors have an abnormal karyotype implying that gain and loss of chromosomes by cancer cells confers a selective advantage. CIN can
F. Foijer, L. Albacker, B. Bakker, D. Spierings, Y. Yue, Stephanie Z. Xie, Stephanie H. Davis, Annegret Lutum-Jehle, D. Takemoto, B. Hare, Brinley F Furey, R. Bronson, P. Lansdorp, A. Bradley, P. Sorger   +14 more
semanticscholar   +1 more source