Results 131 to 140 of about 50,149 (285)

Targeting ATF6α Attenuates UVB‐Induced Senescence and Improves Skin Homeostasis by Regulating IL8 Expression

Aging Cell, EarlyView.
UVB exposure can trigger senescence in dermal fibroblasts. We show that silencing ATF6α disrupts the establishment of the UVB‐induced senescent phenotype by preventing the onset of several senescent biomarkers and altering the composition of the SASP, consequently affecting its impact on the skin microenvironment.
Joëlle Giroud, Pauline Delvaux, Laura Carlier, Clémentine De Schutter, Nathalie Martin, Raphaël Rouget, Ayeh Bolouki, Valérie De Glas, Inès Bouriez, Florent Bourdoux, Sophie Burteau, Julien Théry, Gauthier Decanter, Nicolas Penel, Yvan de Launoit, Benjamin Ledoux, Corinne Abbadie, Yves Poumay, Olivier Pluquet, Florence Debacq‐Chainiaux   +19 more
wiley   +1 more source

Human kinetochores are swivel joints that mediate microtubule attachments

eLife, 2016
Chromosome segregation is a mechanical process that requires assembly of the mitotic spindle – a dynamic microtubule-based force-generating machine.
Chris A Smith, Andrew D McAinsh, Nigel J Burroughs   +2 more
doaj   +1 more source

Plk1 bound to Bub1 contributes to spindle assembly checkpoint activity during mitosis

Scientific Reports, 2017
For faithful chromosome segregation, the formation of stable kinetochore–microtubule attachment and its monitoring by the spindle assembly checkpoint (SAC) are coordinately regulated by mechanisms that are currently ill-defined.
Masanori Ikeda, Kozo Tanaka
semanticscholar   +1 more source

CEP162: A critical regulator of ciliary transition zone assembly and its implications in ciliopathies

Journal of Cell Communication and Signaling, Volume 19, Issue 2, June 2025.
Abstract CEP162, a 162‐kDa centrosome protein, is a crucial centrosomal adapter, mediating cell differentiation and polarization. CEP162 maintains mitosis by dynamically stabilizing microtubules. CEP162 promotes the transition zone (TZ) assembly in the basal body through interaction with CEP131, CEP290, and axoneme microtubules as well as the distal ...
Jun Yin, Jialian Bai, Xiaochong He, Wenjuan He, Hongming Miao, Mengjie Zhang, Zhongying Yu, Bing Ni   +7 more
wiley   +1 more source

Causes and consequences of maternal age-related aneuploidy in oocytes: a review

Veterinární Medicína, 2013
Although a positive correlation between aneuploidy and maternal age was first reported almost a century ago, the underlying mechanisms remain mostly unknown.
A. Danylevska, J. Sebestova
doaj   +1 more source

Superfast collective motion of magnetic particles [PDF]

arXiv, 2019
It is well-known that magnetic forces can induce a formation of densely packed strings of magnetic particles or even sheafs of several strings (spindles). Here we show that in a sufficiently strong magnetic field, more complex aggregates of particles, translating with a much faster speed than would be for a single particle or even a spindle, can be ...
arxiv  

Exploration of histone protein γ‐H2AX as a prognostic factor in soft tissue sarcomas and its association with biological behavior, immune cell environment and survival in leiomyosarcoma

International Journal of Cancer, Volume 156, Issue 11, Page 2237-2250, 1 June 2025.
What's new? The remarkably poor prognosis of metastasized soft tissue sarcoma (STS) has motivated a search for novel biomarkers and therapeutic approaches. A promising candidate biomarker is H2A histone family member X (H2AX), a key player in DNA damage detection and repair pathways.
Adrian Georg Simon, Su Ir Lyu, Anne Maria Schultheis, David Stahl, Nora Wuerdemann, Sebastian Walter, Lena Hieggelke, Reinhard Buettner, Christiane Josephine Bruns, Peer Eysel, Lars Mortimer Schiffmann, Karl Knipper, Peter Mallmann, Alexander Quaas, Roland Ullrich   +14 more
wiley   +1 more source

Elevated KIF2C Expression Drives Osteosarcoma Progression by Modulating the Wnt/β‐Catenin Signaling Pathway and Contributing to an Immunosuppressive Tumor Microenvironment

Cancer Medicine, Volume 14, Issue 9, May 2025.
ABSTRACT Background Although kinesin family member 2C (KIF2C) is implicated in various cancers, its role in osteosarcoma (OS) and the associated inflammatory microenvironment remains unclear. Methods Publicly available datasets were analyzed to determine KIF2C expression, diagnostic value, and prognostic relevance in OS. In vitro (proliferation, colony
Ya‐Yun Liu, Wu Sun, Lin Liu, Jin‐Hui Cheng, Jing‐Tang Li, Zu‐Tai Huang, Min Ouyang   +6 more
wiley   +1 more source

Centrosome and spindle assembly checkpoint loss leads to neural apoptosis and reduced brain size

Journal of Cell Biology, 2017
Accurate mitotic spindle assembly is critical for mitotic fidelity and organismal development. Multiple processes coordinate spindle assembly and chromosome segregation.
J. Poulton, J. Cuningham, M. Peifer
semanticscholar   +1 more source

Multi‐Omic Evaluation of PLK1 Inhibitor—Onvansertib—In Colorectal Cancer Spheroids

Journal of Mass Spectrometry, Volume 60, Issue 5, May 2025.
ABSTRACT Polo‐like kinase 1 (Plk1) is a serine/threonine kinase involved in regulating the cell cycle. It is activated by aurora kinase B along with the cofactors Borealin, INCE, and survivin. Plk1 is involved in the development of resistances to chemotherapeutics such as doxorubicin, Taxol, and gemcitabine.
Brian D. Fries, Emily R. Sekera, Joseph H. Holbrook, Amanda B. Hummon   +3 more
wiley   +1 more source