Causes and consequences of maternal age-related aneuploidy in oocytes: a review
Veterinární Medicína, 2013 Although a positive correlation between aneuploidy and maternal age was first reported almost a century ago, the underlying mechanisms remain mostly unknown.
A. Danylevska, J. Sebestova
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6,7-Dimethoxy-3-(3-methoxyphenyl)isoquinolin-1-amine induces mitotic arrest and apoptotic cell death through the activation of spindle assembly checkpoint in human cervical cancer cells [PDF]
, 2013 Kyung‐Sook Chung +6 more
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The Spindle-Assembly Checkpoint, Aneuploidy, and Gastrointestinal Cancer [PDF]
New England Journal of Medicine, 2010 Genomic instability is a common occurrence in solid tumors, and it has long been conjectured that this process plays a causal role in cancer. The field of human molecular genetics has provided a means to test this hypothesis, fueled in part by the analysis of hereditary cancer-predisposition syndromes. Some of the first unequivocal support for the idea
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Proteome of oocyte spindle identifies Ccdc69 regulates spindle assembly like “band-tightening spell”
Cellular and Molecular Life SciencesMeiotic spindle is an intricate structure and required for chromosome segregation and the proper meiotic progression during oocyte maturation, and its function is regulated by a complex network of proteins located at spindle and its peripheral region ...
Jia-Ni Guo +12 more
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Spindle assembly checkpoint acquisition at the mid-blastula transition.
PLoS ONE, 2015 The spindle assembly checkpoint (SAC) maintains the fidelity of chromosome segregation during mitosis. Nonpathogenic cells lacking the SAC are typically only found in cleavage stage metazoan embryos, which do not acquire functional checkpoints until the ...
Maomao Zhang +2 more
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Advanced ScienceAs a major component of the cytoskeleton, intermediate filaments are generally considered to play a supporting role in mitotic cells. They also take part in the regulation of cell motility, proliferation, differentiation, and apoptosis.
Yu Li, Zihao Zhang, Yu Zhang, Bo Xiong
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A pivot-tether model for nucleosome recognition by the chromosomal passenger complex
EMBO ReportsSpatial restriction of Aurora B to T3-phosphorylated histone H3 (H3pT3) nucleosomes adjacent to centromeres during prometaphase and metaphase enables it to phosphorylate proteins necessary for spindle assembly checkpoint signalling and biorientation of ...
Reinis R Ruza +6 more
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Delayed Signaling in Mitotic Checkpoints: Biological Mechanisms and Modeling Perspectives
BiologyTime delays are intrinsic to mitotic regulation, particularly within the spindle assembly checkpoint (SAC) and the spindle position checkpoint (SPOC).
Bashar Ibrahim
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The yeast nuclear pore complex functionally interacts with components of the spindle assembly checkpoint [PDF]
, 2002 Tatiana Iouk +4 more
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