Results 141 to 150 of about 50,149 (285)
Proteomic Dissection of the Spindle Assembly Checkpoint
The FASEB Journal, 2019 Human cell division is a critical process that ensures the accurate transmission of the genetic material from one mother cell to two cells. The mitotic Spindle Assembly Checkpoint (SAC) ensures the fidelity of this process by responding to errors in microtubule‐kinetochore attachment and tension, and arresting the cells in prometaphase to allow time to
Julian P. Whitelegge +4 more
openaire +1 more source
Fin1-PP1 Helps Clear Spindle Assembly Checkpoint Protein Bub1 from Kinetochores in Anaphase
Cell Reports, 2016 Summary: The spindle assembly checkpoint (SAC) monitors chromosome attachment defects, and the assembly of SAC proteins at kinetochores is essential for its activation, but the SAC disassembly process remains unknown.
Michael Bokros +4 more
doaj
Histopathology, Volume 86, Issue 6, Page 916-932, May 2025.This study investigates threonine and tyrosine kinase (TTK) expression in pre‐ and post‐neoadjuvant chemotherapy breast cancer patients. TTK mRNA expression was elevated in breast cancer tissues, predicting reduced survival. Notably, TTK protein expression in neoadjuvant chemotherapy‐treated breast cancer patients was up‐regulated post‐therapy and ...
Abrar Ashi +5 more
wiley +1 more source
Spindle assembly checkpoint acquisition at the mid-blastula transition.
PLoS ONE, 2015 The spindle assembly checkpoint (SAC) maintains the fidelity of chromosome segregation during mitosis. Nonpathogenic cells lacking the SAC are typically only found in cleavage stage metazoan embryos, which do not acquire functional checkpoints until the ...
Maomao Zhang +2 more
doaj +1 more source
Hydrodynamic mechanism for stable spindle positioning in meiosis II oocytes [PDF]
PRX Life 2, 043003 (2024)Cytoplasmic streaming, the persistent flow of fluid inside a cell, induces intracellular transport, which plays a key role in fundamental biological processes. In meiosis II mouse oocytes (developing egg cells) awaiting fertilisation, the spindle, which is the protein structure responsible for dividing genetic material in a cell, must maintain its ...
arxiv +1 more source
Oncogene, 2017 Malignant mesothelioma (MM) is an aggressive malignancy, highly resistant to current medical and surgical therapies, whose tumor cells characteristically show a high level of aneuploidy and genomic instability.
Agata Szymiczek +11 more
semanticscholar +1 more source
A Human REV7 Homolog That Interacts with the Polymerase ζ Catalytic Subunit hREV3 and the Spindle Assembly Checkpoint Protein hMAD2 [PDF]
, 2000 Yoshiki Murakumo +6 more
openalex +1 more source
The Spindle-Assembly Checkpoint, Aneuploidy, and Gastrointestinal Cancer [PDF]
New England Journal of Medicine, 2010 Genomic instability is a common occurrence in solid tumors, and it has long been conjectured that this process plays a causal role in cancer. The field of human molecular genetics has provided a means to test this hypothesis, fueled in part by the analysis of hereditary cancer-predisposition syndromes. Some of the first unequivocal support for the idea
openaire +3 more sources
Association Between Spindle Assembly Checkpoint Gene Expression and Maternal Age in Human Oocytes [PDF]
, 2000 Nury Steuerwald +5 more
openalex +1 more source
Responding to chromosomal breakage during M-phase: insights from a cell-free system
Cell Division, 2009 DNA double strand breaks (DSBs) activate ATM and ATR dependent checkpoints that prevent the onset of mitosis. However, how cells react to DSBs occurring when they are already in mitosis is poorly understood.
Costanzo Vincenzo, Smith Eloise
doaj +1 more source