Results 11 to 20 of about 50,149 (285)
Spindle assembly checkpoint activation and silencing at kinetochores. [PDF]
Semin Cell Dev Biol, 2021 The spindle assembly checkpoint (SAC) is a surveillance mechanism that promotes accurate chromosome segregation in mitosis. The checkpoint senses the attachment state of kinetochores, the proteinaceous structures that assemble onto chromosomes in mitosis in order to mediate their interaction with spindle microtubules.
Lara-Gonzalez P, Pines J, Desai A.
europepmc +6 more sources
Reverse engineering of the spindle assembly checkpoint. [PDF]
PLoS ONE, 2009 The Spindle Assembly Checkpoint (SAC) is an intracellular mechanism that ensures proper chromosome segregation. By inhibiting Cdc20, a co-factor of the Anaphase Promoting Complex (APC), the checkpoint arrests the cell cycle until all chromosomes are ...
Andreas Doncic +3 more
doaj +5 more sources
Complex Commingling: Nucleoporins and the Spindle Assembly Checkpoint [PDF]
Cells, 2015 The segregation of the chromosomes during mitosis is an important process, in which the replicated DNA content is properly allocated into two daughter cells.
Ikram Mossaid, Birthe Fahrenkrog
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Deficient spindle assembly checkpoint in multiple myeloma.
PLoS ONE, 2011 Multiple myeloma (MM) is a hematological disease characterized by an abnormal accumulation of plasma cells in the bone marrow. These cells have frequent cytogenetic abnormalities including translocations of the immunoglobulin heavy chain gene and ...
Elena Díaz-Rodríguez +7 more
doaj +6 more sources
Kinesin KIF15 regulates tubulin acetylation and spindle assembly checkpoint in mouse oocyte meiosis. [PDF]
Cell Mol Life Sci, 2022 Zou YJ +7 more
europepmc +2 more sources
In-silico modeling of the mitotic spindle assembly checkpoint. [PDF]
PLoS ONE, 2008 The Mitotic Spindle Assembly Checkpoint ((M)SAC) is an evolutionary conserved mechanism that ensures the correct segregation of chromosomes by restraining cell cycle progression from entering anaphase until all chromosomes have made proper bipolar ...
Bashar Ibrahim +3 more
doaj +5 more sources
Nature Communications, 2019 Cell rounding at mitosis is driven by cortical tension and maintained through metaphase, although the mechanism is unknown. Here, the authors demonstrate that Cdk1 phosphorylation of DIAPH1 is required for both cortical tension maintenance and ...
Koutarou Nishimura +11 more
doaj +2 more sources
A Cell Biological Perspective on Past, Present and Future Investigations of the Spindle Assembly Checkpoint [PDF]
Biology, 2016 The spindle assembly checkpoint (SAC) is a quality control mechanism that ensures accurate chromosome segregation during cell division. It consists of a mechanochemical signal transduction mechanism that senses the attachment of chromosomes to the ...
Ajit P. Joglekar
semanticscholar +2 more sources
Cell Reports, 2018 Summary: Faithful chromosome segregation during mitosis depends on the spindle assembly checkpoint (SAC), which delays progression through mitosis until every chromosome has stably attached to spindle microtubules via the kinetochore.
Agnieszka Skowyra +3 more
doaj +2 more sources
Mitotic spindle disruption in human preimplantation embryos activates the spindle assembly checkpoint but not apoptosis until Day 5 of development [PDF]
Molecular human reproduction, 2017 STUDY QUESTION Is the spindle assembly checkpoint (SAC) active during human preimplantation development? SUMMARY ANSWER Mitotic spindle disruption during mitosis activates the SAC from at least Day 3 of human preimplantation development, but this does ...
Kurt Jacobs +5 more
semanticscholar +2 more sources