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The Spindle Assembly Checkpoint [PDF]
Current Biology, 2012 During mitosis and meiosis, the spindle assembly checkpoint acts to maintain genome stability by delaying cell division until accurate chromosome segregation can be guaranteed. Accuracy requires that chromosomes become correctly attached to the microtubule spindle apparatus via their kinetochores.
Lara-Gonzalez, Pablo +2 more
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Bub1 kinase in the regulation of mitosis
Animal Cells and Systems, 2021 Accurate chromosome segregation is required for cell survival and organismal development. During mitosis, the spindle assembly checkpoint acts as a safeguard to maintain the high fidelity of mitotic chromosome segregation by monitoring the attachment of ...
Taekyung Kim, Anton Gartner
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Yeast Kinesin-5 Motor Protein CIN8 Promotes Accurate Chromosome Segregation
Cells, 2022 Accurate chromosome segregation depends on bipolar chromosome–microtubule attachment and tension generation on chromosomes. Incorrect chromosome attachment results in chromosome missegregation, which contributes to genome instability.
Delaney Sherwin +2 more
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Spindle assembly checkpoint silencing and beyond [PDF]
Cell Cycle, 2016 The Spindle Assembly Checkpoint (SAC) prevents anaphase onset in the absence of kinetochore-microtubule attachment, ensuring that cells with unattached kinetochores do not proceed into anaphase.
Michael, Bokros, Yanchang, Wang
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Dynein Light Intermediate Chain 2 Facilitates the Metaphase to Anaphase Transition by Inactivating the Spindle Assembly Checkpoint. [PDF]
PLoS ONE, 2016 The multi-functional molecular motor cytoplasmic dynein performs diverse essential roles during mitosis. The mechanistic importance of the dynein Light Intermediate Chain homologs, LIC1 and LIC2 is unappreciated, especially in the context of mitosis ...
Sagar P Mahale +2 more
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Spindle assembly checkpoint, aneuploidy and tumorigenesis [PDF]
Cell Cycle, 2009 Faithfully distributing chromosomes into two daughter cells in mitosis is essential for the maintenance of the integrity of the genome genome. The fidelity is achieved through a number of cellular processes among which is the spindle assembly checkpoint (SAC), an elaborate molecular pathway that monitors the attachment of microtubules to kinetochores ...
Min, Li, Pumin, Zhang
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Haematologica, 2013 Spindle poison-based therapy is of only limited benefit in acute myeloid leukemia while lymphoblastic leukemia/lymphoma responds well. In this study, we demonstrated that the spindle assembly checkpoint protein BubR1 was down-regulated in the vast ...
Dominik Schnerch +7 more
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Cell Division, 2008 During mitosis, correct bipolar chromosome attachment to the mitotic spindle is an essential prerequisite for the equal segregation of chromosomes. The spindle assembly checkpoint can prevent chromosome segregation as long as not all chromosome pairs ...
Maia André F +2 more
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Kinetic framework of spindle assembly checkpoint signalling [PDF]
Nature Cell Biology, 2013 The mitotic spindle assembly checkpoint (SAC) delays anaphase onset until all chromosomes have attached to both spindle poles. Here, we investigated SAC signalling kinetics in response to acute detachment of individual chromosomes using laser microsurgery. Most detached chromosomes delayed anaphase until they had realigned to the metaphase plate.
Dick, Amalie E., Gerlich, Daniel W.
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The Spindle Assembly Checkpoint Is Required for Hematopoietic Progenitor Cell Engraftment
Stem Cell Reports, 2017 Summary: The spindle assembly checkpoint plays a pivotal role in preventing aneuploidy and transformation. Many studies demonstrate impairment of this checkpoint in cancer cells.
Andreas Brown +9 more
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