Results 21 to 30 of about 50,149 (285)
Tracing the Pathway of Spindle Assembly Checkpoint Signaling [PDF]
Developmental Cell, 2001 Most current models of spindle assembly checkpoint signaling involve inhibition of the Cdc20-APC by Mad2 protein. Interestingly, a paper from Hongtao Yu and colleagues in this issue of Developmental Cell suggests that the Cdc20/APC can also be inhibited in a Mad2-independent manner by a complex of proteins that includes BubR1.
Emily S. Gillett, Peter K. Sorger
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Multiple Duties for Spindle Assembly Checkpoint Kinases in Meiosis [PDF]
Frontiers in Cell and Developmental Biology, 2017 Cell division in mitosis and meiosis is governed by evolutionary highly conserved protein kinases and phosphatases, controlling the timely execution of key events such as nuclear envelope breakdown, spindle assembly, chromosome attachment to the spindle ...
A. Marston, Katja Wassmann
semanticscholar +6 more sources
Evolutionary Dynamics of the Spindle Assembly Checkpoint in Eukaryotes [PDF]
Current Biology, 2020 The tremendous diversity in eukaryotic life forms can ultimately be traced back to evolutionary modifications at the level of molecular networks. Deep understanding of these modifications will not only explain cellular diversity, but will also uncover different ways to execute similar processes and expose the evolutionary 'rules' that shape the ...
G. Kops, B. Snel, E. Tromer
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Loss of the Greatwall Kinase Weakens the Spindle Assembly Checkpoint
PLOS Genetics, 2016 The Greatwall kinase/Mastl is an essential gene that indirectly inhibits the phosphatase activity toward mitotic Cdk1 substrates. Here we show that although Mastl knockout (MastlNULL) MEFs enter mitosis, they progress through mitosis without completing ...
M. K. Diril +10 more
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The Molecular Biology of Spindle Assembly Checkpoint Signaling Dynamics [PDF]
Current Biology, 2015 The spindle assembly checkpoint is a safeguard mechanism that coordinates cell-cycle progression during mitosis with the state of chromosome attachment to the mitotic spindle. The checkpoint prevents mitotic cells from exiting mitosis in the presence of unattached or improperly attached chromosomes, thus avoiding whole-chromosome gains or losses and ...
A. Musacchio
semanticscholar +4 more sources
Aurora B phosphorylates Bub1 to promote spindle assembly checkpoint signaling
Current Biology, 2021 Accurate chromosome segregation during cell division requires amphitelic chromosome attachment to the spindle apparatus. It is ensured by the combined activity of the Spindle Assembly Checkpoint (SAC) [1], a signaling mechanism that delays anaphase onset
Babhrubahan Roy +4 more
semanticscholar +1 more source
The Spindle Assembly Checkpoint [PDF]
Current Biology, 2012 During mitosis and meiosis, the spindle assembly checkpoint acts to maintain genome stability by delaying cell division until accurate chromosome segregation can be guaranteed. Accuracy requires that chromosomes become correctly attached to the microtubule spindle apparatus via their kinetochores.
Lara-Gonzalez, Pablo +2 more
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The spindle assembly checkpoint [PDF]
Current Biology, 2008 (Current Biology 18, R391–R395; July 22, 2008)Because of an editorial mistake, Figure 1Figure 1 of this Primer shows pairs of kinetochores (indicated by pairs of yellow dots) during telophase, instead of single kinetochores as indicated in the corrected figure that appears here. The journal regrets this error.Figure 1The SAC as a synchronization device(
Varetti, Gianluca, Musacchio, Andrea
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Spindle assembly checkpoint silencing and beyond [PDF]
Cell Cycle, 2016 The Spindle Assembly Checkpoint (SAC) prevents anaphase onset in the absence of kinetochore-microtubule attachment, ensuring that cells with unattached kinetochores do not proceed into anaphase.
Michael Bokros, Yanchang Wang
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Bub1 kinase in the regulation of mitosis
Animal Cells and Systems, 2021 Accurate chromosome segregation is required for cell survival and organismal development. During mitosis, the spindle assembly checkpoint acts as a safeguard to maintain the high fidelity of mitotic chromosome segregation by monitoring the attachment of ...
Taekyung Kim, Anton Gartner
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