Results 81 to 90 of about 17,463 (177)
Human kinetochores are swivel joints that mediate microtubule attachments
eLife, 2016 Chromosome segregation is a mechanical process that requires assembly of the mitotic spindle – a dynamic microtubule-based force-generating machine.
Chris A Smith +2 more
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The RZZ Complex and the Spindle Assembly Checkpoint
Cell Structure and Function, 2009 The conserved protein Rod is found in various organisms. It is localized on the kinetochores or spindle microtubules during cell division. Rod is required for proper chromosome segregation during both mitosis and meiosis. The effects of rod mutations are similar for both equational and reductional divisions, giving rise to anaphases with lagging ...
Yujian, Lu +4 more
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Causes and consequences of maternal age-related aneuploidy in oocytes: a review
Veterinární Medicína, 2013 Although a positive correlation between aneuploidy and maternal age was first reported almost a century ago, the underlying mechanisms remain mostly unknown.
A. Danylevska, J. Sebestova
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The Spindle-Assembly Checkpoint, Aneuploidy, and Gastrointestinal Cancer [PDF]
New England Journal of Medicine, 2010 Genomic instability is a common occurrence in solid tumors, and it has long been conjectured that this process plays a causal role in cancer. The field of human molecular genetics has provided a means to test this hypothesis, fueled in part by the analysis of hereditary cancer-predisposition syndromes. Some of the first unequivocal support for the idea
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Proteome of oocyte spindle identifies Ccdc69 regulates spindle assembly like “band-tightening spell”
Cellular and Molecular Life SciencesMeiotic spindle is an intricate structure and required for chromosome segregation and the proper meiotic progression during oocyte maturation, and its function is regulated by a complex network of proteins located at spindle and its peripheral region ...
Jia-Ni Guo +12 more
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Spindle assembly checkpoint acquisition at the mid-blastula transition.
PLoS ONE, 2015 The spindle assembly checkpoint (SAC) maintains the fidelity of chromosome segregation during mitosis. Nonpathogenic cells lacking the SAC are typically only found in cleavage stage metazoan embryos, which do not acquire functional checkpoints until the ...
Maomao Zhang +2 more
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Advanced ScienceAs a major component of the cytoskeleton, intermediate filaments are generally considered to play a supporting role in mitotic cells. They also take part in the regulation of cell motility, proliferation, differentiation, and apoptosis.
Yu Li, Zihao Zhang, Yu Zhang, Bo Xiong
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A pivot-tether model for nucleosome recognition by the chromosomal passenger complex
EMBO ReportsSpatial restriction of Aurora B to T3-phosphorylated histone H3 (H3pT3) nucleosomes adjacent to centromeres during prometaphase and metaphase enables it to phosphorylate proteins necessary for spindle assembly checkpoint signalling and biorientation of ...
Reinis R Ruza +6 more
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Delayed Signaling in Mitotic Checkpoints: Biological Mechanisms and Modeling Perspectives
BiologyTime delays are intrinsic to mitotic regulation, particularly within the spindle assembly checkpoint (SAC) and the spindle position checkpoint (SPOC).
Bashar Ibrahim
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Signaling protein abundance modulates the strength of the spindle assembly checkpoint. [PDF]
Curr Biol, 2023 Jema S +5 more
europepmc +1 more source