Results 81 to 90 of about 50,149 (285)
Mechanical stability of bipolar spindle assembly [PDF]
, 2016 Assembly and stability of mitotic spindle is governed by the interplay of various intra-cellular forces, e.g. the forces generated by motor proteins by sliding overlapping anti-parallel microtubules (MTs) polymerized from the opposite centrosomes, the interaction of kinetochores with MTs, and the interaction of MTs with the chromosomes arms.
arxiv +1 more source
Defect driven shapes in nematic droplets: analogies with cell division [PDF]
Soft Matter 13, 1257 (2017), 2016 Building on the striking similarity between the structure of the spindle during mitosis in living cells and nematic textures in confined liquid crystals, we use a continuum model of two-dimensional nematic liquid crystal droplets, to examine the physical aspects of cell division.
arxiv +1 more source
Recent Progress on the Localization of the Spindle Assembly Checkpoint Machinery to Kinetochores
Cells, 2019 Faithful chromosome segregation during mitosis is crucial for maintaining genome stability. The spindle assembly checkpoint (SAC) is a surveillance mechanism that ensures accurate mitotic progression.
Zhen Dou +5 more
semanticscholar +1 more source
Advanced Science, EarlyView.Sperm‐derived circRNA‐1572 competitively binds to bta‐miR‐2478‐L‐2 through a “sponge” mechanism to regulate cyclin B2 (CCNB2) expression, thereby modulating the distribution of fibrous actin (F‐actin) in early pig embryos, ensuring proper chromosome segregation during mitosis, and facilitating normal embryo cleavage and zygotic genome activation.
Yanfang Wu +10 more
wiley +1 more source
Molecular basis of APC/C regulation by the spindle assembly checkpoint
Nature, 2016 In the dividing eukaryotic cell, the spindle assembly checkpoint (SAC) ensures that each daughter cell inherits an identical set of chromosomes. The SAC coordinates the correct attachment of sister chromatid kinetochores to the mitotic spindle with ...
C. Alfieri +6 more
semanticscholar +1 more source
Mitofusin 1 Drives Preimplantation Development by Enhancing Chromatin Incorporation of Histone H3.3
Advanced Science, EarlyView.MFN1 exerts its function partially through histone H3.3 in early embryos. MFN1 colocalizes with PADI6, and its deficiency results in compromised cytoplasmic lattices and ribosomal subunits, leading to declined H3.3 protein level. This, in turn, hinders the incorporation of H3.3 into the embryonic genome, thereby causing failure of male pronucleus ...
Xiao‐yan Shi +9 more
wiley +1 more source
In Vitro Studies of the Spindle Assembly Checkpoint in Yeast [PDF]
Biophysical Journal, 2014 Although extremely rare, errors in chromosome segregation lead to aneuploidy, which has been linked to cancer and birth defects. Dividing cells rely on a surveillance mechanism called the spindle assembly checkpoint (SAC), which ensures that chromosomes are properly segregated during mitosis.
Kwaku N. Opoku, Charles L. Asbury
openaire +2 more sources
The mitotic spindle in the one-cell C. elegans embryo is positioned with high precision and stability [PDF]
, 2016 Precise positioning of the mitotic spindle is important for specifying the plane of cell division, which in turn determines how the cytoplasmic contents are partitioned into the daughter cells, and how the daughters are positioned within the tissue. During metaphase in the early C.
arxiv +1 more source
Unveil Sleep Spindles with Concentration of Frequency and Time [PDF]
arXiv, 2023 Objective: Sleep spindles contain crucial brain dynamics information. We introduce the novel non-linear time-frequency analysis tool 'Concentration of Frequency and Time' (ConceFT) to create an interpretable automated algorithm for sleep spindle annotation in EEG data and to measure spindle instantaneous frequencies (IFs).
arxiv
Molecular Cancer Therapeutics, 2019 BOS172722 (CCT289346) is a highly potent, selective, and orally bioavailable inhibitor of spindle assembly checkpoint kinase MPS1. BOS172722 treatment alone induces significant sensitization to death, particularly in highly proliferative triple-negative ...
Simon J. Anderhub +20 more
semanticscholar +1 more source