Results 111 to 120 of about 4,752 (252)

ChemInform Abstract: Multicomponent Reaction Discovery: Three‐Component Synthesis of Spirooxindoles. [PDF]

ChemInform, 2010
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Corey R. J. Stephenson, Srinivas Kalidindi, Bo Liang, John A. Porco   +3 more
openaire   +4 more sources

Recent Advances in the Application of 2‐Aminobenzothiazole to the Multicomponent Synthesis of Heterocycles

ChemistryOpen, Volume 13, Issue 11, November 2024.
This review highlights recent advances in multicomponent reactions using 2‐aminobenzothiazole as a starting material in the synthesis of diverse heterocycles. These reactions enable the efficient and sustainable construction of novel bioactive molecules and pharmaceuticals.
Ramin Javahershenas, Jianlin Han, Mosstafa Kazemi, Peter J. Jervis   +3 more
wiley   +1 more source

Efficient synthesis of spirooxindole-pyrrolizidines and dispirooxindole-piperazines

Synthetic Communications, 2018
A simple and efficient approach for the construction of spirooxindole-pyrrolizidines and dispirooxindole-piperazines by cycloaddition reaction of azomethine ylide generated by isatin and proline has been demonstrated successfully. The formation of two different types of frameworks by two different modes of cycloaddition is explored.
Keshri Nath Tiwari, Taur Prakash Pandurang, Suyash Pant, P. Sreelekha   +3 more
openaire   +2 more sources

Synthesis of Fluorinated Spiroindolenines by Transition Metal‐Catalyzed Indole Dearomatizations

Advanced Synthesis &Catalysis, Volume 366, Issue 20, Page 4244-4252, October 25, 2024.
Abstract A strategy to access fluorinated spiroindolenines has been developed, involving a selective functionalization of indoles with fluorinated moieties and subsequent catalytic dearomatization. Trifluomethylthio (SCF3), diethyl phosphono(difluoromethyl)thio (SCF2P(O)(OEt)2) and (phenylsulfonyl)difluoromethyl (CF2SO2Ph) groups were embedded at the ...
Floris Buttard, Meriem Daghmoum, Mathieu Arribat, Mu‐Yi Chen, Pascal Retailleau, Tatiana Besset, Xavier Guinchard   +6 more
wiley   +1 more source

TP53 mutant MDM2-amplified cell lines selected for resistance to MDM2-p53 binding antagonists retain sensitivity to ionizing radiation [PDF]

, 2016
Non-genotoxic reactivation of the p53 pathway by MDM2-p53 binding antagonists is an attractive treatment strategy for wild-type TP53 cancers. To determine how resistance to MDM2/p53 binding antagonists might develop, SJSA-1 and NGP cells were exposed to ...
Bennaceur, Karim, DEL BELLO, FABIO, Drummond, Catherine J, Esfandiari, Arman, Griffin, Roger J, Hardcastle, Ian R, Hutton, Claire, Jackson, Jennifer, Liu, Junfeng, Lu, Xiaohong, Lunec, John, Makimanejavali, Aditya Rao, Newell, David R, PIERGENTILI, Alessandro, Xu, Qing   +14 more
core   +3 more sources

Catalytic Asymmetric Cycloadditions of Cyclic Sulfamidate Imines: Straightforward Access to Chiral N‐Heterocycles

Advanced Synthesis &Catalysis, Volume 366, Issue 19, Page 3926-3942, October 8, 2024.
Abstract Chiral N‐heterocyclic compounds are key structures in natural compounds and pharmaceuticals, and they serve as essential building blocks of functional materials. Catalytic asymmetric cycloaddition reactions represent one of the most efficient synthetic strategies for constructing optically active heterocycles.
Jong‐Un Park, Ju Hyun Kim
wiley   +1 more source

Catalytic Enantioselective Construction of Quaternary Stereocenters: Assembly of Key Building Blocks for the Synthesis of Biologically Active Molecules [PDF]

, 2015
The ever-present demand for drugs with better efficacy and fewer side effects continually motivates scientists to explore the vast chemical space. Traditionally, medicinal chemists have focused much attention on achiral or so-called “flat” molecules ...
Han, Seo-Jung, Liu, Wen-Bo, Liu, Yiyang, Stoltz, Brian M.   +3 more
core   +1 more source

A thermally-induced, tandem [3,3]-sigmatropic rearrangement/[2 + 2] cycloaddition approach to carbocyclic spirooxindoles

Beilstein Journal of Organic Chemistry, 2010
The synthesis of C3-carbocyclic spirooxindoles was realized by way of an intramolecular [2 + 2] cycloaddition reaction between a vinylidene indolin-2-one and an alkyne.
Kay M. Brummond, Joshua M. Osbourn
doaj   +1 more source

Visible Light‐Mediated Multicomponent Synthesis of Spirooxindole‐Linked Fused Pyrans: An Eco‐Friendly One‐Pot Strategy

ChemistrySelect, Volume 9, Issue 37, October 4, 2024.
We report a visible‐light‐mediated, catalyst‐free multicomponent reaction for the efficient synthesis of spirooxindole‐linked fused pyrans. The reaction involves isatin, malononitrile or its derivatives, and various cyclic 1,3‐dicarbonyl compounds such as 4‐hydroxy‐1‐methyl‐2(1H)‐quinolone, 4‐hydroxycoumarin, 4‐hydroxythiocoumarin, or barbituric acid ...
Nurabul Mondal, Darshika Singh, Vidya Kumari, Lokman H. Choudhury   +3 more
wiley   +1 more source

Isoniazid Hybrids As Potential Antitubercular Agents

ChemistrySelect, Volume 9, Issue 38, October 11, 2024.
Molecular hybridization is a rational drug design strategy that combines two or more covalently binding pharmacological agents into a single multifunctional molecule. The present review discusses the recent functionalizing of isoniazid to new hybrids tackling the menace of various forms of drug‐resistant tuberculosis and generating potential leads for ...
Sahil Mishra, Gobind Kumar, Parvesh Singh   +2 more
wiley   +1 more source