Results 111 to 120 of about 3,294 (234)
Synthesis of Fluorinated Spiroindolenines by Transition Metal‐Catalyzed Indole Dearomatizations
Advanced Synthesis &Catalysis, Volume 366, Issue 20, Page 4244-4252, October 25, 2024.Abstract A strategy to access fluorinated spiroindolenines has been developed, involving a selective functionalization of indoles with fluorinated moieties and subsequent catalytic dearomatization. Trifluomethylthio (SCF3), diethyl phosphono(difluoromethyl)thio (SCF2P(O)(OEt)2) and (phenylsulfonyl)difluoromethyl (CF2SO2Ph) groups were embedded at the ...
Floris Buttard +6 more
wiley +1 more source
Advanced Synthesis &Catalysis, Volume 366, Issue 19, Page 3926-3942, October 8, 2024.Abstract Chiral N‐heterocyclic compounds are key structures in natural compounds and pharmaceuticals, and they serve as essential building blocks of functional materials. Catalytic asymmetric cycloaddition reactions represent one of the most efficient synthetic strategies for constructing optically active heterocycles.
Jong‐Un Park, Ju Hyun Kim
wiley +1 more source
An evaluation of spirooxindoles as blocking agents of SARS-CoV-2 spike/ACE2 interaction : synthesis, biological evaluation and computational analysis [PDF]
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has gained significant public health attention owing to its devastating effects on lives and livelihoods worldwide.
Cassel, Joel +11 more
core +1 more source
Journal of Enzyme Inhibition and Medicinal Chemistry, 2020 In the current medical era, spirooxindole motif stands out as a privileged heterospirocyclic scaffold that represents the core for a wide range of bioactive naturally isolated products (such as Strychnofoline and spirotryprostatins A and B) and synthetic
Sara T. Al-Rashood +7 more
doaj +1 more source
Expanding the chemical diversity of spirooxindoles via alkylative pyridine dearomatization
Beilstein Journal of Organic Chemistry, 2012 A mild and practical synthesis of spirooxindole [1,3]oxazino derivatives from N-substituted isatins and 1,3-dicarbonyl compounds with pyridine derivatives is reported. The reactions provided good to excellent yields.
Chunhui Dai +2 more
doaj +1 more source
Spirooxadiazoline oxindoles: synthesis and evaluation of anticancer and antimalarial activities [PDF]
, 2017 Cancer is one of the modern world’s most common and deadly non-infectious disease. According to WHO Cancer Report of 2015, it is one of leading causes of morbidity and mortality worldwide with 8.8 million deaths in 2015 and it is expected to rise about ...
Lopes, Elizabeth de Abreu
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Morphological Profiling Identifies the Motor Protein Eg5 as Cellular Target of Spirooxindoles [PDF]
, 2023 Jie Liu +13 more
openalex +1 more source
The therapeutic potential of small molecules p53-MDM protein-protein interaction inhibitors [PDF]
, 2016 Tese de mestrado, Ciências Biofarmacêuticas, Universidade de Lisboa, Faculdade de Farmácia, 2016Ao longo dos anos, vários estudos científicos têm comprovado a importância da proteína supressora de tumor p53 na homeostase celular.
Nunes, Rute Cláudia Correia Sacadura
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