RSC Advances, 2015 The development of a versatile new one pot, catalyst free, multicomponent-tandem strategy for assembly of spirooxindole-indazolones and spirooxindole-pyrazolines is described.
Jagdamba Singh +4 more
openaire +3 more sources
PROteolysis‐Targeting Chimeras (PROTACs) in leukemia: overview and future perspectives
MedComm, Volume 5, Issue 6, June 2024.Antileukemic PROteolysis‐TArgeting Chimeras (PROTACs) induce degradation of leukemia‐associated targets, including resistance‐conferring mutant forms. PROTACs against leukemia have increased dramatically. Most antileukemic PROTACs, through an event‐driven mechanism, degrade the target potently, quickly, selectively, and with a long duration of action ...
André T. S. Vicente +1 more
wiley +1 more source
Green Synthesis and Catalysis, 2021 An uncommon aza-Diels-Alder reaction of electron-deficient azoalkenes and electron-deficient 3-phenacylideneoxindoles was successfully developed for convenient construction of the heterocyclic spirooxindoles.
Wenjing Shi, Jing Sun, Chao-Guo Yan
doaj
Asymmetric 1,3-Dipolar Cycloadditons of Stabilized Azomethine Ylides with Nitroalkenes [PDF]
, 2014 This review highlights the biological importance of many polysubstituted nitro-prolines and -pyrrolidines. Their preparation using asymmetric 1,3-dipolar cycloadditions of azomethine ylides with nitroalkenes using diastereoselective and enantioselective ...
Nájera, Carmen, Sansano, Jose M.
core +2 more sources
Antibacterial spirooxindole alkaloids from Penicillium brefeldianum inhibit dimorphism of pathogenic smut fungi [PDF]
, 2022 Huajun Shi +7 more
openalex +1 more source
A novel alpha‐amylase inhibitor‐based
, 2023 Mohammad Shahidul Islam +9 more
openalex +1 more source
The therapeutic potential of small molecules p53-MDM protein-protein interaction inhibitors [PDF]
, 2016 Tese de mestrado, Ciências Biofarmacêuticas, Universidade de Lisboa, Faculdade de Farmácia, 2016Ao longo dos anos, vários estudos científicos têm comprovado a importância da proteína supressora de tumor p53 na homeostase celular.
Nunes, Rute Cláudia Correia Sacadura
core
Expanding the chemical diversity of spirooxindoles via alkylative pyridine dearomatization
Beilstein Journal of Organic Chemistry, 2012 A mild and practical synthesis of spirooxindole [1,3]oxazino derivatives from N-substituted isatins and 1,3-dicarbonyl compounds with pyridine derivatives is reported. The reactions provided good to excellent yields.
Chunhui Dai +2 more
doaj +1 more source
Stereocontrolled Synthesis of Spirooxindoles through Lewis Acid-Promoted [5 + 2]-Annulation of Chiral Silyl Alcohols [PDF]
, 2009 Yun Zhang, James S. Panek
openalex +1 more source
Efficient Synthesis of Tetrahydrofuran Spirooxindoles via One-Pot Reaction [PDF]
, 2020 Xin Guo +5 more
openalex +1 more source