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The regulatory relationship between transcription factor STAT3 and noncoding RNA
Cellular & Molecular Biology LettersSignal transducer and activator of transcription 3 (STAT3), as a key node in numerous carcinogenic signaling pathways, is activated in various tumor tissues and plays important roles in tumor formation, metastasis, and drug resistance.
Siyi Liu +4 more
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CDK5RAP3 is a co-factor for the oncogenic transcription factor STAT3
Neoplasia: An International Journal for Oncology Research, 2020 The transcription factor STAT3 regulates genes governing critical cellular processes such as proliferation, survival, and self-renewal. While STAT3 transcriptional function is activated rapidly and transiently in response to physiologic signals, through ...
Susana P. Egusquiaguirre +10 more
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Decoy-PROTAC for specific degradation of “Undruggable” STAT3 transcription factor
Cell Death and DiseaseSignal transducer and activator of transcription 3 (STAT3) is widely recognized as an attractive target for cancer therapy due to its significant role in the initiation and progression of tumorigenesis.
Shiqing Li +10 more
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The crosstalk between STAT3 and microRNA in cardiac diseases and protection
Frontiers in Cardiovascular Medicine, 2022 Signal transducer and activator of transcription 3 (STAT3), an important transcription factor and signaling molecule, play an important role in cardiac disease and protection. As a transcription factor, STAT3 upregulates anti-oxidative and anti-apoptotic
Lan Wu +4 more
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A STAT3 protein complex required for mitochondrial mRNA stability and cancer
Cell Reports, 2023 Summary: Signal transducer and activator of transcription 3 (STAT3) is a potent transcription factor necessary for life whose activity is corrupted in diverse diseases, including cancer. STAT3 biology was presumed to be entirely dependent on its activity
C. Dilanka Fernando +8 more
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STAT3 and p63 in the Regulation of Cancer Stemness
Frontiers in Genetics, 2022 Signal transducer and activator of transcription 3 (STAT3) is a transcription factor with many important functions in normal and transformed cells. STAT3 regulatory activities are highly complex as they are involved in various signaling pathways in ...
Shixiong Wei +6 more
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Biomedicines, 2021 Autophagy in the proximal tubules may promote fibrosis by activating tubular cell death, interstitial inflammation, and the production of pro-fibrotic factors.
Young-Ah Kim +8 more
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Targeting the transcriptional activity of STAT3 by a novel fusion protein
BMC Cancer, 2022 Background The continuous activation of transcription factors drives many diseases, including tumors, autoimmune disease, neurodegenerative disease, and male infertility.
Yanqiong Chen +3 more
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Mechanisms of Unphosphorylated STAT3 Transcription Factor Binding to DNA [PDF]
Journal of Biological Chemistry, 2012 Phosphorylation of signal transducer and activator of transcription 3 (STAT3) on a single tyrosine residue in response to growth factors, cytokines, interferons, and oncogenes activates its dimerization, translocation to the nucleus, binding to the interferon γ (gamma)-activated sequence (GAS) DNA-binding site and activation of transcription of target ...
Timofeeva, Olga A. +12 more
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The Roles of Post-Translational Modifications in STAT3 Biological Activities and Functions
Biomedicines, 2021 STAT3 is an important transcription factor that regulates cell growth and proliferation by regulating gene transcription of a plethora of genes. This protein also has many roles in cancer progression and several tumors such as prostate, lung, breast, and
Annachiara Tesoriere +2 more
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