Biochemical Properties of a Decoy Oligodeoxynucleotide Inhibitor of STAT3 Transcription Factor. [PDF]
Int J Mol Sci, 2018 Cyclic STAT3 decoy (CS3D) is a second-generation, double-stranded oligodeoxynucleotide (ODN) that mimics a genomic response element for signal transducer and activator of transcription 3 (STAT3), an oncogenic transcription factor.
Lee DS +5 more
europepmc +6 more sources
Inhibitory Effects of STAT3 Transcription Factor by Synthetic Decoy ODNs on Autophagy in Renal Fibrosis [PDF]
Biomedicines, 2021 Autophagy in the proximal tubules may promote fibrosis by activating tubular cell death, interstitial inflammation, and the production of pro-fibrotic factors.
Young-Ah Kim +8 more
doaj +2 more sources
Decoy-PROTAC for specific degradation of “Undruggable” STAT3 transcription factor [PDF]
Cell Death and DiseaseSignal transducer and activator of transcription 3 (STAT3) is widely recognized as an attractive target for cancer therapy due to its significant role in the initiation and progression of tumorigenesis.
Shiqing Li +10 more
doaj +2 more sources
Evaluation of the putative lymphoma-associated point mutation D427H in the STAT3 transcription factor. [PDF]
BMC Mol Cell Biol, 2022 Behrendsen LS +6 more
europepmc +3 more sources
The crosstalk between STAT3 and microRNA in cardiac diseases and protection
Frontiers in Cardiovascular Medicine, 2022 Signal transducer and activator of transcription 3 (STAT3), an important transcription factor and signaling molecule, play an important role in cardiac disease and protection. As a transcription factor, STAT3 upregulates anti-oxidative and anti-apoptotic
Lan Wu +4 more
doaj +1 more source
A STAT3 protein complex required for mitochondrial mRNA stability and cancer
Cell Reports, 2023 Summary: Signal transducer and activator of transcription 3 (STAT3) is a potent transcription factor necessary for life whose activity is corrupted in diverse diseases, including cancer. STAT3 biology was presumed to be entirely dependent on its activity
C. Dilanka Fernando +8 more
doaj +1 more source
STAT3 and p63 in the Regulation of Cancer Stemness
Frontiers in Genetics, 2022 Signal transducer and activator of transcription 3 (STAT3) is a transcription factor with many important functions in normal and transformed cells. STAT3 regulatory activities are highly complex as they are involved in various signaling pathways in ...
Shixiong Wei +6 more
doaj +1 more source
Correction: Decoy-PROTAC for specific degradation of “Undruggable” STAT3 transcription factor [PDF]
Cell Death and DiseaseShiqing Li +10 more
doaj +2 more sources
Targeting the transcriptional activity of STAT3 by a novel fusion protein
BMC Cancer, 2022 Background The continuous activation of transcription factors drives many diseases, including tumors, autoimmune disease, neurodegenerative disease, and male infertility.
Yanqiong Chen +3 more
doaj +1 more source
The Roles of Post-Translational Modifications in STAT3 Biological Activities and Functions
Biomedicines, 2021 STAT3 is an important transcription factor that regulates cell growth and proliferation by regulating gene transcription of a plethora of genes. This protein also has many roles in cancer progression and several tumors such as prostate, lung, breast, and
Annachiara Tesoriere +2 more
doaj +1 more source