Results 11 to 20 of about 196,678 (325)

The regulatory relationship between transcription factor STAT3 and noncoding RNA

Cellular & Molecular Biology Letters
Signal transducer and activator of transcription 3 (STAT3), as a key node in numerous carcinogenic signaling pathways, is activated in various tumor tissues and plays important roles in tumor formation, metastasis, and drug resistance.
Siyi Liu, Wentao Li, Lin Liang, Yanhong Zhou, Yanling Li   +4 more
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CDK5RAP3 is a co-factor for the oncogenic transcription factor STAT3

Neoplasia: An International Journal for Oncology Research, 2020
The transcription factor STAT3 regulates genes governing critical cellular processes such as proliferation, survival, and self-renewal. While STAT3 transcriptional function is activated rapidly and transiently in response to physiologic signals, through ...
Susana P. Egusquiaguirre, Suhu Liu, Isidora Tošić, Kevin Jiang, Sarah R. Walker, Maria Nicolais, Tzuen Yih Saw, Michael Xiang, Katarina Bartel, Erik A. Nelson, David A. Frank   +10 more
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Activation of Stat3 Transcription Factor by Herpesvirus Saimiri STP-A Oncoprotein [PDF]

Journal of Virology, 2004
ABSTRACT The saimiri transforming protein (STP) oncogene of Herpesvirus saimiri subgroup A strain 11 (STP-A11) is not required for viral replication but is required for lymphoid cell immortalization in culture and lymphoma induction in primates. We previously showed that STP-A11 interacts with cellular Src
Young-Hwa Chung, Nam‐Hyuk Cho, María I. Rodríguez García, Sun Hwa Lee, Pinghui Feng, Jae U. Jung   +5 more
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Role of Unphosphorylated Transcription Factor STAT3 in Late Cerebral Ischemia after Subarachnoid Hemorrhage [PDF]

Journal of Cerebral Blood Flow & Metabolism, 2014
Molecular mechanisms behind increased cerebral vasospasm and local inflammation in late cerebral ischemia after subarachnoid hemorrhage (SAH) are poorly elucidated. Using system biology tools and experimental SAH models, we have identified signal transducer and activator of transcription 3 (STAT3) transcription factor as a possible major regulatory ...
Ajoy Kumar Samraj, Anne Müller, Anne-Sofie Grell, Lars Edvinsson   +3 more
openalex   +4 more sources

STAT3β, a Splice Variant of Transcription Factor STAT3, Is a Dominant Negative Regulator of Transcription [PDF]

Journal of Biological Chemistry, 1996
The 89-kDa STAT3 protein is a latent transcription factor which is activated in response to cytokines (interleukin (IL)-5 and -6) and growth factors (epidermal growth factor). Binding of IL-5 to its specific receptor activates JAK2 which leads to the tyrosine phosphorylation of STAT3 proteins.
Eric Caldenhoven, Thamar B. van Dijk, Roberto Solari, J. T. Armstrong, Jan A. M. Raaijmakers, Jan‐Willem J. Lammers, Leo Koenderman, Rolf P. de Groot   +7 more
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Transcription Factor STAT3 as a Novel Molecular Target for Cancer Prevention [PDF]

Cancers, 2014
Signal Transducers and Activators of Transcription (STATs) are a family of transcription factors that regulate cell proliferation, differentiation, apoptosis, immune and inflammatory responses, and angiogenesis. Cumulative evidence has established that STAT3 has a critical role in the development of multiple cancer types.
Ailian Xiong, Zhengduo Yang, Yi‐Cheng Shen, Jia Zhou, Qiang Shen   +4 more
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Mechanisms of Unphosphorylated STAT3 Transcription Factor Binding to DNA [PDF]

Journal of Biological Chemistry, 2012
Phosphorylation of signal transducer and activator of transcription 3 (STAT3) on a single tyrosine residue in response to growth factors, cytokines, interferons, and oncogenes activates its dimerization, translocation to the nucleus, binding to the interferon γ (gamma)-activated sequence (GAS) DNA-binding site and activation of transcription of target ...
Timofeeva, Olga A., Chasovskikh, Sergey, Lonskaya, Irina, Tarasova, Nadya I., Khavrutskii, Lyuba, Tarasov, Sergey G., Zhang, Xueping, Korostyshevskiy, Valeriy R., Cheema, Amrita, Zhang, Lihua, Dakshanamurthy, Sivanesan, Brown, Milton L., Dritschilo, Anatoly   +12 more
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Rapid activation of the STAT3 transcription factor by granulocyte colony-stimulating factor [PDF]

Blood, 1994
Abstract Granulocyte colony-stimulating factor (G-CSF) is a glycoprotein that stimulates proliferation and differentiation of progenitor cells of neutrophils by signaling through its receptor (G-CSFR). Although the G- CSFR belongs to the cytokine receptor superfamily, which lacks an intracellular kinase domain, G-CSF-induced tyrosine ...
S S, Tian, P, Lamb, H M, Seidel, R B, Stein, J, Rosen   +4 more
openaire   +3 more sources

Deletion of STAT3 from Foxd1 cell population protects mice from kidney fibrosis by inhibiting pericytes trans-differentiation and migration

Cell Reports, 2022
Summary: Signal transduction and activator of transcription 3 (STAT3) is a key transcription factor implicated in the pathogenesis of kidney fibrosis.
Amrendra K. Ajay, Li Zhao, Shruti Vig, Mai Fujiwara, Sudhir Thakurela, Shreyas Jadhav, Andrew Cho, I-Jen Chiu, Yan Ding, Krithika Ramachandran, Arushi Mithal, Aanal Bhatt, Pratyusha Chaluvadi, Manoj K. Gupta, Sujal I. Shah, Venkata S. Sabbisetti, Ana Maria Waaga-Gasser, David A. Frank, Gopal Murugaiyan, Joseph V. Bonventre, Li-Li Hsiao   +20 more
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Germline STAT3 gain-of-function mutations in primary immunodeficiency: Impact on the cellular and clinical phenotype

Biomedical Journal, 2021
Signal transducer and activator of transcription 3 (STAT3) is a key transcription factor involved in regulation of immune cell activation and differentiation.
Laura Faletti, Stephan Ehl, Maximilian Heeg   +2 more
doaj   +1 more source