Results 11 to 20 of about 136,793 (261)

Biochemical Properties of a Decoy Oligodeoxynucleotide Inhibitor of STAT3 Transcription Factor [PDF]

International Journal of Molecular Sciences, 2018
Cyclic STAT3 decoy (CS3D) is a second-generation, double-stranded oligodeoxynucleotide (ODN) that mimics a genomic response element for signal transducer and activator of transcription 3 (STAT3), an oncogenic transcription factor. CS3D competitively inhibits STAT3 binding to target gene promoters, resulting in decreased expression of proteins that ...
David S. Lee, Rachel A. O'Keefe, Patrick K. Ha, Jennifer R. Grandis, Daniel E. Johnson   +4 more
openaire   +5 more sources

Correction: Decoy-PROTAC for specific degradation of “Undruggable” STAT3 transcription factor [PDF]

Cell Death and Disease
Shiqing Li, Xin Wang, Jiabao Huang, Xiuping Cao, Yana Liu, Shiyan Bai, Tao Zeng, Qi Chen, Chunsen Li, Chunhua Lu, Huanghao Yang   +10 more
doaj   +3 more sources

Rapid activation of the STAT3 transcription factor by granulocyte colony-stimulating factor [PDF]

Blood, 1994
Abstract Granulocyte colony-stimulating factor (G-CSF) is a glycoprotein that stimulates proliferation and differentiation of progenitor cells of neutrophils by signaling through its receptor (G-CSFR). Although the G- CSFR belongs to the cytokine receptor superfamily, which lacks an intracellular kinase domain, G-CSF-induced tyrosine ...
S S, Tian, P, Lamb, H M, Seidel, R B, Stein, J, Rosen   +4 more
openaire   +3 more sources

Deletion of STAT3 from Foxd1 cell population protects mice from kidney fibrosis by inhibiting pericytes trans-differentiation and migration

Cell Reports, 2022
Summary: Signal transduction and activator of transcription 3 (STAT3) is a key transcription factor implicated in the pathogenesis of kidney fibrosis.
Amrendra K. Ajay, Li Zhao, Shruti Vig, Mai Fujiwara, Sudhir Thakurela, Shreyas Jadhav, Andrew Cho, I-Jen Chiu, Yan Ding, Krithika Ramachandran, Arushi Mithal, Aanal Bhatt, Pratyusha Chaluvadi, Manoj K. Gupta, Sujal I. Shah, Venkata S. Sabbisetti, Ana Maria Waaga-Gasser, David A. Frank, Gopal Murugaiyan, Joseph V. Bonventre, Li-Li Hsiao   +20 more
doaj   +1 more source

Germline STAT3 gain-of-function mutations in primary immunodeficiency: Impact on the cellular and clinical phenotype

Biomedical Journal, 2021
Signal transducer and activator of transcription 3 (STAT3) is a key transcription factor involved in regulation of immune cell activation and differentiation.
Laura Faletti, Stephan Ehl, Maximilian Heeg   +2 more
doaj   +1 more source

Gas6 Induces Mesangial Cell Proliferation via Latent Transcription Factor STAT3 [PDF]

Journal of Biological Chemistry, 2001
Mesangial cell proliferation is essential for the pathogenesis and progression of glomerular disease. Previously, we showed that Gas6 plays a pivotal role in mesangial cell proliferation in vitro and in vivo. In the present study, we identified downstream targets of Gas6 signaling to examine the role in mesangial cell proliferation in vitro and in vivo.
M, Yanagita, H, Arai, T, Nakano, K, Ohashi, K, Mizuno, A, Fukatsu, T, Doi, T, Kita   +7 more
openaire   +2 more sources

An Update on the Multifaceted Roles of STAT3 in the Heart

Frontiers in Cardiovascular Medicine, 2019
Signal transducer and activator of transcription 3 (STAT3) is a signaling molecule and transcription factor that plays important protective roles in the heart.
Zeina Harhous, Zeina Harhous, Zeina Harhous, George W. Booz, Michel Ovize, Michel Ovize, Gabriel Bidaux, Gabriel Bidaux, Mazen Kurdi   +8 more
doaj   +1 more source

Biological Hallmarks and Emerging Strategies to Target STAT3 Signaling in Multiple Myeloma

Cells, 2022
Multiple myeloma (MM) is the second most common hematological malignancy, characterized by an abnormal accumulation of plasma cells in the bone marrow. Signal transducer and activator of transcription 3 (STAT3) is a cytoplasmic transcription factor that ...
Jianbiao Zhou, Wee-Joo Chng
doaj   +1 more source

Activation of the STAT3/Acute Phase Response Factor Transcription Factor by Interleukin-5 [PDF]

Journal of Biological Chemistry, 1995
The receptor for interleukin-5 (IL-5R) is composed of a unique alpha chain (IL-5R alpha) expressed on eosinophils and basophils, associated with a beta c subunit, which is shared by the receptors for IL-3 and granulocyte macrophage-colony stimulating factor. One of the molecular events activated via the IL-5R is the JAK/STAT signaling pathway.
Caldenhoven, Eric, Dijk, Thamar B. van, Raaijmakers, J.A.M., Lammers, J.W.J., Koenderman, L., Groot, Rolf P. de   +5 more
openaire   +3 more sources

Direct Upregulation of STAT3 by MicroRNA-551b-3p Deregulates Growth and Metastasis of Ovarian Cancer

Cell Reports, 2016
Summary: 3q26.2 amplification in high-grade serous ovarian cancer leads to increased expression of mature microRNA miR551b-3p, which is associated with poor clinical outcome.
Pradeep Chaluvally-Raghavan, Kang Jin Jeong, Sunila Pradeep, Andreia Machado Silva, Shuangxing Yu, Wenbin Liu, Tyler Moss, Cristian Rodriguez-Aguayo, Dong Zhang, Prahlad Ram, Jinsong Liu, Yiling Lu, Gabriel Lopez-Berestein, George A. Calin, Anil K. Sood, Gordon B. Mills   +15 more
doaj   +1 more source