Activation of Acute Phase Response Factor (APRF)/Stat3 Transcription Factor by Growth Hormone [PDF]
Journal of Biological Chemistry, 1995 The mechanism by which the binding of growth hormone (GH) to its cell surface receptor elicits changes in gene transcription are largely unknown. The transcription factor Stat1/p91 has been shown to be activated by GH. Here we show that acute phase response factor or Stat3 f1p4an antigenically related protein), is also activated by GH.
G S, Campbell +5 more
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Frontiers in Immunology, 2020 Signal transducer and activator of transcription 3 (STAT3) is implicated in inflammation processing, but the mechanism of its regulation mostly remains limited to Janus kinase (JAK)-mediated phosphorylation.
Hui Gong +18 more
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Transcription Factor STAT3 as a Novel Molecular Target for Cancer Prevention [PDF]
Cancers, 2014 Signal Transducers and Activators of Transcription (STATs) are a family of transcription factors that regulate cell proliferation, differentiation, apoptosis, immune and inflammatory responses, and angiogenesis. Cumulative evidence has established that STAT3 has a critical role in the development of multiple cancer types.
Ailian Xiong +4 more
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Identification of novel regulators of STAT3 activity.
PLoS ONE, 2020 STAT3 mediates signalling downstream of cytokine and growth factor receptors where it acts as a transcription factor for its target genes, including oncogenes and cell survival regulating genes.
Elina Parri +4 more
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Suppression of STAT3 and HIF-1 alpha mediates anti-angiogenic activity of betulinic acid in hypoxic PC-3 prostate cancer cells. [PDF]
PLoS ONE, 2011 BACKGROUND: Signal transducer and activator of transcription 3 (STAT3) is a transcription factor that regulates various cellular processes such as cell survival, angiogenesis and proliferation.
Jimin Shin +12 more
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Functional Interaction of STAT3 Transcription Factor with the Coactivator NcoA/SRC1a [PDF]
Journal of Biological Chemistry, 2002 Signal transducer and activator of transcription 3 (STAT3) transcription factors are cytoplasmic proteins that induce gene activation in response to cytokine receptor stimulation. Following tyrosine phosphorylation, STAT3 proteins dimerize, translocate to the nucleus, and activate specific target genes. This transcriptional activation by STAT3 proteins
Sandrine, Giraud +5 more
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A model for how signal duration can determine distinct outcomes of gene transcription programs. [PDF]
PLoS ONE, 2012 The reason why IL-6 induces a pro-inflammatory response, while IL-10 induces an anti-inflammatory response, despite both cytokines activating the same transcription factor, STAT3, is not well understood.
Kevin D Fowler +2 more
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STAT3 plays an important role in DNA replication by turning on WDHD1
Cell & Bioscience, 2021 Background Signal transducers and activators of transcription 3 (STAT3) is a transcription factor that plays a key role in many cellular processes such as cell growth and cancer.
Yunying Zhou, Jason J. Chen
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Signal Transducer and Activator of Transcription 3 Control of Human T and B Cell Responses
Frontiers in Immunology, 2018 Signal transducer and activator of transcription 3 (STAT3) is a transcription factor that is activated downstream of many key cytokine receptors expressed by lymphocytes.
Elissa K. Deenick +9 more
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Prediction and experimental validation of novel STAT3 target genes in human cancer cells. [PDF]
PLoS ONE, 2009 The comprehensive identification of functional transcription factor binding sites (TFBSs) is an important step in understanding complex transcriptional regulatory networks.
Young Min Oh +4 more
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