Results 21 to 30 of about 196,678 (325)

Gas6 Induces Mesangial Cell Proliferation via Latent Transcription Factor STAT3 [PDF]

Journal of Biological Chemistry, 2001
Mesangial cell proliferation is essential for the pathogenesis and progression of glomerular disease. Previously, we showed that Gas6 plays a pivotal role in mesangial cell proliferation in vitro and in vivo. In the present study, we identified downstream targets of Gas6 signaling to examine the role in mesangial cell proliferation in vitro and in vivo.
M, Yanagita, H, Arai, T, Nakano, K, Ohashi, K, Mizuno, A, Fukatsu, T, Doi, T, Kita   +7 more
openaire   +2 more sources

TYK2-induced phosphorylation of Y640 suppresses STAT3 transcriptional activity [PDF]

, 2017
STAT3 is a pleiotropic transcription factor involved in homeostatic and host defense processes in the human body. It is activated by numerous cytokines and growth factors and generates a series of cellular effects.
De Bosscher, Karolien, De Cauwer, Lode, Icardi, Laura, Mori, Raffaele, Peelman, Frank, Tavernier, Jan, Van Der Heyden, José, Wauman, Joris   +7 more
core   +3 more sources

Sequestration of the Transcription Factor STAT3 by the Molecular Chaperone CCT: A Potential Mechanism for Modulation of STAT3 Phosphorylation

Journal of Molecular Biology, 2021
Chaperonin Containing Tailless complex polypeptide 1 (CCT) is an essential molecular chaperone required for the folding of the abundant proteins actin and tubulin. The CCT oligomer also folds a range of other proteins and participates in non-folding activities such as providing assembly support for complexes of the von Hippel Lindau tumor suppressor ...
Josefine Vallin, Carmen M. Córdoba-Beldad, Julie Grantham   +2 more
openalex   +3 more sources

An Update on the Multifaceted Roles of STAT3 in the Heart

Frontiers in Cardiovascular Medicine, 2019
Signal transducer and activator of transcription 3 (STAT3) is a signaling molecule and transcription factor that plays important protective roles in the heart.
Zeina Harhous, Zeina Harhous, Zeina Harhous, George W. Booz, Michel Ovize, Michel Ovize, Gabriel Bidaux, Gabriel Bidaux, Mazen Kurdi   +8 more
doaj   +1 more source

Biological Hallmarks and Emerging Strategies to Target STAT3 Signaling in Multiple Myeloma

Cells, 2022
Multiple myeloma (MM) is the second most common hematological malignancy, characterized by an abnormal accumulation of plasma cells in the bone marrow. Signal transducer and activator of transcription 3 (STAT3) is a cytoplasmic transcription factor that ...
Jianbiao Zhou, Wee-Joo Chng
doaj   +1 more source

Activation of the STAT3/Acute Phase Response Factor Transcription Factor by Interleukin-5 [PDF]

Journal of Biological Chemistry, 1995
The receptor for interleukin-5 (IL-5R) is composed of a unique alpha chain (IL-5R alpha) expressed on eosinophils and basophils, associated with a beta c subunit, which is shared by the receptors for IL-3 and granulocyte macrophage-colony stimulating factor. One of the molecular events activated via the IL-5R is the JAK/STAT signaling pathway.
Caldenhoven, Eric, Dijk, Thamar B. van, Raaijmakers, J.A.M., Lammers, J.W.J., Koenderman, L., Groot, Rolf P. de   +5 more
openaire   +3 more sources

Direct Upregulation of STAT3 by MicroRNA-551b-3p Deregulates Growth and Metastasis of Ovarian Cancer

Cell Reports, 2016
Summary: 3q26.2 amplification in high-grade serous ovarian cancer leads to increased expression of mature microRNA miR551b-3p, which is associated with poor clinical outcome.
Pradeep Chaluvally-Raghavan, Kang Jin Jeong, Sunila Pradeep, Andreia Machado Silva, Shuangxing Yu, Wenbin Liu, Tyler Moss, Cristian Rodriguez-Aguayo, Dong Zhang, Prahlad Ram, Jinsong Liu, Yiling Lu, Gabriel Lopez-Berestein, George A. Calin, Anil K. Sood, Gordon B. Mills   +15 more
doaj   +1 more source

Targeting STAT3 in Cancer with Nucleotide Therapeutics. [PDF]

, 2019
Signal transducer and activator of transcription 3 (STAT3) plays a critical role in promoting the proliferation and survival of tumor cells. As a ubiquitously-expressed transcription factor, STAT3 has commonly been considered an "undruggable" target for ...
Grandis, Jennifer R, Johnson, Daniel E, Lau, Yue-Ting K, Ramaiyer, Malini   +3 more
core   +2 more sources

Activation of Acute Phase Response Factor (APRF)/Stat3 Transcription Factor by Growth Hormone [PDF]

Journal of Biological Chemistry, 1995
The mechanism by which the binding of growth hormone (GH) to its cell surface receptor elicits changes in gene transcription are largely unknown. The transcription factor Stat1/p91 has been shown to be activated by GH. Here we show that acute phase response factor or Stat3 f1p4an antigenically related protein), is also activated by GH.
G S, Campbell, D J, Meyer, R, Raz, D E, Levy, J, Schwartz, C, Carter-Su   +5 more
openaire   +2 more sources

Dynamic telomerase gene suppression via network effects of GSK3 inhibition [PDF]

, 2009
<b>Background</b>: Telomerase controls telomere homeostasis and cell immortality and is a promising anti-cancer target, but few small molecule telomerase inhibitors have been developed. Reactivated transcription of the catalytic subunit hTERT
Bilsland, Alan E., Burns, Sharon, Cairney, Claire, Gomez-Roman, Natividad, Hammonds, Tim, Hoare, Stacey, Keith, W. Nicol, Lafferty-Whyte, Kyle, Plumb, Jane, Roffey, Jon, Stevenson, Katrina   +10 more
core   +9 more sources