Frontiers in Immunology, 2020 Signal transducer and activator of transcription 3 (STAT3) is implicated in inflammation processing, but the mechanism of its regulation mostly remains limited to Janus kinase (JAK)-mediated phosphorylation.
Hui Gong +18 more
doaj +1 more source
Identification of the missing pluripotency mediator downstream of leukaemia inhibitory factor [PDF]
, 2013 Self-renewal of pluripotent mouse embryonic stem (ES) cells is sustained by the cytokine leukaemia inhibitory factor (LIF) acting through the transcription factor Stat3.
Bertone, P, Martello, G, Smith, A
core +1 more source
Genetic partitioning of interleukin-6 signalling in mice dissociates Stat3 from Smad3-mediated lung fibrosis [PDF]
, 2012 Idiopathic pulmonary fibrosis (IPF) is a fatal disease that is unresponsive to current therapies and characterized by excessive collagen deposition and subsequent fibrosis.
Anderson, G.P. +19 more
core +2 more sources
Identification of novel regulators of STAT3 activity.
PLoS ONE, 2020 STAT3 mediates signalling downstream of cytokine and growth factor receptors where it acts as a transcription factor for its target genes, including oncogenes and cell survival regulating genes.
Elina Parri +4 more
doaj +1 more source
Suppression of STAT3 and HIF-1 alpha mediates anti-angiogenic activity of betulinic acid in hypoxic PC-3 prostate cancer cells. [PDF]
PLoS ONE, 2011 BACKGROUND: Signal transducer and activator of transcription 3 (STAT3) is a transcription factor that regulates various cellular processes such as cell survival, angiogenesis and proliferation.
Jimin Shin +12 more
doaj +1 more source
Progestins induce transcriptional activation of signal transducer and activator of transcription 3 (Stat3) via a Jak- and Src-dependent mechanism in breast cancer cells [PDF]
, 2005 Interactions between steroid hormone receptors and signal transducer and activator of transcription (Stat)-mediated signaling pathways have already been described.
Carnevale, Romina Paula +10 more
core +3 more sources
Functional Interaction of STAT3 Transcription Factor with the Coactivator NcoA/SRC1a [PDF]
Journal of Biological Chemistry, 2002 Signal transducer and activator of transcription 3 (STAT3) transcription factors are cytoplasmic proteins that induce gene activation in response to cytokine receptor stimulation. Following tyrosine phosphorylation, STAT3 proteins dimerize, translocate to the nucleus, and activate specific target genes. This transcriptional activation by STAT3 proteins
Sandrine, Giraud +5 more
openaire +2 more sources
A model for how signal duration can determine distinct outcomes of gene transcription programs. [PDF]
PLoS ONE, 2012 The reason why IL-6 induces a pro-inflammatory response, while IL-10 induces an anti-inflammatory response, despite both cytokines activating the same transcription factor, STAT3, is not well understood.
Kevin D Fowler +2 more
doaj +1 more source
STAT3 plays an important role in DNA replication by turning on WDHD1
Cell & Bioscience, 2021 Background Signal transducers and activators of transcription 3 (STAT3) is a transcription factor that plays a key role in many cellular processes such as cell growth and cancer.
Yunying Zhou, Jason J. Chen
doaj +1 more source
The Stat3-Fam3a axis promotes muscle stem cell myogenic lineage progression by inducing mitochondrial respiration. [PDF]
, 2019 Metabolic reprogramming is an active regulator of stem cell fate choices, and successful stem cell differentiation in different compartments requires the induction of oxidative phosphorylation.
Cunningham, Thomas J +9 more
core +3 more sources