Results 31 to 40 of about 136,793 (261)

STAT3β, a Splice Variant of Transcription Factor STAT3, Is a Dominant Negative Regulator of Transcription [PDF]

Journal of Biological Chemistry, 1996
The 89-kDa STAT3 protein is a latent transcription factor which is activated in response to cytokines (interleukin (IL)-5 and -6) and growth factors (epidermal growth factor). Binding of IL-5 to its specific receptor activates JAK2 which leads to the tyrosine phosphorylation of STAT3 proteins.
Caldenhoven, Eric, Dijk, Thamar B. van, Solari, Roberto, Armstrong, John, Raaijmakers, J.A.M., Lammers, J.W.J., Koenderman, L., Groot, Rolf P. de   +7 more
openaire   +4 more sources

Sorafenib Sensitizes Glioma Cells to the BH3 Mimetic ABT-737 by Targeting MCL1 in a STAT3-Dependent Manner

Neoplasia: An International Journal for Oncology Research, 2015
The oncogenic transcription factor signal transducer and activator of transcription 3 (STAT3) is overactivated in malignant glioma and plays a key role in promoting cell survival, thereby increasing the acquired apoptosis resistance of these tumors. Here
Irina Kiprianova, Janina Remy, Nelli Milosch, Isabelle V. Mohrenz, Volker Seifert, Achim Aigner, Donat Kögel   +6 more
doaj   +1 more source

Foxm1 mediates LIF/Stat3-dependent self-renewal in mouse embryonic stem cells and is essential for the generation of induced pluripotent stem cells. [PDF]

PLoS ONE, 2014
Activation of signal transducer and activator of transcription 3 (Stat3) by leukemia inhibitory factor (LIF) is required for maintaining self-renewal and pluripotency of mouse embryonic stem cells (mESCs).
Guixiang Tan, Liang Cheng, Tuanhui Chen, Li Yu, Yongjun Tan   +4 more
doaj   +1 more source

Targeting STAT3 Signaling Pathway in Colorectal Cancer

Biomedicines, 2021
Signal transducer and activator of transcription 3 (STAT3) is a critical transcription factor that has been firmly associated with colorectal cancer (CRC) initiation and development. STAT3 mediates key inflammatory mechanisms in colitis-associated cancer,
Antonios N. Gargalionis, Kostas A. Papavassiliou, Athanasios G. Papavassiliou   +2 more
doaj   +1 more source

STAT3 is Activated by CTGF-mediated Tumor-stroma Cross Talk to Promote HCC ProgressionSummary

Cellular and Molecular Gastroenterology and Hepatology, 2023
Background & Aims: Signal transducer and activator of transcription 3 (STAT3) is known as a pro-oncogenic transcription factor. Regarding liver carcinogenesis, however, it remains controversial whether activated STAT3 is pro- or anti-tumorigenic ...
Yuki Makino, Hayato Hikita, Seiya Kato, Masaya Sugiyama, Minoru Shigekawa, Tatsuya Sakamoto, Yoichi Sasaki, Kazuhiro Murai, Sadatsugu Sakane, Takahiro Kodama, Ryotaro Sakamori, Shogo Kobayashi, Hidetoshi Eguchi, Nobuyuki Takemura, Norihiro Kokudo, Hideki Yokoi, Masashi Mukoyama, Tomohide Tatsumi, Tetsuo Takehara   +18 more
doaj   +1 more source

Activation of Stat3 Transcription Factor by Herpesvirus Saimiri STP-A Oncoprotein [PDF]

Journal of Virology, 2004
ABSTRACT The saimiri transforming protein (STP) oncogene of Herpesvirus saimiri subgroup A strain 11 (STP-A11) is not required for viral replication but is required for lymphoid cell immortalization in culture and lymphoma induction in primates. We previously showed that STP-A11 interacts with cellular Src
Young-Hwa, Chung, Nam-hyuk, Cho, Maria Ines, Garcia, Sun-Hwa, Lee, Pinghui, Feng, Jae U, Jung   +5 more
openaire   +2 more sources

THE RELATIONSHIP OF THIOL STATUS, AND COMPONENTS OF SIGNALING PATHWAYS THAT REGULATE INFLAMMATION IN CONVALESCENTS WITH COMMUNITY-ACQUIRED PNEUMONIA

Архивъ внутренней медицины, 2018
The study discusses the relationship of thiol concentrations in intercellular fluid with the level of peripheral blood mononuclear cells (MNCs) in convalescents with community-acquired pneumonia (CAP) components MAPK/SAPK and JAK/STAT-signaling pathways,
S. S. Bondar, I. V. Terekhov, V. K. Parfenyuk, N. V. Bondar, V. S. Nikiforov   +4 more
doaj   +1 more source

Protective Effect of Niclosamide on Lipopolysaccharide-induced Sepsis in Mice by Modulating STAT3 Pathway

Korean Journal of Clinical Laboratory Science, 2023
Sepsis is a systemic inflammatory response, with manifestations in multiple organs by pathogenic infection. Currently, there are no promising therapeutic strategies.
Se Gwang JANG
doaj   +1 more source

The Transcription Factor STAT3 Is Required for T Helper 2 Cell Development [PDF]

Immunity, 2011
Signal transducer and activator of transcription (STAT) family members direct the differentiation of T helper cells, with specific STAT proteins promoting distinct effector subsets. STAT6 is required for the development of T helper 2 (Th2) cells, whereas STAT3 promotes differentiation of Th17 and follicular helper T cell subsets.
Stritesky, Gretta L., Muthukrishnan, Rajarajeswari, Sehra, Sarita, Goswami, Ritobrata, Pham, Duy, Travers, Jared, Nguyen, Evelyn T., Levy, David E., Kaplan, Mark H.   +8 more
openaire   +2 more sources

A Role for Transcription Factor STAT3 Signaling in Oncogene Smoothened-driven Carcinogenesis [PDF]

Journal of Biological Chemistry, 2012
Activation of the Hedgehog (Hh) pathway is known to drive development of basal cell carcinoma and medulloblastomas and to associate with many other types of cancer, but the exact molecular mechanisms underlying the carcinogenesis process remain elusive.
Dongsheng, Gu, Qipeng, Fan, Xiaoli, Zhang, Jingwu, Xie   +3 more
openaire   +2 more sources