Results 41 to 50 of about 196,678 (325)

Sorafenib Sensitizes Glioma Cells to the BH3 Mimetic ABT-737 by Targeting MCL1 in a STAT3-Dependent Manner

Neoplasia: An International Journal for Oncology Research, 2015
The oncogenic transcription factor signal transducer and activator of transcription 3 (STAT3) is overactivated in malignant glioma and plays a key role in promoting cell survival, thereby increasing the acquired apoptosis resistance of these tumors. Here
Irina Kiprianova, Janina Remy, Nelli Milosch, Isabelle V. Mohrenz, Volker Seifert, Achim Aigner, Donat Kögel   +6 more
doaj   +1 more source

Prediction and experimental validation of novel STAT3 target genes in human cancer cells. [PDF]

PLoS ONE, 2009
The comprehensive identification of functional transcription factor binding sites (TFBSs) is an important step in understanding complex transcriptional regulatory networks.
Young Min Oh, Jong Kyoung Kim, Yongwook Choi, Seungjin Choi, Joo-Yeon Yoo   +4 more
doaj   +1 more source

STAT3, a hub protein of cellular signaling pathways, is triggered by β-hexaclorocyclohexane [PDF]

, 2018
Background: Organochlorine pesticides (OCPs) are widely distributed in the environment and their toxicity is mostly associated with the molecular mechanisms of endocrine disruption.
Altieri, F, Carissimi, S, Chichiarelli, S, Eufemi, M, Giamogante, F, Macone, A, Paglia, G, Rubini, E   +7 more
core   +2 more sources

Signal Transducer and Activator of Transcription 3 Control of Human T and B Cell Responses

Frontiers in Immunology, 2018
Signal transducer and activator of transcription 3 (STAT3) is a transcription factor that is activated downstream of many key cytokine receptors expressed by lymphocytes.
Elissa K. Deenick, Elissa K. Deenick, Simon J. Pelham, Simon J. Pelham, Alisa Kane, Alisa Kane, Alisa Kane, Alisa Kane, Cindy S. Ma, Cindy S. Ma   +9 more
doaj   +1 more source

Targeting STAT3 Signaling Pathway in Colorectal Cancer

Biomedicines, 2021
Signal transducer and activator of transcription 3 (STAT3) is a critical transcription factor that has been firmly associated with colorectal cancer (CRC) initiation and development. STAT3 mediates key inflammatory mechanisms in colitis-associated cancer,
Antonios N. Gargalionis, Kostas A. Papavassiliou, Athanasios G. Papavassiliou   +2 more
doaj   +1 more source

A key role for leukemia inhibitory factor in C26 cancer cachexia [PDF]

, 2015
Cachexia is an exacerbating event in many types of cancer that is strongly associated with a poor prognosis. We have identified cytokine, signaling, and transcription factors that are required for cachexia in the mouse C26 colon carcinoma model of cancer.
Jackman, Robert W., Kandarian, Susan C., Seto, Danielle N.   +2 more
core   +1 more source

THE RELATIONSHIP OF THIOL STATUS, AND COMPONENTS OF SIGNALING PATHWAYS THAT REGULATE INFLAMMATION IN CONVALESCENTS WITH COMMUNITY-ACQUIRED PNEUMONIA

Архивъ внутренней медицины, 2018
The study discusses the relationship of thiol concentrations in intercellular fluid with the level of peripheral blood mononuclear cells (MNCs) in convalescents with community-acquired pneumonia (CAP) components MAPK/SAPK and JAK/STAT-signaling pathways,
S. S. Bondar, I. V. Terekhov, V. K. Parfenyuk, N. V. Bondar, V. S. Nikiforov   +4 more
doaj   +1 more source

STAT3 is Activated by CTGF-mediated Tumor-stroma Cross Talk to Promote HCC ProgressionSummary

Cellular and Molecular Gastroenterology and Hepatology, 2023
Background & Aims: Signal transducer and activator of transcription 3 (STAT3) is known as a pro-oncogenic transcription factor. Regarding liver carcinogenesis, however, it remains controversial whether activated STAT3 is pro- or anti-tumorigenic ...
Yuki Makino, Hayato Hikita, Seiya Kato, Masaya Sugiyama, Minoru Shigekawa, Tatsuya Sakamoto, Yoichi Sasaki, Kazuhiro Murai, Sadatsugu Sakane, Takahiro Kodama, Ryotaro Sakamori, Shogo Kobayashi, Hidetoshi Eguchi, Nobuyuki Takemura, Norihiro Kokudo, Hideki Yokoi, Masashi Mukoyama, Tomohide Tatsumi, Tetsuo Takehara   +18 more
doaj   +1 more source

Intermolecular disulfide bond influences unphosphorylated STAT3 dimerization and function [PDF]

, 2016
Signal transducer and activator of transcription 3 (STAT3) is a transcription factor activated by the phosphorylation of tyrosine 705 in response to many cytokines and growth factors.
Butturini, E, Canetti, D, Chiavegato, G, Cozzolino, F, Dell'Orco, D, Gotte, G, Marino, V, Mariotto, S, Monti, M, Pucci, P   +9 more
core   +1 more source

Foxm1 mediates LIF/Stat3-dependent self-renewal in mouse embryonic stem cells and is essential for the generation of induced pluripotent stem cells. [PDF]

PLoS ONE, 2014
Activation of signal transducer and activator of transcription 3 (Stat3) by leukemia inhibitory factor (LIF) is required for maintaining self-renewal and pluripotency of mouse embryonic stem cells (mESCs).
Guixiang Tan, Liang Cheng, Tuanhui Chen, Li Yu, Yongjun Tan   +4 more
doaj   +1 more source