Results 171 to 180 of about 50,546 (263)

Computational analysis of non-synonymous SNPs in the sheep MC4R gene. [PDF]

J Genet Eng Biotechnol
Hoda A, Ajçe S, Mikerezi I, Koleci X.
europepmc   +1 more source

The Natural Product Corramycin Acts as a DNA Gyrase Poison and Overcomes Fluoroquinolone Resistance in Mycobacterium tuberculosis

Advanced Science, EarlyView.
Corramycin, a myxobacterial natural product antibiotic, exhibits potent bactericidal activity against multidrug‐resistant Mycobacterium tuberculosis. The compound hijacks bacterial transporters such as BacA and OppABCD to enter the cell and inhibits DNA synthesis through a previously unrecognized mode of DNA gyrase poisoning, locking the enzyme in an ...
Franziska Fries, Jennifer Herrmann, Michael Dal Molin, Yaëlle Wormser, Timo Risch, Yunsheng Gao, Gareth Prosser, Francesca Gubellini, Ariel Mechaly, Joshua B. Wallach, Anthony Castro, Arka Banerjee, Sari Rasheed, Alexander Horn, Mathias Müsken, Michael Kurz, Lindsay Sonnenkalb, Viola Dreyer, Stefan Niemann, Sönke Andres, Dirk Schnappinger, Uli Kazmaier, Norbert Reiling, Rolf Müller, Jan Rybniker, Stéphanie Petrella   +25 more
wiley   +1 more source

Despotism promotes dyadic cooperation through enhanced interdependencies in non-human primate societies. [PDF]

Nat Commun
Bhattacharjee D, Zijlstra TW, Roth TS, Belli E, Calis S, Escriche Chova P, Cousin E, de Jong JA, de Laat EJAM, Guðjónsdóttir AR, Janmaat KRL, Jeunink EJ, Kluiver CE, Kuijer PEN, Middelburg E, Pflüger LS, Schroderus VI, van Dijk ESJ, Verspeek J, Waasdorp S, Zeeman AN, Sterck EHM, van Leeuwen EJC, Massen JJM.   +23 more
europepmc   +1 more source

Lithium Niobate Electro‐Optic Photonic Processor for Variational Quantum Eigensolver

Advanced Science, EarlyView.
An integrated lithium‐niobate‐on‐insulator ququart processor implements an electro‐optically controlled photonic variational quantum eigensolver using single photons encoded in four path modes. Bell‐basis‐emulating ququart projective measurements reduce measurement settings while achieving chemical‐accuracy‐level molecular‐energy estimation.
Jinil Lee, Ui Joon Park, Minho Choi, Hyeong‐Soon Jang, Sunghyun Moon, Hyeon Hwang, Min‐Kyo Seo, Dae‐Hwan Ahn, Sang‐Wook Han, Yong‐Su Kim, Hyounghan Kwon, Hojoong Jung   +11 more
wiley   +1 more source

Long-term cultivation shifts transcriptomic profile of HCT-116 cells. [PDF]

MicroPubl Biol
Marquardt G, Wießner-Kroh T, Rubner S, Papasotiriou I.   +3 more
europepmc   +1 more source

Stability of string vacua

Nuclear Physics B, 1986
openaire   +1 more source

In-cell bypass diodes for high-efficiency and shading-tolerant back contact silicon photovoltaic modules. [PDF]

Nat Commun
Tang H, Li Y, Lin H, Xue C, Wang G, Xu Y, Ye F, Fang L, Xu X, Gao P.   +9 more
europepmc   +1 more source

Rhoifolin Alleviates Ulcerative Colitis by Targeting NMNAT1 and Activating SIRT1‐FOXO1 Signaling to Enhance ILC3s Effector Function

Advanced Science, EarlyView.
Rhoifolin directly targets NMNAT1, thereby activating nicotinamide salvage pathway and promoting intracellular NAD+ biosynthesis. Elevated NAD+ levels enhance SIRT1 activity, leading to FOXO1 deacetylation and nuclear translocation. Nuclear FOXO1 subsequently binds to the IL‐22 promoter, upregulating IL‐22 transcription and potentiating ILC3 effector ...
Hongqiong Yang, Yishu Zhang, Sijia Feng, Xiaoqing Ma, Jiayi Feng, Junwei Wang, Jialin Gao, An Pan, Dapeng Wu, Kang Ding, Caijuan Zheng, Qi Lv, Lihong Hu   +12 more
wiley   +1 more source

CLOUD: A Scalable and Physics-Informed Foundation Model for Crystal Representation Learning. [PDF]

Nat Commun
Xu C, Zhu S, Viswanathan V.
europepmc   +1 more source

Copper‐Doped Prussian Blue Nanozymes With Hyaluronic Acid‐Mediated Targeting Alleviate Oxidative Stress and Regulate Cholesterol Handling for Atherosclerosis Therapy

Advanced Science, EarlyView.
CuPB@HA is a CD44‐associated, plaque‐targeted nanozyme that alleviates oxidative stress, inflammation, and lipid accumulation in macrophages. By reducing CD36‐dependent lipid uptake and promoting ABCA1/ABCG1‐mediated cholesterol handling, it improves macrophage function, preferentially accumulates in atherosclerotic lesions, reduces plaque burden, and ...
Jianliang Ou, Ruihua Ji, Qinglu Zang, Mingkang Wang, Lingling Zhou, Yingliang Wei, Di Yang, Yue Wu, Hongxu Zhu, Jianrong Wu, Xiaojun Cai, Wenxian Du, Junjie Cheng, An Zeng, Yuehua Li   +14 more
wiley   +1 more source