Results 151 to 160 of about 2,477,505 (293)

Reversing Temozolomide Resistance in Glioblastoma Based on Cuproptosis‐Mediated Positive Feedback Loop

open access: yesAdvanced Science, EarlyView.
To effectively reverse TMZ resistance, this work proposes a cuproptosis‐mediated positive feedback loop that integrates mitochondrial dysfunction, ATP depletion, AMPK‐p53 signaling, and glycolytic inhibition, ultimately amplifying cell death. This cuproptosis‐mediated feedback loop simultaneously disrupts multiple resistance pathways in GBM, including ...
Wenjie Feng   +9 more
wiley   +1 more source

Western String Chamber Orchestra, November 11, 1992

open access: yes, 2016
Recorded at Dalton Center Recital Hall, November 11, 1992.Western String Chamber Orchestra, Bruce Uchimura, conductor ; Tanya Treat, cello (in the 2nd work) ; Kristin van Ausdal, violin (in the 4th work) ; Jonathon Ellis, viola (in the 4th work).Sinfonia
Western String Chamber Orchestra
core   +2 more sources

AI‐Assisted Engineering of Glycyrrhizic Acid/Simvastatin Nanocrystals for Multifunctional Treatment of Bacterial Osteomyelitis

open access: yesAdvanced Science, EarlyView.
Through AI‐assisted screening from FDA‐approved API to overcome the limitations of bacterial osteomyelitis treatment, glycyrrhizic acid and simvastatin are identified as a multifunctional combination capable of self‐assembling into mechanism‐targeting nanocrystals that effectively neutralize reactive oxygen species, suppress M1 macrophage polarization,
Yu Han   +11 more
wiley   +1 more source

T-duality invariant approaches to string theory [PDF]

open access: yes, 2010
PhDThis thesis investigates the quantum properties of T-duality invariant formalisms of String Theory. We introduce and review duality invariant formalisms of String Theory including the Doubled Formalism.
Thompson, Daniel C.
core  

Human Dental Pulp Stem Cell Secretome Restores Ischemic Stroke–Impaired Motor and Cognitive Functions by Reprogramming Redox and Inflammatory Signaling

open access: yesAdvanced Science, EarlyView.
Human dental pulp stem cell secretome emerges as a cell‐free therapeutic strategy for ischemic stroke by reprogramming redox and inflammatory signaling. hDPSC secretome‐derived antioxidant and immunomodulatory factors suppress the TLR4–NOX–ROS–NF‐κB axis, reduce microglial inflammatory responses and apoptosis, and promote neurogenesis, angiogenesis ...
Kyung‐Joo Seong   +8 more
wiley   +1 more source

Review of Gastrointestinal Capsule Robots: Materials, Actuation, Diagnostics, and Therapeutics

open access: yesAdvanced Science, EarlyView.
This review examines gastrointestinal capsule robots through a systems engineering lens, covering shell materials, actuation and localization strategies, diagnostic modalities, therapeutic interventions, and commercialization status. By mapping the complete technological chain from fabrication to clinical deployment, this work identifies critical gaps ...
Zengsheng Li   +8 more
wiley   +1 more source

Western String Quartet, October 21, 1977

open access: yes, 2018
Recorded during a live performance at Oakland Recital Hall, Western Michigan University, October 21, 1977, program no. 128 of the Department of Music's 1977-1978 season.Western String Quartet (Gerald Fischbach, violin ; Barry Ross, violin ; Joseph Work ...
Western String Quartet
core  

Stochastic Entanglement of Deterministic Origami Tentacles For Robust Robotic Grasping

open access: yesAdvanced Science, EarlyView.
This study introduces an origami tentacle gripper to robustly grasp objects‐in air, underwater, and even in orbital space‐by exploiting a synergy between local, deterministic deformation programming and global, stochastic entanglements. A single origami tentacle can be designed to coil with a simple tendon pull.
Alec Boron   +4 more
wiley   +1 more source

Western String Quartet, January 13, 1977

open access: yes, 2018
Recorded during a live performance at Oakland Recital Hall, Western Michigan University, January 13, 1978, program no. 99 of the Department of Music's 1977-1978 season.Western String Quartet (Gerald Fischbach and Barry Ross, violin ; Joseph Work, viola ;
Western String Quartet
core  

CLRe: A Synergistic Dual‐Engine Framework for One‐Step Retrosynthesis Prediction

open access: yesAdvanced Science, EarlyView.
CLRe uses a contrastive difficulty score to order pretrained seq2seq fine‐tuning for retrosynthesis. Reaction embeddings define the ranking score, and a cumulative easy‐to‐hard schedule expands from the easiest subset to the full training set while earlier examples remain active.
Tianhao Su   +5 more
wiley   +1 more source

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