Results 141 to 150 of about 287,878 (297)

Analysis of Drill String Coupled Vibration and Drilling Fluid Pressure in Downhole Section

Shiyou jixie, 2021
To address the problem of nonlinear coupled vibration of the drill string in the axial, lateral and torsional direction in the downhole section of deepwater drilling, a mathematical model of nonlinear coupled vibration of the drill string in the downhole
Liu Jing, Wang Chuan, Hao Chen, Du Qingyun, Wang Tao, Zhang Cheng   +5 more
doaj  

A Testis‐Specific Aralkylamine N‐Acetyltransferase Regulates Dimorphic Sperm Function and Male Fertility in Moths

Advanced Science, EarlyView.
We identify a Lepidoptera‐conserved testis‐specific arylalkylamine N‐acetyltransferase (LTNAT) that governs male moth fertility via a novel mechanism. LTNAT loss disrupts eupyrene sperm mitochondrial derivatives and impairs apyrene sperm motility, offering a safe molecular target for innovative pesticides and genetic pest control.
Hao Sun, Peng‐Yi Huang, Zhi‐Ruo Zhang, Cong‐Fen Gao, Subba Reddy Palli, Shun‐Fan Wu   +5 more
wiley   +1 more source

Machine Learning for Green Solvents: Assessment, Selection and Substitution

Advanced Science, EarlyView.
Environmental regulations have intensified demand for green solvents, but discovery is limited by Solvent Selection Guides (SSGs) that quantify solvent sustainability. Training a machine learning model on GlaxoSmithKline SSG, a database of sustainability metrics for 10,189 solvents, GreenSolventDB is developed. Integrated with Hansen solubility metrics,
Rohan Datta, Janhavi Nistane, Abhishek Sose, Harikrishna Sahu, Rampi Ramprasad   +4 more
wiley   +1 more source

S-duality and Tensionless 5-branes in Compactified Heterotic String Theory

, 1999
We give a simple proof of the known S-duality of Heterotic String theory compactified on a T^6. Using this S-duality we calculate the tensions for a class of BPS 5-branes in Heterotic String theory on a circle.
Krogh, Morten
core   +1 more source

Mapping Genetic Regulation of Transcription to Identify Functional Variants and Genes Associated with Pancreatic Cancer Risk

Advanced Science, EarlyView.
Integration of a pancreatic eQTL map with a GWAS meta‐analysis identifies 82 putative functional variants and 15 genes. The association between rs11102484 and pancreatic cancer risk is observed in a total of 5699 cases and 8467 controls. The G allele of rs11102484 weakens ZNF263 binding and the silencer‐promoter interaction, thereby increasing ST7L ...
Xiaoyang Wang, Hui Geng, Zhengyan Yao, Yuan Jiang, Can Chen, Zequn Lu, Shuangshuang Tian, Ming Zhang, Ruiyan Liu, Chenxi Feng, Bin Li, Xiaoping Miao, Jianbo Tian, Shaokai Zhang, Ying Zhu   +14 more
wiley   +1 more source

Null Energy Condition Violation and Classical Stability in the Bianchi I Metric

, 2009
The stability of isotropic cosmological solutions in the Bianchi I model is considered. We prove that the stability of isotropic solutions in the Bianchi I metric for a positive Hubble parameter follows from their stability in the Friedmann-Robertson ...
A. A. Starobinsky, A. A. Starobinsky, A. M. Lyapunov, A. M. Lyapunov, D. J. Mulryne, D. M. Grobman, G. F. R. Ellis, I. Ya. Aref’eva, I. G. Petrovsky, I. Ya. Aref’eva, I. Ya. Aref’eva, L. V. Joukovskaya, L. S. Pontryagin, N. V. Bulatov, P. Hartman, P. Hartman, S. Yu. Vernov, S. W. Hawking, S. Yu. Vernov   +18 more
core   +1 more source

DMAP1 Deficiency Suppresses Lung Cancer Progression by Destabilizing Replication Fork and Activating IFN Signaling‐Mediated Anti‐tumor Immunity

Advanced Science, EarlyView.
Lung cancer remains the leading cause of cancer‐related death. We investigated the role of the epigenetic regulator DMAP1 in NSCLC and found that its loss induces replication stress and DNA damage. This in turn activates type I IFN signaling via the cGAS–STING pathway and transcriptional ISG de‐repression, enhancing anti‐tumor immune responses ...
Kan Huang, Xi Dai, Shuaihu Li, Yingxue Chen, Yaxin Yu, Lin Wang, Kun Liu, Shuhan Lyu, Chongyang Li, Yihua Sun, Fei Li   +10 more
wiley   +1 more source

Stability of string configurations dual to quarkonium states in AdS/CFT

, 2007
We extend our earlier work, regarding the perturbative stability of string configurations used for computing the interaction potential of heavy quarks within the gauge/gravity correspondence, to cover a more general class of gravity duals.
Aharony, Ahn, Ahn, Arfken, Argyres, Avramis, Avramis, Avramis, Avramis, Bakas, Bakas, Berenstein, Bliss, Brandhuber, Brandhuber, Brandhuber, Cai, Callan, Callen, Caratheodory, Chernicoff, Courant, Cvetic, Cvetic, Cvetic, Cáceres, Durand, Freedman, Friess, Frolov, Frolov, Gross, Gubser, Gubser, Harmark, Hernández, Hernández, Ince, Kinar, Kinar, Klebanov, Klebanov, Klebanov, Konstadinos Sfetsos, Konstadinos Siampos, Kraus, Landau, Leigh, Liu, Liu, Lunin, Maldacena, Maldacena, Maldacena, Natsuume, Peeters, Rashkov, Rey, Rey, Russo, Sfetsos, Sonnenschein, Spyros D. Avramis, Whittaker, Witten, Witten   +65 more
core   +1 more source

Distinct Immunomodulatory Strategies Guide Mesenchymal Stromal/Stem Cell‐Mediated Bone Regeneration

Advanced Science, EarlyView.
Bone regeneration by mesenchymal stem cells is strongly influenced by immune signals. This study shows that priming stem cells with regulatory immune cells or an inflammation‐resolving lipid molecule enhances bone formation through distinct immune pathways.
Salwa Suliman, Carla Alvarez Rivas, Aashish Srivastava, Nora Marek, Kamal Mustafa, Alpdogan Kantarci   +5 more
wiley   +1 more source

Decoding IGLL5 Mutation‐Mediated BCR Signaling: A Novel Mechanism of CD8+ T Cell Exhaustion and Ocular MALT Lymphoma Progression

Advanced Science, EarlyView.
OAML harbors recurrent IGLL5 mutations that reinforce CD79A/CD79B‐associated BCR signaling. Mechanistic analysis of the S47G and A54G variants reveals induction of CXCL10/CXCL11, enhanced CD8+ T‐cell recruitment, and exhaustion‐associated dysfunction, supporting an immune‐tolerant niche.
Andi Zhao, Haoyu Wei, Chenyu Zhou, Xinping Sun, Shuyan Da, Haiyu Liu, Zijin Wang, Hui Zhu, Shiya Shen, Qing Shao, Qi Gong, Hu Liu, Xuejuan Chen   +12 more
wiley   +1 more source