Factors Influencing Sulforaphane Content in Broccoli Sprouts and Subsequent Sulforaphane Extraction [PDF]
Foods, 2021 Broccoli sprouts contain 10–100 times higher levels of sulforaphane than mature plants, something that has been well known since 1997. Sulforaphane has a whole range of unique biological properties, and it is especially an inducer of phase 2 detoxication
Jan Tříska +10 more
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Glucoraphanin conversion into sulforaphane and related compounds by gut microbiota [PDF]
Frontiers in PhysiologyGlucosinolate glucoraphanin, common in cruciferous vegetables, is a biologically stable precursor of isothiocyanates, such as sulforaphane and erucin, potent activators of Nrf2 signaling coordinating an adaptive response to oxidative stress. Sulforaphane
Tetiana R. Dmytriv +5 more
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Sulforaphane regulates AngII-induced podocyte oxidative stress injury through the Nrf2-Keap1/ho-1/ROS pathway [PDF]
Renal FailureObjective This study aimed to investigate the therapeutic effects of sulforaphane and the role of the Nrf2-Keap1/HO-1/ROS pathway in AngII-induced oxidative stress in podocyte injury.Methods Mouse mpc5 podocytes were divided into four groups: control ...
Wen Lu
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Sulforaphane inhibits the Th2 immune response in ovalbumin-induced asthma [PDF]
BMB Reports, 2012 Sulforaphane (1-isothiocyanato-4-(methylsulfinyl)-butane), belongingto a family of natural compounds that are abundant in broccoli,has received significant therapeutic interest in recent years.However, the molecular basis of its effects remains to ...
Jun Ho Park +11 more
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LncRNA ENSSSCG00000035331 Alleviates Hippocampal Neuronal Ferroptosis and Brain Injury Following Porcine Cardiopulmonary Resuscitation by Regulating the miR-let7a/GPX4 Axis. [PDF]
CNS Neurosci TherABSTRACT Background Following successful cardiopulmonary resuscitation, those survivors of cardiac arrest (CA) often suffer from severe brain injury, and the latter can result in significant mortality and morbidity. Emerging evidence implicates that ferroptosis is involved in the pathogenesis of post‐resuscitation brain injury, and its regulatory ...
Zhang M +9 more
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Effect of sulforaphane on testicular ischemia-reperfusion injury induced by testicular torsion-detorsion in rats [PDF]
Scientific ReportsTesticular ischemia-reperfusion induces enhanced concentration of reactive oxygen species. The increased reactive oxygen species harm cellular lipids, nucleic acids, proteins, and carbohydrates, and ultimately cause testicular injury.
Si-Ming Wei, Yu-Min Huang
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Research advances in the protective effect of sulforaphane against kidney injury and related mechanisms [PDF]
BIO Web of Conferences, 2022 Kidney injury and related diseases have become quite common in recent years, and have attracted more attention. Sulforaphane, a kind of isothiocyanate, is widely distributed in cruciferous plants and it is a common antioxidant. Specifically, sulforaphane
Chang Ruoxi
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Medicinal Research Reviews, Volume 43, Issue 1, Page 237-287, January 2023., 2023 Abstract The transcription factor nuclear factor erythroid 2‐related factor 2 (NRF2) is considered the master regulator of the phase II antioxidant response. It controls a plethora of cytoprotective genes related to oxidative stress, inflammation, and protein homeostasis, among other processes.
Enrique Crisman +6 more
wiley +1 more source
Physiological Reports, 2021 Objective Excessive exercise increases the production of reactive oxygen species in skeletal muscles. Sulforaphane activates nuclear factor erythroid 2‐related factor 2 (Nrf2) and induces a protective effect against oxidative stress.
Shoichi Komine +6 more
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Sulforaphane modulates TGFβ2-induced conjunctival fibroblasts activation and fibrosis by inhibiting PI3K/Akt signaling [PDF]
International Journal of Ophthalmology, 2020 AIM: To examine the effects of sulforaphane on fibrotic changes of transforming growth factor (TGFβ2) induced human conjunctival fibroblast (HConFs).
Han-Ruo Liu, Zi-Yao Xia, Ning-Li Wang
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