Results 1 to 10 of about 29,600 (252)

Novel Gram-Scale Production of Enantiopure R-Sulforaphane from Tuscan Black Kale Seeds

Molecules, 2014
Dietary R-sulforaphane is a highly potent inducer of the Keap1/Nrf2/ARE pathway. Furthermore, sulforaphane is currently being used in clinical trials to assess its effects against different tumour processes. This study reports an efficient preparation of
Gina Rosalinda De Nicola, Patrick Rollin, Emanuela Mazzon, Renato Iori   +3 more
doaj   +1 more source

The pharmacological regulation of cellular mitophagy [PDF]

, 2017
Small molecules are pharmacological tools of considerable value for dissecting complex biological processes and identifying potential therapeutic interventions.
A Brunet, A Cassidy-Stone, A Hoshino, A Hoshino, A Jain, A Kazlauskaite, A Khaminets, A Managò, A Orvedahl, A Sargsyan, A Schiavi, AE Alekseev, AT Dinkova-Kostova, AY Amerik, B Arun, B Bingol, B Maro, BJ Gurd, BM Kenwood, BS Padman, C Jo, C Jo, C Kondapalli, C Zhang, CA da Costa, CN Cunningham, CT Chu, D Liu, D Narendra, D Narendra, DA East, DA East, DP Narendra, EA Liberman, EF Fang, EH Kim, EH Kim, F Gao, F Ivanes, G Ashrafi, G Bellot, G Chen, G Wells, Geoff Wells, GFG Allen, GL McLelland, H Jia, H Sandoval, H Wei, H Zhang, HC Bertrand, HT Kang, I Kim, I Novak, IH Lee, J Gatliff, J Gatliff, J H Zhu, J Li, J Viotti, J Yun, J-H Zhu, JR Jangamreddy, K Grenier, K-S Park, KKK Chung, KM Holmström, L Liu, M Frank, M Fu, M Lazarou, M Mauro-Lizcano, M Mogi, M Redmann, Michelangelo Campanella, MV Tsiper, NA Khan, ND Georgakopoulos, Nikolaos D Georgakopoulos, NT Hertz, NV Kirienko, P Bai, Q Shen, R Huang, R Rupprecht, RD Sentelle, RJ Youle, RK Dagda, S Givvimani, S Kume, S Melser, S Rikka, SA Hasson, SJ Park, SM Jin, SY Jang, TM Durcan, W Duan, W Yue, X Qi, Y Kageyama, Y Wang, YP Yang, YQ Liu   +103 more
core   +4 more sources

Growth temperature influences postharvest glucosinolate concentrations and hydrolysis product formation in first and second cuts of rocket salad [PDF]

, 2020
Rocket salad species (Diplotaxis tenuifolia and Eruca sativa; also known as E. vesicaria) are known for their high concentrations of health-related isothiocyanates, which are derived from secondary metabolites called glucosinolates.
Bell, Luke, Jasper, Jake, Wagstaff, Carol   +2 more
core   +1 more source

Sulforaphane Activates a lysosome-dependent transcriptional program to mitigate oxidative stress

Autophagy, 2020
Oxidative stress underlies a number of pathological conditions, including cancer, neurodegeneration, and aging. Antioxidant-rich foods help maintain cellular redox homeostasis and mitigate oxidative stress, but the underlying mechanisms are not clear ...
Dan Li, R. Shao, Na Wang, N. Zhou, Kaili Du, Jiahui Shi, Yihan Wang, Zhuangzhuang Zhao, Xing Ye, Xiaoli Zhang, Haoxing Xu   +10 more
semanticscholar   +1 more source

Sulforaphane regulates AngII-induced podocyte oxidative stress injury through the Nrf2-Keap1/ho-1/ROS pathway

Renal Failure
Objective This study aimed to investigate the therapeutic effects of sulforaphane and the role of the Nrf2-Keap1/HO-1/ROS pathway in AngII-induced oxidative stress in podocyte injury.Methods Mouse mpc5 podocytes were divided into four groups: control ...
Wen Lu
doaj   +1 more source

p63 is a key regulator of iRHOM2 signalling in the keratinocyte stress response. [PDF]

, 2018
Hyperproliferative keratinocytes induced by trauma, hyperkeratosis and/or inflammation display molecular signatures similar to those of palmoplantar epidermis.
Arcidiacono, P, Blaydon, DC, Brooke, MA, Chikh, A, Delaney, PJ, Kelsell, DP, Ng, K-E, Tinker, A, Webb, CM, Zhou, H   +9 more
core   +2 more sources

Efficacy of Sulforaphane in Neurodegenerative Diseases

International Journal of Molecular Sciences, 2020
Sulforaphane (SFN) is a phytocompound belonging to the isothiocyanate family. Although it was also found in seeds and mature plants, SFN is mainly present in sprouts of many cruciferous vegetables, including cabbage, broccoli, cauliflower, and Brussels ...
Giovanni Schepici, P. Bramanti, E. Mazzon   +2 more
semanticscholar   +1 more source

Transcriptome reveals the gene expression patterns of sulforaphane metabolism in broccoli florets.

PLoS ONE, 2019
Sulforaphane is a new and effective anti-cancer component that is abundant in broccoli. In the past few years, the patterns of variability in glucosinolate content and its regulation in A. thaliana have been described in detail. However, the diversity of
Zhansheng Li, Yumei Liu, Lingyun Li, Zhiyuan Fang, Limei Yang, Mu Zhuang, Yangyong Zhang, Honghao Lv   +7 more
doaj   +1 more source

Friend and foe: factors influencing the movement of the bacterium Helicobacter pylori along the parasitism-mutualism continuum. [PDF]

, 2014
Understanding the transition of bacterial species from commensal to pathogen, or vice versa, is a key application of evolutionary theory to preventative medicine.
Koskella, Britt, Lin, Derek
core   +1 more source

Sulforaphane as a preventive agent in Oral Cancer- A Systematic Review

Oral Oncology Reports
Background: Cancer is one of the leading causes of death worldwide. Of these, oral cancer is the sixth most common malignancy. Several phytochemicals are emerging these days in prevention of oral cancer. Sulforaphane present in broccoli is one such agent
M. Parasakthi, Kavitha Sanjeev
doaj   +1 more source