Results 191 to 200 of about 22,428 (226)

Sulforaphane protects against cisplatin-induced nephrotoxicity

Toxicology Letters, 2010
Cisplatin (cis-diamminedichloroplatinum II, CDDP) is a chemotherapeutic agent that induces nephrotoxicity associated with oxidative/nitrosative stress. Sulforaphane (SFN) is an isothiocyanate produced by the enzymatic action of myrosinase on glucorophanin, a glucosinolate contained in cruciferous vegetables. SFN is able to induce cytoprotective enzymes
Carlos Enrique, Guerrero-Beltrán, Mariel, Calderón-Oliver, Edilia, Tapia, Omar N, Medina-Campos, Dolores Javier, Sánchez-González, Claudia María, Martínez-Martínez, Karla Mariana, Ortiz-Vega, Martha, Franco, José, Pedraza-Chaverri   +8 more
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Sulforaphane protects against acetaminophen-induced hepatotoxicity

Food and Chemical Toxicology, 2015
Oxidative stress is closely associated with acetaminophen (APAP)-induced toxicity. Heme oxygenase-1 (HO-1), an antioxidant defense enzyme, has been shown to protect against oxidant-induced tissue injury. This study investigated whether sulforaphane (SFN), as a HO-1 inducer, plays a protective role against APAP hepatotoxicity in vitro and in vivo ...
Jung-Ran, Noh, Yong-Hoon, Kim, Jung Hwan, Hwang, Dong-Hee, Choi, Kyoung-Shim, Kim, Won-Keun, Oh, Chul-Ho, Lee   +6 more
openaire   +2 more sources

Antileukemic Activity of Sulforaphane

2016
The biological complexity of cancer offers numerous targets for antineoplastic therapies. Diet is a common source of biologically active compounds. Many studies demonstrated an inverse relation between the consumption of vegetables and the risk of cancer.
CATANZARO, ELENA, FIMOGNARI, CARMELA
openaire   +1 more source

Thermal Degradation of Sulforaphane in Aqueous Solution

Journal of Agricultural and Food Chemistry, 1999
Sulforaphane, a cancer chemopreventive agent identified from broccoli, was degraded in an aqueous solution at 50 and 100 degrees C. The reaction mixtures were extracted with methylene chloride and analyzed by gas chromatography (GC) and gas chromatography/mass spectrometry (GC/MS).
Rosen, RT, Jin, Y, Wang, M, Ho, CT
openaire   +4 more sources

Preparative HPLC Method for the Purification of Sulforaphane and Sulforaphane Nitrile from Brassica oleracea

Journal of Agricultural and Food Chemistry, 2001
An extraction and preparative HPLC method has been devised to simultaneously purify sulforaphane and sulforaphane nitrile from the seed of Brassica oleracea var. italica cv. Brigadier. The seed was defatted with hexane, dried, and hydrolyzed in deionized water (1:9) for 8 h. The hydrolyzed seed meal was salted and extracted with methylene chloride. The
N V, Matusheski, M A, Wallig, J A, Juvik, B P, Klein, M M, Kushad, E H, Jeffery   +5 more
openaire   +2 more sources

Theoretical investigation of sulforaphane molecule

Journal of Molecular Structure: THEOCHEM, 2005
The structural and electronic properties of the broccoli sulforaphane molecule have been investigated theoretically by performing semi-empirical molecular orbital (PM3) and density functional theory calculations. The geometry of the molecule has been optimized by PM3 method and the electronic properties and the vibrational spectra of the molecule have ...
Erkoc, S, Erkoc, F
openaire   +2 more sources

Evaporative Light-Scattering Analysis of Sulforaphane in Broccoli Samples:  Quality of Broccoli Products Regarding Sulforaphane Contents

Journal of Agricultural and Food Chemistry, 2006
Broccoli sulforaphane has received attention as a possible anticarcinogen. Sulforaphane analysis is difficult due to the lack of a chromophore for spectrometric detection. Hence, we developed a method for determining sulforaphane by using high-performance liquid chromatography (HPLC) coupled with an evaporative light-scattering detector (ELSD ...
Kiyotaka, Nakagawa, Toshiko, Umeda, Ohki, Higuchi, Tsuyoshi, Tsuzuki, Toshihide, Suzuki, Teruo, Miyazawa   +5 more
openaire   +2 more sources

Dual Roles of Sulforaphane in Cancer Treatment

Anti-Cancer Agents in Medicinal Chemistry, 2012
Sulforaphane (SFN), one of naturally occurring isothiocyanates (ITCs), has huge cancer chemopreventive potential. It modulates cell death, cell cycle, angiogenesis, susceptibility to carcinogens, invasion and metastasis and possesses antioxidant activities.
Tongzhen, Xu, Dongmei, Ren, Xuefei, Sun, Guotao, Yang   +3 more
openaire   +2 more sources

Sulforaphane and mitochondria

2021
Katarzyna Zyla, Scott M. Plafker
openaire   +1 more source

Sulforaphane Activates a lysosome-dependent transcriptional program to mitigate oxidative stress

Autophagy, 2021
Dan Li, Rong Shao, Kaili Du
exaly