Results 51 to 60 of about 2,697,657 (391)
Plasticity of Dendritic Spines. Not Only for Cognitive Processes [PDF]
, 2017 Excitatory synaptic transmission is associated with the input of “new” information at synaptic junctions established by dendritic spines. The role that each type of spine plays in the transmission of the synaptic impulses is different. Indeed, there is a
González-Burgos, Ignacio +4 more
core +2 more sources
Phenomenological modeling of diverse and heterogeneous synaptic dynamics at natural density [PDF]
, 2022 This chapter sheds light on the synaptic organization of the brain from the perspective of computational neuroscience. It provides an introductory overview on how to account for empirical data in mathematical models, implement such models in software, and perform simulations reflecting experiments.
arxiv +1 more source
Mitochondrial Dysfunction and Synaptic Transmission Failure in Alzheimer's Disease.
Journal of Alzheimer's Disease, 2017 Alzheimer's disease (AD) is a chronic neurodegenerative disorder, in which multiple risk factors converge. Despite the complexity of the etiology of the disease, synaptic failure is the pathological basis of cognitive impairment, the cardinal sign of AD.
Lan Guo, Jing Tian, Heng Du
semanticscholar +1 more source
Tadr is an axonal histidine transporter required for visual neurotransmission in Drosophila
eLife, 2022 Neurotransmitters are generated by de novo synthesis and are essential for sustained, high-frequency synaptic transmission. Histamine, a monoamine neurotransmitter, is synthesized through decarboxylation of histidine by histidine decarboxylase (Hdc ...
Yongchao Han, Lei Peng, Tao Wang
doaj +1 more source
Metabolic constraints on synaptic learning and memory [PDF]
Journal of Neurophysiology 122: 1473-1490 (2019), 2019 Dendritic spines, the carriers of long-term memory, occupy a small fraction of cortical space, and yet they are the major consumers of brain metabolic energy. What fraction of this energy goes for synaptic plasticity, correlated with learning and memory?
arxiv +1 more source
Journal of Neuroscience Research, 2017 Astrocytes, the major glial cell type in the central nervous system (CNS), are critical for brain function and have been implicated in various disorders of the central nervous system.
Ciaran Murphy-Royal +3 more
semanticscholar +1 more source
mGluR-dependent synaptic plasticity in drug-seeking.
Frontiers in Pharmacology, 2012 A primary feature of drug addiction is the compulsive use despite negative consequences. A general consensus is emerging on the capacity of addictive substances to co-opt synaptic transmission and synaptic plasticity in brain circuits which are involved ...
Camilla eBellone +3 more
doaj +1 more source
A Chemical Master Equation Model for Synaptic Molecular Communication [PDF]
, 2021 In synaptic molecular communication, the activation of postsynaptic receptors by neurotransmitters (NTs) is governed by a stochastic reaction-diffusion process and, hence, inherently random. It is currently not fully understood how this randomness impacts downstream signaling in the target cell and, ultimately, neural computation and learning.
arxiv +1 more source
Oxygen/Glucose deprivation induces a reduction in synaptic AMPA receptors on hippocampal CA3 neurons mediated by mGluR1 and adenosine A3 receptors [PDF]
, 2011 Hippocampal CA1 pyramidal neurons are highly sensitive to ischemic damage, whereas neighboring CA3 pyramidal neurons are less susceptible. It is proposed that switching of AMPA receptor (AMPAR) subunits on CA1 neurons during an in vitro model of ischemia,
Cimarosti, Helena +5 more
core +1 more source
AMPA receptor anchoring at CA1 synapses is determined by N-terminal domain and TARP γ8 interactions. [PDF]
, 2021 AMPA receptor (AMPAR) abundance and positioning at excitatory synapses regulates the strength of transmission. Changes in AMPAR localisation can enact synaptic plasticity, allowing long-term information storage, and is therefore tightly controlled ...
Greger, Ingo H +3 more
core +3 more sources