Results 51 to 60 of about 164,559 (291)

Presynaptically silent synapses are modulated by the density of surrounding astrocytes

Journal of Pharmacological Sciences, 2020
Astrocytes, comprising the primary glial-cell type, are involved in the formation and maturation of synapses, and thus contribute to sustainable synaptic transmission between neurons.
Kohei Oyabu, Kotomi Takeda, Hiroyuki Kawano, Kaori Kubota, Takuya Watanabe, N. Charles Harata, Shutaro Katsurabayashi, Katsunori Iwasaki   +7 more
doaj   +1 more source

Gestational dexamethasone exposure impacts hippocampal excitatory synaptic transmission and learning and memory function with transgenerational effects

Acta Pharmaceutica Sinica B, 2023
The formation of learning and memory is regulated by synaptic plasticity in hippocampal neurons. Here we explored how gestational exposure to dexamethasone, a synthetic glucocorticoid commonly used in clinical practice, has lasting effects on offspring's
Mingcui Luo, Yiwen Yi, Songqiang Huang, Shiyun Dai, Lulu Xie, Kexin Liu, Shuai Zhang, Tao Jiang, Tingting Wang, Baozhen Yao, Hui Wang, Dan Xu   +11 more
doaj   +1 more source

Rab11 as a modulator of synaptic transmission [PDF]

Communicative & Integrative Biology, 2013
Many neurodegenerative disorders are characterized by synaptic dysfunction preceding general neuronal loss and subsequent cognitive or behavioral anomalies. Much recent research has been aimed at understanding the early underlying processes leading to dysfunction at the synapse, as this knowledge would likely inform interventions that could potentially
Giorgini, Flaviano, Steinert, Joern R.
openaire   +3 more sources

A Novel Approach to Implementing Artificial Thalamic Neurons with Ferroelectric Transistors

Advanced Functional Materials, EarlyView.
Artificial neurons created using CMOS technology often require a large number of transistors and capacitors. This study introduces an artificial thalamic neuron that employs only five CMOS compatible ferroelectric transistors. The manufactured thalamic neuron demonstrates leaky integrate‐and‐fire‐or‐burst (LIFB) functionalities, featuring self ...
Andreas Grenmyr, Jiayuan Zhang, Jingxuan Sun, Kenta Moto, Stefan Wiefels, Seong‐Ryong Koh, Detlev Grützmacher, Qing‐Tai Zhao   +7 more
wiley   +1 more source

Efficient Coding and Energy Efficiency Are Promoted by Balanced Excitatory and Inhibitory Synaptic Currents in Neuronal Network

Frontiers in Cellular Neuroscience, 2018
Selective pressure may drive neural systems to process as much information as possible with the lowest energy cost. Recent experiment evidence revealed that the ratio between synaptic excitation and inhibition (E/I) in local cortex is generally ...
Lianchun Yu, Lianchun Yu, Zhou Shen, Chen Wang, Yuguo Yu   +4 more
doaj   +1 more source

All‐in‐One Analog AI Hardware: On‐Chip Training and Inference with Conductive‐Metal‐Oxide/HfOx ReRAM Devices

Advanced Functional Materials, EarlyView.
An all‐in‐one analog AI accelerator is presented, enabling on‐chip training, weight retention, and long‐term inference acceleration. It leverages a BEOL‐integrated CMO/HfOx ReRAM array with low‐voltage operation (<1.5 V), multi‐bit capability over 32 states, low programming noise (10 nS), and near‐ideal weight transfer.
Donato Francesco Falcone, Victoria Clerico, Wooseok Choi, Tommaso Stecconi, Folkert Horst, Laura Bégon‐Lours, Matteo Galetta, Antonio La Porta, Nikhil Garg, Fabien Alibart, Bert Jan Offrein, Valeria Bragaglia   +11 more
wiley   +1 more source

Transducer Materials Mediated Deep Brain Stimulation in Neurological Disorders

Advanced Functional Materials, EarlyView.
This review discusses advanced transducer materials for improving deep brain stimulation (DBS) in neurological disorders. These materials respond to light, ultrasound, or magnetic fields, enabling precise, less invasive neuromodulation. Their stimulus‐responsive properties enhance neural control and adaptive therapy, paving the way for next‐generation ...
Di Zhao, Zhengyang Cao, Guangjun Zhong, Limin Shi, Junxia Xie, Jianhua Hao   +5 more
wiley   +1 more source

Engineering Topographical Cues to Enhance Neural Regeneration in Spinal Cord Injury: Overcoming Challenges and Advancing Therapies

Advanced Functional Materials, EarlyView.
Spinal cord injury (SCI) poses significant challenges for regeneration due to a series of secondary injury mechanisms. How to use biomaterial approach to target the failed regeneration after SCI remains a critical challenge. This review systematically evaluates current strategies to optimize biomaterial topographies for neurite outgrowth, axonal ...
Wei Xu, Fenghui Wang, Joshua Stein, Siqiao Wang, Pengfei Jiang, Letao Yang, Liming Cheng, Ki‐Bum Lee   +7 more
wiley   +1 more source

Maternal Immune Activation Affects Hippocampal Excitatory and Inhibitory Synaptic Transmission in Offspring From an Early Developmental Period to Adulthood

Frontiers in Cellular Neuroscience, 2020
One of the risk factors for schizophrenia is maternal infection. We have previously shown that Polyriboinosinic-polyribocytidylic acid (poly I:C) induced maternal immune activation in mice caused histological changes in the hippocampal CA1 area of ...
Keiju Nakagawa, Hiroki Yoshino, Yoichi Ogawa, Kazuhiko Yamamuro, Sohei Kimoto, Yoshinobu Noriyama, Manabu Makinodan, Masayuki Yamashita, Yasuhiko Saito, Toshifumi Kishimoto   +9 more
doaj   +1 more source

GLIA modulates synaptic transmission

Brain Research Reviews, 2010
The classical view of glial cells as simple supportive cells for neurons is being replaced by a new vision in which glial cells are active elements involved in the physiology of the nervous system. This new vision is based on the fact that astrocytes, a subtype of glial cells in the CNS, are stimulated by synaptically released neurotransmitters, which ...
Alfonso Araque, Gertrudis Perea
openaire   +3 more sources