Results 111 to 120 of about 44,470 (243)

Persisting Region‐Specific Microglia Activation and Synaptic Imbalance During Remission in a DSS‐Induced Colitis Model

open access: yesGlia, Volume 74, Issue 11, November 2026.
Relapsing colitis region‐specific microglial states beyond remission. Cortical microglia remain pro‐inflammatory and synapse‐disruptive, while hippocampal microglia shift toward a reparative program that maintains neuronal circuit stability. ABSTRACT Ulcerative colitis (UC) patients experience cycles of active gut inflammation and remission, with ...
Lorena Morton   +6 more
wiley   +1 more source

Pathogenic Variants in HEPACAM Alter Protein Localization and Interactome in Astrocytes of the Developing Mouse Cortex

open access: yesGlia, Volume 74, Issue 11, November 2026.
Pathogenic variants alter hepaCAM protein distribution. Astrocyte‐specific hepaCAM TurboID reveals KCNQ2 as a new interaction partner. Pathogenic variants alter hepaCAM association with key transmembrane proteins. ABSTRACT Megalencephalic leukoencephalopathy with subcortical cysts (MLC) is a rare leukodystrophy characterized by early‐onset macrocephaly,
Robert W. Lewis   +10 more
wiley   +1 more source

How L-lactate mediates energetics and exercise-enhanced neuroplasticity in Parkinson’s disease

open access: yesRedox Experimental Medicine
In the past decade, there have been several major paradigm shifts impacting our understanding and treatment of neurological disorders, such as Parkinson’s disease (PD). The concept of neuroplasticity in the context of a neurological disorder and aging is
G Gupta   +4 more
doaj   +1 more source

Cell Surface Markers Identify Astrocyte Subpopulations in the Adult Hippocampus With a Heterogeneous Response to Aging

open access: yesGlia, Volume 74, Issue 11, November 2026.
ATP1B2 and GLAST identify two astrocyte subpopulations in the hippocampus with distinct molecular signatures. Transcriptomic shifts during aging differ between both subpopulations. Aged ATP1B2+ astrocytes rewire their metabolism while double‐positive aged astrocytes display a reduced synaptogenic capability.
Lucía Casares‐Crespo   +6 more
wiley   +1 more source

Adeno-associated virus-mediated inhibition of ROCK2 promotes synaptogenesis and neurogenesis in rats after ischemic stroke

open access: yesNeural Regeneration Research
Neurite outgrowth and synaptogenesis are critical steps for functional recovery following ischemic stroke. Damaged axons of the central nervous system in adult mammals exhibit limited regenerative capacity, resulting in enduring neurological deficits ...
Liuliu Shi   +5 more
doaj   +1 more source

Optimizing Genetically-Driven Synaptogenesis

open access: yes
In this paper we introduce SynaptoGen, a novel framework that aims to bridge the gap between genetic manipulations and neuronal network behavior by simulating synaptogenesis and guiding the development of neuronal networks capable of solving ...
Ferrante, Matteo   +2 more
core  

Ten‐Eleven Translocation Enzymes Control the Rate and Mode of Retinal Progenitor Cell Division in the Developing Retina

open access: yesThe FASEB Journal, Volume 40, Issue 19, 15 October 2026.
Early RPCs divide predominantly symmetrically and exhibit a high proliferation rate, resulting in rapid retinal growth. Late RPCs divide predominantly asymmetrically and exhibit a low proliferation rate. Our results suggest that TET‐deficient RPCs divide predominantly asymmetrically but exhibit a high proliferation rate.
Galina Dvoriantchikova   +3 more
wiley   +1 more source

SPEECH IN RHYTHM OR WHY INTENSIVE AND INTERVAL THERAPY IN SPEECH THERAPY WORKS

open access: yesListy klinicke logopedie
Speech, movement, proper ontogenetic development of the individual, cognition, emotions, ability to learn, memory and the list could go on. All of these are directly dependent on balance, which is based on the rhythm realised at an optimal pace with ...
Veronika Včelíková, Lea Šafránková
doaj   +1 more source

Temporal Appearance of the Presynaptic Cytomatrix Protein Bassoon during Synaptogenesis

open access: yes, 2000
Bassoon is a 420-kDa presynaptic cytomatrix protein potentially involved in the structural organization of neurotransmitter release sites. In this study, we have investigated a possible role for Bassoon in synaptogenesis and in defining synaptic vesicle ...
Gundelfinger, Eckart D   +9 more
core   +1 more source

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