Results 111 to 120 of about 63,572 (265)

Analysis of quantification methods used for cell viability, cell morphology, and synaptic formation in modeling HIV associated dementia in primary neuronal cultures. [PDF]

, 2009
Change is inevitable, changes in neuronal function occur in physiologic and pathologic processes. The ability to reliably analyze and quantify those changes in neuronal morphology and function has been an important part of technical developments in ...
Saunders, John James
core  

Density-dependence of functional development in spiking cortical networks grown in vitro

, 2008
During development, the mammalian brain differentiates into specialized regions with distinct functional abilities. While many factors contribute to functional specialization, we explore the effect of neuronal density on the development of neuronal ...
A Tang, B Anderson, Cara L. Santa Maria, DA Wagenaar, E Maeda, E Schneidman, F Rieke, G Bi, G Shahaf, G Spitsyna, H Markram, JH Kim, JM Beggs, JP Pfister, K Nakanishi, L Paninski, LMA Bettencourt, LMA Bettencourt, Luìs M. A. Bettencourt, M Abeles, M Diesmann, MA Corner, Marko A. Rodriguez, MI Ham, Michael I. Ham, O Feinerman, RM Herndon, Ryan A. Bennett, S Marom, TM Cover, Vadas Gintautas, Y Jimbo   +31 more
core   +1 more source

Psychedelics, entactogens and psychoplastogens for depression and related disorders

British Journal of Pharmacology, EarlyView.
Currently, the most actively investigated rapidly acting antidepressants, anxiolytics and/or anti PTSD agents, include psychedelics e.g. psilocybin, LSD, N,N‐dimethyltryptamine, ayahuasca; non‐hallucinogenic entactogens, e.g. MDMA; psychoplastogens which rapidly promote neuroplasticity, e.g.
Daniel Hoyer
wiley   +1 more source

Early Gabapentin Treatment during the Latency Period Increases Convulsive Threshold, Reduces Microglial Activation and Macrophage Infiltration in the Lithium-Pilocarpine Model of Epilepsy

Pharmaceuticals, 2017
The lithium-pilocarpine model of epilepsy reproduces several features of temporal lobe epilepsy in humans, including the chronological timeline of an initial latency period followed by the development of spontaneous seizures. Epilepsy therapies in humans
Alicia Rossi, Veronica Murta, Jerónimo Auzmendi, Alberto Javier Ramos   +3 more
doaj   +1 more source

Next‐Generation Strategies for Neural Repair and Regeneration: Neural Organoid Transplantation in the CNS

Cell Proliferation, EarlyView.
Neurological disorders are hard to treat. Stem cell‐derived neural organoids enable research, and their transplantation aids CNS therapy, with this article reviewing relevant advances, challenges and prospects. ABSTRACT Neurological disorders are often devastating and notoriously difficult to repair, creating an urgent need for novel research models ...
Yutong Wang, Jinrui Li, Xingjia Mao, Wanyu Wang, Yansong Li, Xuefei Hu, Jinjie Zhong, Fengdong Zhao, Linlin Wang   +8 more
wiley   +1 more source

An update on the landscape of collagen bioactive fragments

The FEBS Journal, EarlyView.
The remodeling of the extracellular matrix releases collagen bioactive fragments, which exert molecular functions and regulate numerous biological processes via several signaling pathways. Here, we summarize the latest findings describing the roles of major bioactive fragments from collagens I, IV, VI, and XVIII in various physiological and ...
Sylvie Ricard‐Blum, Julie Fradette
wiley   +1 more source

Extracellular Vesicles Derived from FGF2-Primed Astrocytes Against Mitochondrial and Synaptic Toxicities in Parkinson’s Disease

International Journal of Nanomedicine
Xiaomin Wen,1,2,* Wanjun Cao,2,* Hui Ding,2 Andi Chen,2 Zhichuan Sun,2 Yazhou Wang,2 Ye Xi,2 Shengxi Wu2 1College of Life Sciences, Northwest University, Xi’an, Shaanxi, 710069, People’s Republic of China; 2Department of Neurobiology, School of ...
Wen X, Cao W, Ding H, Chen A, Sun Z, Wang Y, Xi Y, Wu S   +7 more
doaj  

Steroidogenic compensation and lipid deficiency with enhanced NAD+ salvage in small‐for‐gestational‐age placenta

The FEBS Journal, EarlyView.
Fetal growth restriction is associated with placental metabolic adaptations. In small‐for‐gestational‐age placenta (SGA), cholesterol receptors and steroidogenic enzymes are upregulated, enhancing steroidogenesis. NAD salvage pathway is also increased to support NADP+/NADPH requirements.
Serena Xodo, Lorenza Driul, Vanessa Tolotto, Eros Di Giorgio, Luigi E. Xodo   +4 more
wiley   +1 more source

Regulation of CNS and motor axon guidance in Drosophila by the receptor tyrosine phosphatase DPTP52F [PDF]

, 2001
Receptor-linked protein tyrosine phosphatases (RPTPs) regulate axon guidance and synaptogenesis in Drosophila embryos and larvae. We describe DPTP52F, the sixth RPTP to be discovered in Drosophila.
Knirr, Matthias, Schindelholz, Benno, Warrior, Rahul, Zinn, Kai   +3 more
core  

Contrasting population genomic structuring of northern pike (Esox lucius L.) in fresh‐ and brackish water environments: Implications for management and conservation

Journal of Fish Biology, EarlyView.
Abstract Understanding the factors that shape population genetic structure is crucial for advancing evolutionary studies and developing effective management and conservation strategies. The northern pike (Esox lucius L.) is a top teleost predator that inhabits fresh and brackish water environments in the northern hemisphere.
Alfonso Diaz‐Suarez, María‐Eugenia López, Göran Sundblad, Anti Vasemägi   +3 more
wiley   +1 more source