Results 111 to 120 of about 44,470 (243)
Relapsing colitis region‐specific microglial states beyond remission. Cortical microglia remain pro‐inflammatory and synapse‐disruptive, while hippocampal microglia shift toward a reparative program that maintains neuronal circuit stability. ABSTRACT Ulcerative colitis (UC) patients experience cycles of active gut inflammation and remission, with ...
Lorena Morton +6 more
wiley +1 more source
Integrative regulation of cerebral blood flow in response to exercise and environmental extremes
Experimental Physiology, EarlyView.
Shigehiko Ogoh, Damian M. Bailey
wiley +1 more source
Pathogenic variants alter hepaCAM protein distribution. Astrocyte‐specific hepaCAM TurboID reveals KCNQ2 as a new interaction partner. Pathogenic variants alter hepaCAM association with key transmembrane proteins. ABSTRACT Megalencephalic leukoencephalopathy with subcortical cysts (MLC) is a rare leukodystrophy characterized by early‐onset macrocephaly,
Robert W. Lewis +10 more
wiley +1 more source
How L-lactate mediates energetics and exercise-enhanced neuroplasticity in Parkinson’s disease
In the past decade, there have been several major paradigm shifts impacting our understanding and treatment of neurological disorders, such as Parkinson’s disease (PD). The concept of neuroplasticity in the context of a neurological disorder and aging is
G Gupta +4 more
doaj +1 more source
ATP1B2 and GLAST identify two astrocyte subpopulations in the hippocampus with distinct molecular signatures. Transcriptomic shifts during aging differ between both subpopulations. Aged ATP1B2+ astrocytes rewire their metabolism while double‐positive aged astrocytes display a reduced synaptogenic capability.
Lucía Casares‐Crespo +6 more
wiley +1 more source
Neurite outgrowth and synaptogenesis are critical steps for functional recovery following ischemic stroke. Damaged axons of the central nervous system in adult mammals exhibit limited regenerative capacity, resulting in enduring neurological deficits ...
Liuliu Shi +5 more
doaj +1 more source
Optimizing Genetically-Driven Synaptogenesis
In this paper we introduce SynaptoGen, a novel framework that aims to bridge the gap between genetic manipulations and neuronal network behavior by simulating synaptogenesis and guiding the development of neuronal networks capable of solving ...
Ferrante, Matteo +2 more
core
Early RPCs divide predominantly symmetrically and exhibit a high proliferation rate, resulting in rapid retinal growth. Late RPCs divide predominantly asymmetrically and exhibit a low proliferation rate. Our results suggest that TET‐deficient RPCs divide predominantly asymmetrically but exhibit a high proliferation rate.
Galina Dvoriantchikova +3 more
wiley +1 more source
SPEECH IN RHYTHM OR WHY INTENSIVE AND INTERVAL THERAPY IN SPEECH THERAPY WORKS
Speech, movement, proper ontogenetic development of the individual, cognition, emotions, ability to learn, memory and the list could go on. All of these are directly dependent on balance, which is based on the rhythm realised at an optimal pace with ...
Veronika Včelíková, Lea Šafránková
doaj +1 more source
Temporal Appearance of the Presynaptic Cytomatrix Protein Bassoon during Synaptogenesis
Bassoon is a 420-kDa presynaptic cytomatrix protein potentially involved in the structural organization of neurotransmitter release sites. In this study, we have investigated a possible role for Bassoon in synaptogenesis and in defining synaptic vesicle ...
Gundelfinger, Eckart D +9 more
core +1 more source

