Results 131 to 140 of about 44,470 (243)

A Systematic Review and Meta‐Analysis of Biological Sex Differences in Sleep Spindles and Slow Wave Activity in Adults With and Without Insomnia

Journal of Sleep Research, Volume 35, Issue 5, October 2026.
ABSTRACT Mounting evidence shows sex‐based differences in sleep experiences and outcomes, including the prevalence of insomnia disorder. However, the impact of biological sex on brain oscillations during sleep remains poorly understood, especially in the context of insomnia disorder. This is a notable gap, given that neurophysiological aspects of sleep
Nyissa A. Walsh, Emma‐Maria Phillips, Arsenio Páez, Nathan E. Cross, Thien Thanh Dang‐Vu, Aurore A. Perrault   +5 more
wiley   +1 more source

Structure‐Guided Optimization of PDE9A Inhibitors Tackling Neuroinflammation: A Combined Computational and In Vitro Study

ChemMedChem, Volume 21, Issue 17, 14 September 2026.
Computational studies allowed the identification of a PDE9A inhibitor. A novel HPLC‐based assay was developed and optimized to measure enzyme function to assess PDE9A inhibition. Furthermore, in vitro tests supported the activity of the compound against neuroinflammation. Oxidative stress and inflammation are key players in central nervous system (CNS)
Giovanni Ribaudo, Elisa Landucci, Margrate Anyanwu, Costanza Mazzantini, Matteo Giannangeli, Stefano Rosa, Francesca Mainolfi, Maura Calvani, Maurizio Memo, Domenico E. Pellegrini‐Giampietro, Alessandra Gianoncelli   +10 more
wiley   +1 more source

Neurotrophin & synaptogenesis

, 2020
Synaptogenesis is encoded by multiple genes that program the assembly of neural networks in the immature brain during development and later in life, in the experienced brain that must respond to changes of the external world and of proprioception. Processing of neural network activity cannot solely rely on the activity of established synapses as their ...
Jeanneteau, Freddy, Arango-Lievano, Margarita, Chao, Moses   +2 more
openaire   +1 more source

Synaptogenesis between identified neurons

, 1995
Serotonergic Retzius (R) neurons of the leech Hirudo medicinalis in culture reform inhibitory synapses with pressure sensitive (P) neurons while selectively reducing an extrasynaptic, depolarizing response to serotonin (5-HT) in the P neuron.
Ching, Shim
core  

Correction: Neurotrophic factor-α1/carboxypeptidase E regulates critical protein networks to rescue neurodegeneration, defective synaptogenesis and impaired autophagy in Alzheimer's disease mice. [PDF]

Transl Neurodegener
Xiao L, Sharma P, Yang X, Abebe D, Loh YP.   +4 more
europepmc   +1 more source

Neurotrophin and synaptogenesis [PDF]

, 2020
Freddy Jeanneteau, Margarita Arango-Lievano, Moses V. Chao   +2 more
openaire   +1 more source

A Synaptogenesis-Associated Histomorphologic Signature from H&E Whole-Slide Images Predicts Glioma Prognosis and Identifies <i>EFNB2</i>-Positive Malignant Cells as a Candidate Neuro-Glioma Communication Hub. [PDF]

Int J Mol Sci
Wu X, Liu D, Geng H, Zhang B, Diao H, Zhou Y, Song G, Cheng Y, Liang J.   +8 more
europepmc   +1 more source

Selective Synaptogenesis in the Development of Cell-Type-Specific Connectivity in the Cerebral Cortex

The cerebral cortex contains many neuronal cell types, which differ in morphology, electrophysiology, and functional roles in cortical circuits. These cell types exhibit selective synaptic connectivity, which may be regulated by axonal and dendritic ...
Gutman-Wei, Alan Yinong
core   +1 more source

Mechanistic Differences in Adult-Onset and Juvenile-Onset Huntington's Disease and the Potential Role of Neurodevelopment. [PDF]

Cureus
Anjur Thupil V, Satchidanand N.
europepmc   +1 more source

When neuroligin-2 sticks around, astrocytes take shape. [PDF]

J Cell Biol
Ray S, Singhvi A.
europepmc   +1 more source