Results 51 to 60 of about 13,916,688 (296)
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Analisis Kemampuan Technological Pedagogical Content Knowledge Mahasiswa Calon Guru Kimia
JIPI (Jurnal IPA dan Pembelajaran IPA), 2022 The effectiveness of a learning is determined by the combination of various dimensions of knowledge with technology carried out by teachers. This study aims to analyse the TPACKs’ skills of chemistry education students of FKIP Untan who will become the ...
Maria Ulfah*, Erlina Erlina
doaj +1 more source
De uitdaging van grootschalige stelsel voor ketencommunicatie : over de betekenis van het vakgebied 'Keteninformatisering in de rechtstaat' [PDF]
, 2011 Wij leiden vooral op in kleinschalig rationeel denken, of het nu wiskunde, informatiekunde, geneeskunde of rechtswetenschappen betreft. Grootschalige stelsels plaatsen ons daarom in de praktijk voor moeilijke uitdagingen, omdat onze -op rationele ...
Sub Content & Knowledge Engineering begr +3 more
core +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Research on the Model of Technological Pedagogical Content Knowledge of Teachers (TPACK)
Zhishi guanli luntan, 2019 [Purpose/significance] TPACK framework doesn’t describe the level of knowledge, and the generation and transformation process of knowledge. This paper constructed a TCP teacher knowledge system model to describe the TPACK structure of teachers more ...
Zhan Rui
doaj +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
DEVELOPING TECHNOLOGICAL PEDAGOGICAL CONTENT KNOWLEDGE OF ENGLISH LANGUAGE TEACHERS
Journal on Efficiency and Responsibility in Education and Science, 2013 Integration of information and communication technology into other than Information Technology subjects taught at schools of all levels in the Czech Republic has become of great importance.
CARBOVÁ, Anna, BETÁKOVÁ, Lucie
doaj +1 more source
European Journal of English Language TeachingA qualitative study was conducted in a Vietnamese city to investigate the EFL teachers’ perspectives on CK, TCK, and PCK. Qualitative data revealed that integrating Technological Pedagogical Content Knowledge (TPACK) into English teaching practices is considered time-consuming, impeded by factors such as time constraints and students' cognitive ...
openaire +1 more source