Results 1 to 10 of about 6,088 (246)

Intratumoral tertiary lymphoid structure (TLS) maturation is influenced by draining lymph nodes of lung cancer [PDF]

Journal for ImmunoTherapy of Cancer, 2023
Background Tertiary lymphoid structure (TLS) is an organized infiltration of immune cells, showing features of germinal center (GC) commonly seen in secondary lymphoid organs. However, its relationship with tumor-draining lymph nodes (TDLNs) has not been
Jun Liu, Xiuyu Cai, Wenhua Liang, Jianxing He, Yi Lu, Feng Li, Miao He, Qihua He, Hongshen Deng, Ran Zhong, Haoxin Peng, Xiangrong Wu, Zisheng Chen, Shen Lao, Caichen Li, Jianfu Li   +15 more
doaj   +5 more sources

Identification of a tertiary lymphoid structure (TLS)-related signature for ovarian cancer prognosis suggests a potential role of STAT5A in TLS maturation. [PDF]

Genes Dis
Yang J, Zhang Y, Cheng S, Xu Y, Wu M, Gu S, Ma M, Zhao Y, Wang C, Wang Y.   +9 more
europepmc   +4 more sources

Tertiary lymphoid structures as local perpetuators of organ-specific immune injury: implication for lupus nephritis [PDF]

Frontiers in Immunology, 2023
In response to inflammatory stimuli in conditions such as autoimmune disorders, infections and cancers, immune cells organize in nonlymphoid tissues, which resemble secondary lymphoid organs.
Meiying Wang, Meiying Wang, Meiying Wang, Snehin Rajkumar, Yupeng Lai, Xingjiao Liu, Jing He, Jing He, Tatsuya Ishikawa, Dhiraj Nallapothula, Ram Raj Singh, Ram Raj Singh, Ram Raj Singh, Ram Raj Singh   +13 more
doaj   +3 more sources

Tertiary lymphoid structures in cancer: maturation and induction [PDF]

Frontiers in Immunology
Tertiary lymphoid structure (TLS) is an ectopic lymphocyte aggregate formed in peripheral non-lymphoid tissues, including inflamed or cancerous tissue.
Yulu Chen, Yulu Chen, Yulu Chen, Yuhao Wu, Yuhao Wu, Yuhao Wu, Guorong Yan, Guorong Yan, Guorong Yan, Guolong Zhang, Guolong Zhang, Guolong Zhang   +11 more
doaj   +3 more sources

Multi-omics profiling and experimental verification of tertiary lymphoid structure-related genes: molecular subgroups, immune infiltration, and prognostic implications in lung adenocarcinoma [PDF]

Frontiers in Immunology
Lung adenocarcinoma (LUAD), characterized by a low 5-year survival rate, is the most common and aggressive type of lung cancer. Recent studies have shown that tertiary lymphoid structures (TLS), which resemble lymphoid structures, are closely linked to ...
Sixuan Wu, Sixuan Wu, Junfan Pan, Qihong Pan, Lijun Zeng, Renji Liang, Yuehua Li   +6 more
doaj   +3 more sources

A Grading System of Intratumoral Tertiary Lymphoid Structure for Combined Hepatocellular-Cholangiocarcinoma: A Multicenter Pathological Study. [PDF]

J Hepatocell Carcinoma
Purpose Tertiary lymphoid structure (TLS) has been well-established across multiple tumor types for predicting efficacy of immunotherapy and prognostic evaluation. However, its role in combined hepatocellular-cholangiocarcinoma (cHCC-CCA) remains unclear.
Wang H, Qian YW, Zhao Y, Sheng X, Xia CY, Chen HZ, Cong WM, He MX, Dong H.   +8 more
europepmc   +2 more sources

Tertiary lymphoid structure can be a potential therapeutic target for head and neck squamous cell carcinoma (Review). [PDF]

Mol Clin Oncol
Tertiary lymphoid structure (TLS) is a kind of ectopic lymphoid tissues that form in chronic inflammation or tumor microenvironment (TME) and is structurally similar to secondary lymphoid organs such as lymph nodes, containing B cell follicles, T cell ...
Shen J, Yang X.
europepmc   +2 more sources

Effect of tumor draining lymph nodes in the formation and maturation of tertiary lymphoid structure in patients with lung adenocarcinoma. [PDF]

BMC Cancer
Tertiary lymphoid structures (TLSs), ectopic lymphoid aggregates composed of immune cells, are associated with favorable clinical outcomes and increased efficacy of anti-tumor immunotherapies.
Wen J, Yun W, Yin X, Meng X.
europepmc   +2 more sources

The impact of metabolic reprogramming on tertiary lymphoid structure formation: enhancing cancer immunotherapy

BMC Medicine
Background Cancer immunotherapy has achieved unprecedented success in the field of cancer therapy. However, its potential is constrained by a low therapeutic response rate.
Meng-Jie Zhang, Yan Wen, Zhi-Jun Sun
doaj   +2 more sources

Tertiary lymphoid structures in renal cell carcinoma: from heterogeneity dissection to translational precision immunotherapy [PDF]

Frontiers in Immunology
Renal cell carcinoma (RCC), characterized by its distinctive hypoxic and immunosuppressive tumor microenvironment (TME), demonstrates suboptimal responses to current immunotherapeutic interventions.
Zhexian Li, Zhexian Li, Sensen Ruan, Yang Yu, Hao Xiang, Wenjie Mi, Wenjie Mi   +6 more
doaj   +2 more sources