Results 101 to 110 of about 6,088 (246)

Tumor‐infiltrating B cells participate in shaping the immunosuppressive microenvironment in solid tumors

International Journal of Cancer, Volume 158, Issue 5, Page 1156-1165, 1 March 2026.
Abstract Tumor‐infiltrating B cells (TIBs) exhibit dual roles in the tumor microenvironment (TME) of solid tumors. While they can enhance anti‐tumor immunity through antibody production and immune activation, certain subsets—such as regulatory B cells (Bregs) and immunosuppressive plasma cells—contribute to immune evasion by secreting inhibitory ...
Zhitong Li, Ziyang Shen, Yuxiang Sun, Pengcheng Zhu, Tongyan Liu, Rong Yin   +5 more
wiley   +1 more source

Translational and Oncologic Significance of Tertiary Lymphoid Structures in Pancreatic Adenocarcinoma [PDF]

Pancreatic adenocarcinoma (PDAC) is an aggressive tumor with poor survival and limited treatment options. PDAC resistance to immunotherapeutic strategies is multifactorial, but partially owed to an immunosuppressive tumor immune microenvironment (TiME ...
Azar, Joseph, Camp, E Ramsay, Gao, Zachary, Kang, Sung Wook, Lee, Hyun-Sung, Makawita, Shalini, Marginean, Celia, Rubinstein, Mark P, Williams-Perez, Sophia, Zhu, Huili   +9 more
core   +2 more sources

Epstein‐Barr Virus Infection at Single‐Cell Resolution

Journal of Medical Virology, Volume 98, Issue 2, February 2026.
ABSTRACT Epstein‐Barr virus (EBV) infection has been studied at single‐cell resolution for six decades and counting. Such investigations can reveal virus‐host interactions and their dependence on viral strain, cellular niche, infection program, immune response regulation, and time.
Elliott D. SoRelle
wiley   +1 more source

Tumor Immunotherapy and Microbiome: From Bench‐to‐Bedside Applications

MedComm, Volume 7, Issue 2, February 2026.
The microbiome is related to the efficacy of immunotherapy and can be utilized to predict the efficacy and adverse reactions of immunotherapy. Microbiome‐targeted intervention strategies can improve the efficacy of ICI, but necessitating more comprehensive exploration.
Anqi Lin, Minying Xiong, Aimin Jiang, Li Chen, Lihaoyun Huang, Kailai Li, Hank Z. H. Wong, Jian Zhang, Zaoqu Liu, Quan Cheng, Bufu Tang, Pengpeng Zhang, Peng Luo   +12 more
wiley   +1 more source

Peripheral Nerves in Cancer: Regulatory Roles and Therapeutic Strategies

MedComm, Volume 7, Issue 2, February 2026.
The interaction between cancer cells and peripheral nerves: (1) tumor cells could induce the growth of new neural axons and constructing a neural fiber network within the tumor tissue through secreting nerve growth factors; (2) nerve‐derived bioactive molecules can induce perineural invasion of tumor and regulate the malignant phenotype of tumor, such ...
Yan Fu, Zhi‐Shan Ge, Qing‐Yue Cao, Zi‐Han Li, An Zhang, Hai‐Dong Zhu, Gao‐Jun Teng   +6 more
wiley   +1 more source

Current status and prospects of tertiary lymphoid structure heterogeneity in predicting response to neoadjuvant therapy and characterizing immune microenvironment in triple-negative breast cancer [PDF]

Zhongguo aizheng zazhi
Triple-negative breast cancer (TNBC) is a highly aggressive and prognostically unfavorable subtype. Tertiary lymphoid structure (TLS) within the tumor microenvironment, comprising dendritic cells, B cells, T cells, and other immune cells, modulate the ...
WANG Qing, YU Yushuai, WANG Chenxi, JIANG Zirong, LI Jialu, TANG Shicong, SONG Chuangui
doaj   +1 more source

A novel tertiary lymphoid structure-associated signature accurately predicts patient prognosis and facilitates the selection of personalized treatment strategies for HNSCC

Frontiers in Immunology
Background Head and neck squamous cell carcinoma (HNSCC) is the most common type of head and neck cancer and is characterized by its aggressive nature and variable prognosis and response to immunotherapy.
Jinhao Zhang, Lu Zeng, Guobin Song, Gaoge Peng, Zhezheng Chen, Yamin Yuan, Taowu Chen, Tao Zhong, Shixi Chen, Zhengzhou Luo, Jingang Xiao, Lin Liu   +11 more
semanticscholar   +1 more source

Tumor Microenvironments in Malignant Ovarian Germ Cell Tumors: MHC Class I Loss and T‐Cell Exhaustion in Dysgerminoma

Cancer Science, Volume 117, Issue 2, Page 566-575, February 2026.
Malignant ovarian germ cell tumor subtypes exhibit distinct tumor microenvironments. Dysgerminomas harbor abundant nonexhausted T cells, with progenitor exhausted T cells present in 60% of PD‐1–positive cases. However, MHC class I expression is lost across all analyzed subtypes, suggesting that restoring class I expression in dysgerminomas may enhance ...
Miya Nakashima, Takeshi Iwasaki, Yoshihiro Katayama, Masatoshi Shimo, Ken Takigawa, Naomi Shimada, Michiko Matsushita, Satoshi Kuwamoto, Shinya Sato, Masato Toya, Kohta Miyawaki, Koichi Akashi, Kiyoko Kato, Yoshinao Oda   +13 more
wiley   +1 more source

Development of a tertiary lymphoid structure-based prognostic model for breast cancer: integrating single-cell sequencing and machine learning to enhance patient outcomes

Frontiers in Immunology
Background Breast cancer, a highly prevalent global cancer, poses significant challenges, especially in advanced stages. Prognostic models are crucial to enhance patient outcomes.
Xiaonan Zhang, Li Li, Xiaoyu Shi, Yunxia Zhao, Zhaogen Cai, Ni Ni, Di Yang, Zixin Meng, Xu Gao, Li Huang, Tao Wang   +10 more
semanticscholar   +1 more source

Prognostic and clinicopathological significance of tertiary lymphoid structure in non-small cell lung cancer: a systematic review and meta-analysis

BMC Cancer
Background Non-small cell lung cancer (NSCLC) is the primary reason for cancer-related deaths globally. Tertiary lymphoid structure (TLS) is an organized collection of immune cells acquired in non-physiological, non-lymphoid tissues.
Luyuan Ma, Rongyang Li, Xiaomeng Liu, Wenhao Yu, Zhanpeng Tang, Yi Shen, Hui Tian   +6 more
doaj   +1 more source