Results 11 to 20 of about 6,088 (246)

Prognostic and clinicopathological significance of tertiary lymphoid structure in esophageal squamous cell carcinoma: a systematic review and meta-analysis review. [PDF]

BMC Cancer
Tertiary lymphoid structures (TLS), ectopic immune cell aggregates in non-lymphoid tissues, have emerged as potential predictors of esophageal squamous cell carcinoma (ESCC) outcomes.
Yu CT, Gao Y, Liu RY, Ding YA, Wang LW.
europepmc   +2 more sources

CCL20 secreted by KRT15^high tumor Cells promotes tertiary lymphoid structure formation and enhances anti-PD-1 therapy response in HPV⁺HNSCC. [PDF]

Cell Death Dis
Tertiary lymphoid structures (TLS) are associated with an improved response to Immune checkpoint therapy (ICT) in head and neck squamous cell carcinoma (HNSCC). Human papillomavirus (HPV) infection constitutes a high-risk factor for HNSCC carcinogenesis.
Zhang S, Liu H, Li X, Jiang Y, Tang L, Liu T, Li R, Liu Z, Wei M, Sun J, Hahan Z, Ma H, Wei L.   +12 more
europepmc   +2 more sources

Tertiary Lymphoid Structures Across Organs: Context, Composition, and Clinical Levers. [PDF]

Immunol Rev
: Tertiary lymphoid structures (TLSs) arise in non-lymphoid tissues in response to persistent antigen stimulation and chronic inflammation. Spanning organs from lung and liver to meninges, skin, and beyond, TLSs range from loose aggregates of immune ...
Guillaume SM, Beccaria CG, Iannacone M, Linterman MA.   +3 more
europepmc   +3 more sources

Tertiary lymphoid structure drives allograft rejection via IFN-γ-JAK-STAT-dependent atypical memory B cell differentiation. [PDF]

Front Immunol
Background Tertiary lymphoid structure (TLS) is a neogenized, ectopic lymphoid aggregate found in infected, autoimmune and tumour tissues with an activated adaptive immune response.
Ma L, Gong S, Fang J, Feng M, Zhan Z, Xia Q.   +5 more
europepmc   +2 more sources

Intratumoral bacterial load and tertiary lymphoid structure density in hepatocellular carcinoma: association and prognostic significance. [PDF]

Front Immunol
Background The tertiary lymphoid structures (TLS) within the immune microenvironment of hepatocellular carcinoma (HCC) have been shown to significantly influence patient prognosis.
Qu S, Jia W, Liu X, Yao Q, Chen C, Zhao Z, Nie Y, Chang F, Yang Z, Peng C, Wang Y, Song W.   +11 more
europepmc   +2 more sources

Podoplanin expressing macrophages and their involvement in tertiary lymphoid structures in mouse models of Sjögren’s disease [PDF]

Frontiers in Immunology
Tertiary lymphoid structures (TLSs) are formed in tissues targeted by chronic inflammation processes, such as infection and autoimmunity. In Sjögren’s disease, the organization of immune cells into TLS is an important part of disease progression.
Aud-Malin Karlsson Hovd, Saba Nayar, Charlotte G. Smith, Premasany Kanapathippillai, Valentina Iannizzotto, Francesca Barone, Kristin Andreassen Fenton, Hege Lynum Pedersen   +7 more
doaj   +4 more sources

Turning Tertiary Lymphoid Structures (TLS) into Hot Spots: Values of TLS in Gastrointestinal Tumors

Cancers, 2023
Tertiary lymphoid structures (TLSs) are ectopic lymphocyte aggregation structures found in the tumor microenvironment (TME). Emerging evidence shows that TLSs are significantly correlated with the progression of gastrointestinal tumors, patients’ prognosis, and the efficacy of adjuvant therapy. Besides, there are still some immunosuppressive factors in
Daming Cai, Heng Yu, Xingzhou Wang, Yonghuan Mao, Mengjie Liang, Xiaofeng Lu, Xiaofei Shen, Wenxian Guan   +7 more
openaire   +2 more sources

Tertiary lymphoid structures critical for prognosis in endometrial cancer patients [PDF]

, 2022
B-cells play a key role in cancer suppression, particularly when aggregated in tertiary lymphoid structures (TLS). Here, we investigate the role of B-cells and TLS in endometrial cancer (EC).
, Bosse, Tjalling, Church, David N, Creutzberg, Carien L, de Boer, Stephanie M, de Bruyn, Marco, Horeweg, Nanda, Jürgenliemk-Schulz, Ina M, Koelzer, Viktor H, Krog, Ricki T, Leary, Alexandra, Loiero, Dominik, Léon-Castillo, Alicia, MacKay, Helen, Mileshkin, Linda R, Nijman, Hans W, Nout, Remi A, Powell, Melanie E, Singh, Naveena, Smit, Vincent T H B M, Vermij, Lisa, Workel, Hagma H   +21 more
core   +5 more sources

Tertiary lymphoid structures (TLS) identification and density assessment on H&E-stained digital slides of lung cancer

PLOS ONE, 2021
Tertiary lymphoid structures (TLS) are ectopic aggregates of lymphoid cells in inflamed, infected, or tumoral tissues that are easily recognized on an H&E histology slide as discrete entities, distinct from lymphocytes. TLS are associated with improved cancer prognosis but there is no standardised method available to quantify their presence ...
Panagiotis Barmpoutis, Matthew Di Capite, Hamzeh Kayhanian, William Waddingham, Daniel C. Alexander, Marnix Jansen, Francois Ng Kee Kwong   +6 more
openaire   +5 more sources

Deciphering the maturation of tertiary lymphoid structures in cancer and inflammatory diseases of the digestive tract using imaging mass cytometry

Frontiers in Immunology, 2023
Persistent inflammation can promote the development of tertiary lymphoid structures (TLS) within tissues resembling secondary lymphoid organs (SLO) such as lymph nodes (LN).
Marion Le Rochais, Patrice Hémon, Danivanh Ben-guigui, Soizic Garaud, Christelle Le Dantec, Jacques-Olivier Pers, Jacques-Olivier Pers, Divi Cornec, Divi Cornec, Arnaud Uguen, Arnaud Uguen   +10 more
doaj   +1 more source